DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS5 and Itga8

DIOPT Version :9

Sequence 1:	NP_611808.2	Gene:	ItgaPS5 / 37732	FlyBaseID:	FBgn0034880	Length:	1018	Species:	Drosophila melanogaster
Sequence 2:	NP_001167443.1	Gene:	Itga8 / 364786	RGDID:	621634	Length:	1062	Species:	Rattus norvegicus

Alignment Length:	1080	Identity:	281/1080 - (26%)
Similarity:	453/1080 - (41%)	Gaps:	200/1080 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 SYFGYSLVI-----RPTSIFVGAPRAQSTLESQGSINETGAVYRCPL---ASGSCSHYVLNDKLN 101
            |||||||..     |..|:.||||:|.:   ||..|.|.||||.||.   .|..|.....:...|
  Rat    54 SYFGYSLDFYIPDARTASVLVGAPKANT---SQPDIVEGGAVYYCPWPAERSAQCKQIPFDTTNN 115

  Fly   102 KQF--------------QWLGGSMDGGTKDTDKLLVCAPRFFVPKNKNYGQMR--------GICY 144
            ::.              ||.|.::   .....|::.|||.:      ::..::        |.||
  Rat   116 RKIRVNGTKEPIEFKSNQWFGATV---RAHKGKVVACAPLY------HWRTLKPNPAKDPVGTCY 171

  Fly   145 WVRDTVADTPPLSDVRTISLIPSQAEEHFMLELGLSAHVTDDNSGFLIGAPGVRSWKGSVLVHRG 209
            ......:.....|..|..::.|   |.....:.|.|.... .|...::|.||...|:|.|:....
  Rat   172 VAIQNFSAYAEHSPCRNSNVDP---EGQGYCQAGFSLDFY-KNGDLIVGGPGSFYWQGQVITVSV 232

  Fly   210 EDLAAQGSY--------AVKMLD----SWDWVKNHFTYVGYALSSGYFSSNNRTSLLYVTTAPSS 262
            .|:.|..|:        |.|..|    |:|     .:|:||::::|.|:.::...|  |...|..
  Rat   233 ADIIANYSFKDILRKLAAEKQTDVAPASYD-----DSYLGYSVAAGEFTGDSLQEL--VAGIPRG 290

  Fly   263 VLNTGKAYIFDVVGEIVRKLHVFHGEQLGEYFGYSVVAEDLNGDGLTDVVVSAPL----NALGDS 323
            ..|.|  |:..:....:..:..|.|||:..||||:||..|:|.||:.|::|.|||    ....:.
  Rat   291 AQNFG--YVSIINSTDMTFIQNFTGEQMASYFGYTVVVSDVNNDGMDDILVGAPLFMEREFESNP 353

  Fly   324 YDVGAIYVFINKGLFKFEKKIIRLPLSSGARFGSSLSKVGDINHDGYNDLAVGAPFAG---NGAV 385
            .:||.:|:::......|:...:.....:..|||||::.:||:|.|||||:|:|.||||   .|.|
  Rat   354 REVGQVYLYLQVSALLFQDPQVLTGTETFGRFGSSVAHLGDLNQDGYNDIAIGVPFAGKDQRGKV 418

  Fly   386 FIFLGSEHGLRDEPSQRLDAPSREPGPYGAHM----FGQGLSRGSDIDGNGFNDLAIGAPGAEAV 446
            .|:.|:..||..:|||.|.      |.:|:..    ||..|...:|||.|.:.||.:||.|...|
  Rat   419 LIYNGNARGLHSKPSQVLQ------GIWGSQTIPSGFGFSLRGDADIDKNDYPDLLVGAFGEGKV 477

  Fly   447 YLYRAYPVVKIHATVRSESRAIRPEQETI------TVTACYRLET-TSKARQ--------MQQQE 496
            .:|||.|||.:.|.:......|..|.:|.      |..||:.|.. .|.|.|        |.:.:
  Rat   478 AVYRARPVVTVDAQLLLHPMIINLENKTCQIPEFPTPVACFSLRVCASIAGQSISNTVALMAEVQ 542

  Fly   497 LTFRMTIDELLQRVSFAPMRTNEVSF----QAQAGLSGSCRNFSVGVHYTGGI---FTPIDLELH 554
            |.| :.....::|..|.....:.:.|    :.|..|  .|::|.|.:......   .:||::.|:
  Rat   543 LDF-LKQKGAIKRTLFLHNHQSHLIFPFVMRQQKSL--HCQDFMVYLRDETEFRDKLSPINVSLN 604

