DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS5 and Itga4

DIOPT Version :9

Sequence 1:	NP_611808.2	Gene:	ItgaPS5 / 37732	FlyBaseID:	FBgn0034880	Length:	1018	Species:	Drosophila melanogaster
Sequence 2:	NP_001101207.1	Gene:	Itga4 / 311144	RGDID:	1593249	Length:	1036	Species:	Rattus norvegicus

Alignment Length:	1102	Identity:	268/1102 - (24%)
Similarity:	470/1102 - (42%)	Gaps:	207/1102 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LLFLIFLALKYQ---SNAMNFSPLPNRVIDAPKHLKTRMIQVRSSYFGYSLVIRPTS----IFVG 61
            ::.|::..:.::   .::.|..|....:...|.          .:.||||:|:....    :.||
  Rat    20 VMLLLYFGVHFRVPTGHSYNLDPESALLYQGPS----------GTLFGYSVVLHSHGTKRWLIVG 74

  Fly    62 APRAQSTLESQGSINETGAVYRCPLA---------------SGS-CSHYVLNDKLNKQFQWLGGS 110
            ||.| |.|.:...:| .||:|||.:.               ||. |....|.::.|   ||||.:
  Rat    75 APTA-SWLANASVVN-PGAIYRCRIGKNPNQICEQLQLGSPSGEPCGKTCLEERDN---QWLGVT 134

  Fly   111 MDGGTKDTDKLLVCAPRF---FVPKNKNYGQMRGICYWVRDTVADTPPLSDVRT----------I 162
            :.....:...::.|..|:   |..||.| ....|:||.:.         ||:||          .
  Rat   135 ISRQPGENGSIVTCGHRWKNIFYMKNNN-KLPTGVCYGMP---------SDLRTELSKRMAPCYQ 189

  Fly   163 SLIPSQAEEHFMLELGLSAHVTDDNSGFLIGAPGVRSWKGSVLVHRGEDLAAQGSYAVKMLDSWD 227
            ..:....|.....:.|:|:..|.|.  .::||||...|.|||.|:.    .....|.. .:|..:
  Rat   190 DFVRKFGENFASCQAGISSFYTQDL--IVMGAPGSSYWTGSVFVYN----ITTNKYKA-FVDRQN 247

  Fly   228 WVKNHFTYVGYALSSGYFSSNNRTSLLYVTTAPSSVLNTGKAYIFDVVGEIVRKLHVFHGEQLGE 292
            .|| ..:|:||::.:|:|.:.:.|.:  |..||... ..||||||.:....:..::...|::||.
  Rat   248 QVK-FGSYLGYSVGAGHFRNPHTTEV--VGGAPQHE-QIGKAYIFSIDESELTIVYEMKGKKLGS 308

  Fly   293 YFGYSVVAEDLNGDGLTDVVVSAPLNALGDSYDVGAIYVFINKGLFKFEKKIIRLPLSS---GAR 354
            |||.||.|.|||.||.:|::|.||:.:  ...:.|.::|:||.|:.....::.|:.:.|   .||
  Rat   309 YFGASVCAVDLNADGFSDLLVGAPMQS--TIREEGRVFVYINSGMGAVMVEMERVLVGSDKYAAR 371

  Fly   355 FGSSLSKVGDINHDGYNDLAVGAPFAGN--GAVFIFLGSEHGLRDEPSQRLDAPSREPGPYGAHM 417
            ||.|::.:|||::||:.|:|:|||...:  |||:|:.|...|:....|||::.....   ....|
  Rat   372 FGESMANLGDIDNDGFEDIAIGAPQEDDLRGAVYIYNGRVDGISSTYSQRIEGRQIS---QSLRM 433

  Fly   418 FGQGLSRGSDIDGNGFNDLAIGAPGAEAVYLYRAYPVVKIHATVRSESRAIR-----PEQETITV 477
            |||.:|...|.|.||:.|:|:||..:::..|.|..|||.:.|::.......|     .|...::|
  Rat   434 FGQSISGQIDADNNGYVDVAVGAFQSDSAVLLRTRPVVIVEASLSHPESVNRTKFDCTENGLLSV 498

  Fly   478 TACYRLETTSKARQMQQQ-ELTFRMTIDELLQRVSFAPMR--------TNEVSFQAQAGLSG-SC 532
            ....:|..:.|.:::... .|.:.:::|  :.|.:.:|.|        ::.::...:...|| .|
  Rat   499 CVDLKLCFSYKGKEVPGYIVLFYNVSLD--VHRKAESPSRFYFFSNGTSDMITRSIRVSSSGEKC 561

