DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS5 and Itgal

DIOPT Version :9

Sequence 1:	NP_611808.2	Gene:	ItgaPS5 / 37732	FlyBaseID:	FBgn0034880	Length:	1018	Species:	Drosophila melanogaster
Sequence 2:	XP_006230331.1	Gene:	Itgal / 308995	RGDID:	631424	Length:	1161	Species:	Rattus norvegicus

Alignment Length:	1245	Identity:	262/1245 - (21%)
Similarity:	442/1245 - (35%)	Gaps:	399/1245 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LIFLALKYQSNAMNFSPLPNRVIDAPKHLKTRMIQVRSSYFGYSLVIRPTSIFVGAPRAQSTLES 71
            |:.|.|:...||.:::      :|. :|.::.:.|. ..:|||.::.....:.||||
  Rat    10 LLLLGLQLFVNAWSYN------LDT-RHAQSFLTQA-GRHFGYQVLQFGDGVVVGAP-------- 58

  Fly    72 QGSINETGAVYRCPLASGSC-------SH------------------------------------ 93
             |..|.||::|.|..:||||       :|
  Rat    59 -GEGNSTGSLYHCHPSSGSCQPVHLGSNHTSKYLGMTMVTDAAKGSLLACDPGLSRTCDQNPYLS 122

  Fly    94 ---YVLNDKLNKQF--------QWLGGSMD-----GGT-----KDTDKLL--------------- 122
               |:.:..|.|..        :.:.|::|     .|:     ||.:|::
  Rat   123 GLCYLFSQSLGKPILQNRPAYQECMKGNVDLVFLFDGSQSLDKKDFEKIVDFMKDVMRKLSNTSY 187

  Fly   123 ---------VCAPRF----FVPKNKN--------------YGQMRGICYWVRDT----------- 149
                     .|...|    ::..|||              ....|.|.|.|...
  Rat   188 QFAAVQFSTECKTEFTFLDYIKLNKNPDVLLGNVTPMFLLTNTFRAINYVVTHVFKEESGARPDA 252

  Fly   150 ---------------------------------------------------------VADT-PPL 156
                                                                     :.|| ..|
  Rat   253 TKVLVIITDGEASDNGNIDAAQDITRYIIGIGKHFSTTQKQEKLHIFASKPVEEFVKILDTFEKL 317

  Fly   157 SDV-----RTISLIPSQAEE---HFMLEL---GLSAHVTDDNSGFLIGAPGVRSWKGSVL-VHRG 209
            .|:     |.|..|...:::   .|.:||   |:||.::..::  ::||.|.:.|.|..| :|
  Rat   318 KDLFTDLQRKIYAIEGTSKQDLASFNMELSSSGISADLSKGHA--VVGAVGAKDWAGGFLDLH-- 378

  Fly   210 EDLAAQGSYAVKMLDSWDWVKNHFTYVGYALSSGYFSSNNRTSLLYVTTAPSSVLNTGKAYIFDV 274
            |||........:.|.|    .....|:||.::  :.:|.:...|| ...|| ...:.|:..:|..
  Rat   379 EDLEGATFVGQEPLTS----DERGGYLGYTVA--WLTSRSSRPLL-AAGAP-RYQHVGQVLLFQA 435

  Fly   275 --VGEIVRKLHVFHGEQLGEYFGYSVVAEDLNGDGLTD-VVVSAPLNALGDSYDVGAIYVF-INK 335
              .|....:.....|.|:|.|||..:.:.||:.||.|| :::.||| ..|:... |.:.|: ..:
  Rat   436 PEAGGHWNQTQKIEGTQIGSYFGGELCSVDLHQDGETDLLLIGAPL-FYGEQRG-GRVSVYQRRR 498

  Fly   336 GLFKFEKKIIRLPLSSGARFGSSLSKVGDINHDGYNDLAVGAPFAGNGAVFIFLGSEHGLRDEPS 400
            .||:...::...|.....|||:::|.:.|||.||..|:|||||....|||:||.|...|...:.|
  Rat   499 SLFEMVSELQGDPGYPLGRFGAAISALTDINGDGLTDVAVGAPLEEQGAVYIFNGKPGGFSSQSS 563

  Fly   401 QRLDAPSREPGPYGAHMFGQGLSRGSDIDGNGFNDLAIGAPGAEAVYLYRAYPVVKI-------- 457
            ||:  |..:..| |...||:.:....|:.|:...|:.:||.|  .|.:..:.|||.|
  Rat   564 QRI--PGTQVSP-GVRWFGRSIHGVKDLGGDRLADVVVGAEG--QVIVLSSRPVVDIVTELSFSP 623

