DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS5 and Itga11

DIOPT Version :9

Sequence 1:	NP_611808.2	Gene:	ItgaPS5 / 37732	FlyBaseID:	FBgn0034880	Length:	1018	Species:	Drosophila melanogaster
Sequence 2:	NP_795896.4	Gene:	Itga11 / 319480	MGIID:	2442114	Length:	1188	Species:	Mus musculus

Alignment Length:	1300	Identity:	286/1300 - (22%)
Similarity:	446/1300 - (34%)	Gaps:	478/1300 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SNAMNFSPLPNRVIDAPKHLKTRMIQVRSSYFGYSLVIRPTS----IFVGAPRAQSTLESQGSIN 76
            ::..|......|||..|.          :::|||::.....|    :.||||     :|:.|. .
Mouse    20 TDTFNMDTRNPRVIAGPS----------AAFFGYTVQQHDISGKKWLVVGAP-----METNGH-Q 68

  Fly    77 ETGAVYRCPLASGSCSHYVLNDKLN------------KQFQWLGGSMDGGTKDTDKLLVCAP--- 126
            :||.||:||:..|:|:      |||            |....||.|:....|| :..|.|:|
Mouse    69 KTGDVYKCPVTQGNCT------KLNLGRVTLSNVSERKDNMRLGLSLATNPKD-NSFLACSPLWS 126

  Fly   127 --------------------------------------------------------RFFVPKNKN 135
                                                                    .|.:...|.
Mouse   127 HECGSSYYTTGMCSRVNSNFRFSKTVAPALQRCQTYMDIVIVLDGSNSIYPWVEVQHFLINILKK 191

  Fly   136 Y----GQMR-GICYW---------------VRDTVA----------------------------- 151
            :    ||:: ||..:               |:|.|.
Mouse   192 FYIGPGQIQVGIVQYGEDAVHEFHLNDYRSVKDVVEAASHIEQRGGTETRTAFGIEFARSEAFQK 256

  Fly   152 -------------------DTPPLSDV-------------------------------RTISLIP 166
                               |:|.|..|                               ..|..|.
Mouse   257 GGRKGAKKVMIVITDGESHDSPDLEKVIRQSEKDNVTRYAVAVLGYYNRRGINPETFLNEIKYIA 321

  Fly   167 SQAEE-HF------------------------------------MLELGLSAHVTDDNSGFLIGA 194
            |..:: ||                                    |.:.|.|:||.:|  |.|:||
Mouse   322 SDPDDKHFFNVTDEAALKDIVDALGDRIFSLEGTNKNETSFGLEMSQTGFSSHVVED--GILLGA 384

  Fly   195 PGVRSWKGSVL--VHRGEDLAAQGSYAVKMLDSWDWVKNHFTYVGYALSSGYFSSNNRTSLLYVT 257
            .|...|.|:||  ...|:.:..:.||..:..:.   :|||..|:||.::|...|...|   :||.
Mouse   385 VGAYDWNGAVLKETSAGKVIPHRESYLKEFPEE---LKNHAAYLGYTVTSVVSSRQGR---VYVA 443

  Fly   258 TAPSSVLNTGKAYIFDVVGEIVRKLH-VFHGEQLGEYFGYSVVAEDLNGDGLTDV-VVSAPLNAL 320
            .|| ...:|||..:|.:.......:| ...|||:|.|||..:.:.|:|.|.:||| :|.||: ..
Mouse   444 GAP-RFNHTGKVILFSMHNNRSLTIHQALRGEQIGSYFGSEITSVDVNDDRVTDVLLVGAPM-YF 506

  Fly   321 GDSYDVGAIYVF-INKGLFKFEKKIIRLPLSSGARFGSSLSKVGDINHDGYNDLAVGAPF--AGN 382
            .:..:.|.:||: :.:..|.:...:........|||||.::.|.|:|.|.|||:.||||.  :..
Mouse   507 SEGRERGKVYVYNLRQNRFVYNGTLKDSHSYQNARFGSCIASVQDLNQDSYNDVVVGAPLEDSHR 571

  Fly   383 GAVFIFLGSEHGLRDEPSQRLDAPSREPG--PYGAHMFGQGLSRGSDIDGNGFNDLAIGAPGAEA 445
            ||::||.|.:..:..:|.||:.|....||  .:|..:.||     .|::.:|..|||:||.| .|
Mouse   572 GAIYIFHGFQTNILKKPMQRITASELAPGLQHFGCSIHGQ-----LDLNEDGLVDLAVGALG-NA 630

  Fly   446 VYLYRAYPVVKIHATVRSESRAIR----------------------------PEQETITVTACYR 482
            |.|: |.|||:|:|::..|...|.                            |..:|.||...|.
Mouse   631 VVLW-ARPVVQINASLHFEPSKINIFHKDCKRNGRDATCLAAFLCFIPIFLAPHFQTATVGIRYN 694