  Fly   533 RNFSVGVHY-TGGIFTPIDLELHYELAKKI--PHSHEAFCESCAVVDPLEP--------KYATGT 586
            |.....:.. ...|.|||.:|..|.|...:  ..:.|.|       .||:|        .....|
  Rat   562 RTHQAFMRKDVRDILTPIQVEATYHLGHHVITKRNTEEF-------PPLQPILQQKKEKDIIRKT 619

  Fly   587 LSFMTGCAAHVCVSDLQLSSK------DVNSSFI-FGSLEVLSFSYEITNSGEPAYVAQFNVTSS 644
            ::|...||...|.:|||:|:|      ..|.::: .||::.:..:..:.|:|:.||....||...
  Rat   620 INFARFCAYENCSADLQVSAKVGFLKPYENKTYLAVGSMKTIMLNVSLFNAGDDAYETTLNVQLP 684

  Fly   645 ARLPFAKVPG------NCRVRHE----VMLCDLNGGRALARGDSESLTIIFDVTQLS----GQSL 695
            ..|.|.|:..      ||.|...    .:.|.| |...:.|.....::.:.||:.||    ..|:
  Rat   685 TGLYFIKILDLEEKQINCDVTESSGVVKLACSL-GYIYVDRLSRIDISFLLDVSSLSRAHEDLSI 748

  Fly   696 TIEAAVSSAGMDQNPKDNTMSTTISLREYAEIDASGGPIDGHIALKEYPYSA------------E 748
            .:.|:..:.|.....|||.::..|.|| |..:.|    :.|.:....:.|.:            :
  Rat   749 NVHASCENEGKLDQVKDNRVTLVIPLR-YEVMLA----VHGFVTPTSFVYGSSEENEPEMCMAEK 808

  Fly   749 VNNSYEFKSHGPSIIDELTVYVDVPIAYTVTGSAGIKSIFNISSLQMQATHGSELVPIKLYDQTN 813
            :|.::...:.|.|:...::|.:.||.::.....    .:||:  |.:|||.|.  ...:.|.:..
  Rat   809 LNLTFHVINTGISMAPNVSVKIMVPNSFLPRND----KLFNV--LDVQATMGQ--CQFEHYGREC 865

  Fly   814 TLAKEY----PLEDSSRRANRKRRELQQDQYAIMPDVNISDILTKENLPANRTLVLDCLRGNWTI 874
            .||::.    .|.|..:..::..:.|   .|.:..|.:..|.|              |..|....
  Rat   866 ALAQQKGIAGTLTDLVKFLSKTDKRL---LYCMKADRHCLDFL--------------CNFGKMES 913

  Fly   875 CVRSQMRVQL--KP---EQPIDLRISFKVDLNDFVNTFDYLVIFTNVEMFKEGDSTSIALK--RN 932
            ...:.:.:||  :|   |......:.|::....|......:     :|:.|:.:...:.|:  .:
  Rat   914 GKEASVHIQLEGRPSVLEMDETSSLKFEIKATAFPEPHPKV-----IELNKDENIAHVYLEGLHH 973

  Fly   933 LKPNVIFNYSETPLPIWYIILSLIAGHLLLGAMTYILYKLRFFKRGKKEELKRLLEEHRSET 994
            .:|...|.       |..:.:||:.|.::|..::.:::|..||||..|..|:   ||:|.::
  Rat   974 QRPKRHFT-------IVIVTISLLLGLIVLLLISCVMWKAGFFKRQYKSILQ---EENRRDS 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	VCBS	302..375	CDD:338792	27/75 (36%)
		Int_alpha	351..403	CDD:214549	24/56 (43%)
		Int_alpha	417..463	CDD:214549	19/45 (42%)
		Integrin_alpha2	451..836	CDD:337057	94/447 (21%)
Itga4	NP_001101207.1	Int_alpha	52..109	CDD:214549	18/68 (26%)
		Int_alpha	307..355	CDD:214549	21/49 (43%)
		Int_alpha	370..422	CDD:214549	23/51 (45%)
		Int_alpha	433..483	CDD:214549	19/49 (39%)
		Integrin_alpha2	467..906	CDD:285619	99/478 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335747
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D105280at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.950