  Fly   458 -----HATVRSESRAIRPEQETITVTACYRLE-TTSKARQMQQQELTFRMTIDELLQRV-SFAPM 515
                 |....|.| |.:.::|.:.:..|:::. .||:.:......|::.:.:|....|. ...|.
  Rat   624 DEIPVHEVECSYS-ASQEQKEGVKLKVCFQIRPLTSQFQGRLLANLSYTLQLDGHRTRSRGLFPG 687

  Fly   516 RTNEVSFQAQAGLSGSCRNFSVGVHY---TGGIFTPIDLELHYELAKK--IPHSHEAFCESCAVV 575
            .:.|:..........||.:|.  .|:   ...:.:||::.|::.|.::  .|...:...:...::
  Rat   688 GSRELGGNTSVTPDKSCMDFH--FHFPICIQDLISPINVSLNFSLLEEEGSPRDQKGGRDMQPIL 750

  Fly   576 DPLEPKYATGTLSFMTGCAA-HVCVSDLQLSSKDVNSSFIFGSLEVLSFSYEITNSGEPAYVAQF 639
            .| .....|..:.|...|.. ..|.:||.||....:......|...|:..:.:.|.||.||..:.
  Rat   751 RP-SIHAVTKEIPFEKNCGEDKKCEADLALSPPARSGVLRLMSSASLAVEWTLRNLGEDAYWVRL 814

  Fly   640 NVTSSARLPFAKV---------PGNCRVRHE-------VMLCDLNGGRALARGDSESLTIIF--- 685
            ::.....|.|.||         |.:|....|       .:.|::: ......|...:|.::|
  Rat   815 DLDFPRGLSFRKVEMLQPHSQIPVSCEELTEESSLLTKTLKCNVS-SPIFKAGKQMTLQVMFNTL 878

  Fly   686 ------DVTQLSGQSLTIEAAVSSAGMDQNPKDNTMSTTISL----------REYAEIDASGGPI 734
                  |..:|:| ::..|...||.|     |||:.:|.|.:          :|.:.:..|..|
  Rat   879 LNSSWGDFVELNG-TVHCENENSSLG-----KDNSATTRIPVLYPVNILTEDQENSTLYISFTP- 936

  Fly   735 DGHIALKEYPYSAEVNNSYEFKSHGPSIIDE----LTVYVDV-------PIAYTVTGSAGIKSIF 788
                   :.|.:.:|.:.|:.:.. ||..|.    |...|:|       |||:|.|
  Rat   937 -------KGPKTQQVQHIYKVRIQ-PSAYDHNMPALEALVEVPQPHSEGPIAHTWT--------- 984

  Fly   789 NISSLQMQATHGSELVPIKLYDQTNTLAKEYPLEDSSRRANRKR--RELQQDQYAIMPDVNISDI 851
                     .|...||                   :..|.:.|:  ||.:|
  Rat   985 ---------VHTDPLV-------------------TCHREDLKKPTREAEQ-------------- 1007

  Fly   852 LTKENLPANRTLVLDCLRGNWTICVRSQMRVQLKPEQPIDLRISFKVDLNDFVNTFDYL------ 910
                          .||.|       .|.|..:...|...:|::..|:|::.:.....|
  Rat  1008 --------------PCLPG-------VQFRCPIVFRQETFIRVAGTVELSEKIKASSTLSLCSSL 1051

  Fly   911 -VIFTNVEMFKEGDSTSIALKRNLKPNVIFNYSETPLPIWYIILSLIAGHLLLGAMTYILYKLRF 974
             |.|.:.:.|....|.:...:..:|.::|  |.:..|.::  :||.|.|.|||..:...|||:.|
  Rat  1052 SVSFNSSKHFHLYGSKASKAQVLMKVDMI--YEKEMLHLY--VLSGIGGLLLLSLIFLALYKVGF 1112

  Fly   975 FKRGKKEELK 984
            |||..||:::
  Rat  1113 FKRKLKEKME 1122

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	VCBS	302..375	CDD:338792	25/74 (34%)
		Int_alpha	351..403	CDD:214549	24/51 (47%)
		Int_alpha	417..463	CDD:214549	14/58 (24%)
		Integrin_alpha2	451..836	CDD:337057	89/453 (20%)
Itgal	XP_006230331.1	Int_alpha	38..81	CDD:214549	17/52 (33%)
		vWFA	151..320	CDD:294047	17/168 (10%)
		Int_alpha	398..448	CDD:214549	11/53 (21%)
		Int_alpha	453..499	CDD:214549	16/47 (34%)
		Int_alpha	514..566	CDD:214549	24/51 (47%)
		Int_alpha	577..621	CDD:214549	13/45 (29%)
		Integrin_alpha2	609..977	CDD:285619	77/387 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335718
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.940