  Fly   483 LETTSKARQMQQQELTFRMTIDELLQRVSFAPMRTNEVSFQAQAGLSGS----CRNFSVGVHYTG 543
             .|..:.|.|.      |..:||            ....|..:|.|..|    |:..:..|..|.
Mouse   695 -ATMDERRYMP------RAHLDE------------GGDQFTNRAVLLSSGQEHCQRINFHVLDTA 740

  Fly   544 GIFTPIDLELHYELAKKIPHSHEAFCESCAVVDPLEPKYATGTLSFMTGC--AAHVCVSDLQLSS 606
            ....|:...:.|.|...         ::..::|...|.....::.|..||  ..| ||.||.|.:
Mouse   741 DYVKPVAFSVEYSLEDP---------DNGPMLDNGWPTTLRVSVPFWNGCNEDEH-CVPDLVLDA 795

  Fly   607 K-DVNSSF-----IFG-----------SLEVLSFSYEIT-----------NSGEPAYVAQFNVTS 643
            : |:.::.     :.|           |.:...|..|.|           |.||.||.|..|::.
Mouse   796 RSDLPTAMEYCQRVLGRPAQDCSSYTLSFDTTVFIIESTRRRVAVEATLENRGENAYSAVLNISQ 860

  Fly   644 SARLPFAK-------------VPGNCRVRHEVMLCDLN------GGRALARGDSESLTIIFDVTQ 689
            |..|.||.             |....|:..:|  |:::      ..:...|.|.|....:|
Mouse   861 SENLQFASLIQKDDSDNSIECVNEERRLHKKV--CNVSYPFFRAKAKVAFRLDFEFSKSVF---- 919

  Fly   690 LSGQSLTIEAAVSSAGMDQNPKDNTMSTTISLREYAEI------DASGGPIDGHIALKEY----- 743
            |....:.:.|...|...|....|||......|:..|::      ..|...:..:.:|:.|
Mouse   920 LHHLQIHLGAGSDSHEQDSTADDNTALLRFHLKYEADVLFTRSSSLSHFEVKANSSLESYDGIGP 984

  Fly   744 PYSA--EVNNSYEFKSHGPSIIDELTVYVDVPIAYTVTGSAGIKSIFNISSLQMQATHGSELVPI 806
            |::.  :|.|...|..||      :.:.:.||||                     ...|:.|:.:
Mouse   985 PFNCVFKVQNLGFFPIHG------VMMKITVPIA---------------------TRGGNRLLML 1022

  Fly   807 KLY--DQTNTL------AKEY---PLEDSSRRANRKRRELQQDQYAIMPDVNISDILTKENLPAN 860
            :.:  ||.||.      :.||   |.|:....| .:|.....|..:|:.::.::        |:.
Mouse  1023 RDFFTDQGNTSCNIWGNSTEYRSTPTEEDLSHA-PQRNHSNSDVVSIICNLRLA--------PSQ 1078

  Fly   861 RTLVLDCLRGN-WTICVRSQMRVQLKPEQPIDLRISFKVDLN-----DFVNTFDYLVIFTNVEMF 919
            .|...  |.|| |...:::     ||..       |.|:.:|     .|.:.|          :|
Mouse  1079 ETSFY--LVGNLWLTSLKA-----LKYR-------SLKITVNAALQRQFHSPF----------IF 1119

  Fly   920 KEGDSTSIALKRNLKPNVIFNYS---ETPLPIWYIILSLIAGHLLLGAMTYILYKLRFFKRGKKE 981
            :|.|.:.         .|.|..|   :..:|||.|:.|.:.|.|||..:...|:||.|||..|::
Mouse  1120 REEDPSR---------QVTFEISKQEDWQVPIWIIVGSTLGGLLLLALLVLALWKLGFFKSAKRK 1175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	VCBS	302..375	CDD:338792	25/74 (34%)
		Int_alpha	351..403	CDD:214549	23/53 (43%)
		Int_alpha	417..463	CDD:214549	19/45 (42%)
		Integrin_alpha2	451..836	CDD:337057	99/489 (20%)
Itga11	NP_795896.4	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	24..85		23/82 (28%)
		Int_alpha	37..86	CDD:214549	18/70 (26%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	91..151		9/60 (15%)
		vWA_integrins_alpha_subunit	163..341	CDD:238746	18/177 (10%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	355..406		16/52 (31%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	411..461		17/56 (30%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	462..527		21/65 (32%)
		Int_alpha	476..523	CDD:214549	16/47 (34%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	528..586		21/57 (37%)
		Int_alpha	538..592	CDD:214549	23/53 (43%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	590..650		26/66 (39%)
		Integrin_alpha2	635..1034	CDD:285619	93/460 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832051
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940