DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS5 and if

DIOPT Version :9

Sequence 1:	NP_611808.2	Gene:	ItgaPS5 / 37732	FlyBaseID:	FBgn0034880	Length:	1018	Species:	Drosophila melanogaster
Sequence 2:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster

Alignment Length:	948	Identity:	229/948 - (24%)
Similarity:	375/948 - (39%)	Gaps:	267/948 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LIFLALKYQSNAMNFSPLPNRVIDAPKHLKTRMIQVRSSYFGYSLVIRP-----------TSIFV 60
            ||.|.:...::..|        ||.|.:::.|  |..:|.||:|:.:..           .|:.|
  Fly    20 LILLLIAMSAHGYN--------IDLPSYVRFR--QSSNSMFGFSIAMHKGRSGFYGNQNNVSLIV 74

  Fly    61 GAPRAQSTLESQGSINETGAVYRCPLASGSCSHYVLNDKLN-----------KQFQWLGGSMDGG 114
            |||:..::...|| :.|.|.|::|.|....|.....:.|.|           |.:||||.::..|
  Fly    75 GAPKFDTSRYQQG-VTEAGGVFKCSLNDDDCKLVPFDSKGNNRNVDKEVVDRKSYQWLGATVATG 138

  Fly   115 TKDTDKLLVCAPRF-------------------FVPKN------------KNYGQMR-GICYWVR 147
             :|:|.::.||||:                   |...|            .|:|..| |.|
  Fly   139 -RDSDLVVACAPRYVFHTMTPSRAFRIDPVGTCFTSHNFEEFYEVSPCRTNNWGYHRQGSC---- 198

  Fly   148 DTVADTPPLSDVRTISLIPSQAEEHFMLELGLSAHVTDDNSGFLIGAPGVRSWKGSVLVHRGEDL 212
                                        :.|.||.:..:.|...|||||...|:|...     .:
  Fly   199 ----------------------------QAGFSAAINGNGSRLFIGAPGSWYWQGQTY-----SI 230

  Fly   213 AAQGSYAVK-----------MLDSWDWVK--------------NHFTYVGYALSSGYFSSNNRTS 252
            .....:..|           |..|.|..:              |..:|:||::.:|.|..:.
  Fly   231 PPDAKFPFKPPLYQPFGTGGMASSHDVTRPENQVFSTSESASVNDDSYLGYSMVTGDFDGDR--- 292

  Fly   253 LLYVTTAPSSVLNTGKAYIFDVVGEIV----RKLHVFH--GEQLGEYFGYSVVAEDLNGDGLTDV 311
                    |..:..|.....::||.||    ...::|:  |.|:|||||||:...|::||||.|:
  Fly   293 --------SEDVAIGMPRGGNLVGRIVVNRWNMANIFNITGRQIGEYFGYSLATSDVDGDGLDDL 349

  Fly   312 VVSAPLNALGDS----YDVGAIYVFINKGLFKFEKK----IIRLPLSSGARFGSSLSKVGDINHD 368
            ::.||:....|:    ||||.:|:.:..|..: ||:    .||....|..|||.:|:.:||:|.|
  Fly   350 LIGAPMYTDPDNVEGKYDVGRVYILLQGGPTE-EKRWTTEHIRDGYHSKGRFGLALTTLGDVNGD 413

  Fly   369 GYNDLAVGAPF---AGNGAVFIFLGSEHGLRDEPSQRLDAPSR-EPGPYGAHMFGQGLSRGSDID 429
            ||.|.|||||:   .|.|.|:||.||..|...:|||.:.:... |..|| ...||..||.|.|:|
  Fly   414 GYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLAKPSQIIKSEQLVEGAPY-PRTFGFALSGGLDMD 477

  Fly   430 GNGFNDLAIGAPGAEAVYLYRAYPVVKIHA--TVRSESRAIRPEQET------------ITVTAC 480
            ||.:.|||:||..::.|:::::.||..::|  :..|.|:.|..:..:            :.:|.|
  Fly   478 GNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFASNSKLISLDDRSCQLVRDHKKVPCMLLTTC 542

  Fly   481 YRLETTSKARQMQQQ---ELTFRMTIDELLQRVSFAPMRTNEVSFQAQAGLSGSCRNFSVGVHY- 541
            :    :...|.:.:|   ::::.:...:||....|         |....|  .:.||.::.::|
  Fly   543 W----SYTGRYLPEQLDFDVSWLLDAKKLLNPRMF---------FLRDEG--KNIRNQTIRLNYG 592

  Fly   542 --------------TGGIFTPIDLELHYELAKKIPHSHEAFCESCAVVDP--------LEPK--- 581
                          .....||:::|..|.|....|            :||        |||.
  Fly   593 QKYCLNETVYLLDKVQDKLTPLEVEARYNLRSSRP------------LDPMVRHRRSILEPVIDQ 645

  Fly   582 ----YATGTLSFMTGCAA-HVCVSDLQLSSKDVNSSFIFGSLEVLSFSYEITNSGEPAYVAQFNV 641
                .....::....|.. ::|..||:|....|: .::|||.|.|.....|:|:.|.|:.|.|.:
  Fly   646 NREIVLRDAINIQKNCGPDNICEPDLKLKVSTVD-KYLFGSPEPLVIEVFISNTNEDAFEAAFYM 709

  Fly   642 TSSARLPFAKV---------PGNCR----VRHEVMLCDLNGGRALARGDSESLTIIFDVTQLSGQ 693
            .:...|.|.|:         |..|.    ..:..:.||:  |..|..|......|.....:..|.
  Fly   710 VTPPDLQFRKLQQLGEKKDTPITCSPPTPENNHTLKCDI--GNPLESGKIAHFKISLVPEEKYGS 772

  Fly   694 SLTI----EAAVSSAGMDQNPKDNTMSTTISLREYAEIDASGGPIDGH------------IALKE 742
            |.:.    ||..::.....:..||.:..::.:....::|..|..:..:            .|.||
  Fly   773 SSSYDFYWEANSTNLEKPGSEYDNKIRQSVGIWVDTDLDIKGTSLPDYQLYKADDYKELENATKE 837

  Fly   743 YPYSAEVNNSYEFKSHGPSIIDELTVYVDVPIAYTVTG 780
            .....:|.:.||.:::.||||:|..|::.:|.. |:.|
  Fly   838 DDIGPQVVHIYEIRNNRPSIIEEAEVFIHLPYE-TIVG 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	VCBS	302..375	CDD:338792	31/80 (39%)
		Int_alpha	351..403	CDD:214549	28/54 (52%)
		Int_alpha	417..463	CDD:214549	18/47 (38%)
		Integrin_alpha2	451..836	CDD:337057	80/407 (20%)
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	17/64 (27%)
		Int_alpha	275..>316	CDD:214549	11/51 (22%)
		Int_alpha	398..451	CDD:214549	27/52 (52%)
		Int_alpha	466..>497	CDD:214549	15/30 (50%)
		Integrin_alpha2	499..893	CDD:285619	80/407 (20%)
		DUF2756	<1120..1178	CDD:298627
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439844
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D12256at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950