  Fly   555 YELAKKIPHSHEAFCESCAVVDPLEPKY----ATGTLSFMTGCAA-HVCVSDLQLSSKDVNSSFI 614
            |.|       .::..|....|.|:...|    .|.....:..|.. ::||.||:||::......|
  Rat   605 YSL-------DDSTFEDGLEVKPILNHYRENVVTEQAHILVDCGEDNLCVPDLRLSARPDKQEII 662

  Fly   615 FGSLEVLSFSYEITNSGEPAYVAQFNVTSSARLPFAKVPGN--------CRVRHE----VMLCDL 667
            .|....|.......|.||.||.|:..|.......:..:..|        |..:.|    :::|||
  Rat   663 IGDENHLMLIINARNEGEGAYEAELFVMIPEEADYVGIERNNKGLRLLSCEYKMENVTRMVVCDL 727

  Fly   668 NGGRALARGDSESLTIIFDVTQL--SGQSLTIEAAVSSAGMDQNPKDNTMSTTISLREYAEIDAS 730
              |..:..|.:.||.:.|.|.:|  :..|:..:..:.|:..| ||..|.:|..|::...|:::..
  Rat   728 --GNPMVTGTNFSLGLRFAVPRLEKTNMSINFDLQIRSSNKD-NPDSNFVSVQINVTAVAQVEIR 789

  Fly   731 GGPIDGHIAL-------KEYPYSAE-----VNNSYEFKSHGPSIIDELTVYVDVPIAYTVTGSAG 783
            |......|.|       .|.|:..|     |.:.||..:.|||.|.:..:.|..|.      ||.
  Rat   790 GVSHPPQIVLPIHNWEPAEEPHKEEEVGPLVEHIYELHNIGPSTISDSILEVGWPF------SAR 848

  Fly   784 IKSIFNISSLQMQATHGSELVPIKLYDQTNTLAKEYPLEDSSRRANRKRRELQQDQYAIMPDVNI 848
            .:.:..:..||       .|.|::.  |||   .|...:|....|:   .|...:..|.:.:..|
  Rat   849 EEFLLYVFHLQ-------TLGPLQC--QTN---PEINPQDIKPAAS---PEDTPELSAFLRNATI 898

  Fly   849 SDILTKENLPA------NRTLVLDCLRGNWTICVRSQMRV-QLKPEQPIDLRISFKVDLNDFVN- 905
            ..::.|.::|.      :...:|:|...:   |::....| :|...:...|::..::..:.|:.
  Rat   899 PHLVRKRDVPVVQPHRQSPAKILNCTNID---CLQISCAVGRLGGGESAVLKVRSRLWAHTFLQR 960

  Fly   906 -----TFDYLVIFTNVEM-FKEGDST----SIALKRNL---KPNVIFNYSETPLPIWYIILSLIA 957
                 ....||.|...:: :||..:.    |.|:|.::   .|||.|:     :|:|.|||:::.
  Rat   961 KNDPYALASLVSFEVKKIPYKEQPAKLPAGSTAIKTSVIWATPNVSFS-----IPLWVIILAILL 1020

  Fly   958 GHLLLGAMTYILYKLRFFKRGKKEELKRLLEEHRSETKEP 997
            |.|:|..:|..|:|..||.|.:..:.:....|..:..|.|
  Rat  1021 GLLVLAILTLALWKCGFFDRARPPQDEMTDREQLTSDKTP 1060

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	VCBS	302..375	CDD:338792	26/76 (34%)
		Int_alpha	351..403	CDD:214549	28/54 (52%)
		Int_alpha	417..463	CDD:214549	20/49 (41%)
		Integrin_alpha2	451..836	CDD:337057	103/437 (24%)
Itga8	NP_001167443.1	Int_alpha	53..111	CDD:214549	26/59 (44%)
		Int_alpha	316..>364	CDD:214549	18/47 (38%)
		Int_alpha	382..436	CDD:214549	28/53 (53%)
		Int_alpha	447..491	CDD:214549	19/43 (44%)
		Integrin_alpha2	482..933	CDD:285619	110/487 (23%)
		Integrin_alpha	1034..1048	CDD:278771	4/13 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335729
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840