DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS5 and Itgav

DIOPT Version :9

Sequence 1:	NP_611808.2	Gene:	ItgaPS5 / 37732	FlyBaseID:	FBgn0034880	Length:	1018	Species:	Drosophila melanogaster
Sequence 2:	XP_038962373.1	Gene:	Itgav / 296456	RGDID:	1310613	Length:	1043	Species:	Rattus norvegicus

Alignment Length:	1173	Identity:	282/1173 - (24%)
Similarity:	466/1173 - (39%)	Gaps:	317/1173 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LLFLIFLALKYQSNAMNFSPLPNRVIDAPKHLKTRMIQVRSSYFGYSL--VIRPTS----IFVGA 62
            ||.|:.|.|.:   |.:|    |..:::|    ........||||:::  .:..||    :.|||
  Rat    17 LLLLLGLLLPF---AGSF----NLDVESP----AEYAGPEGSYFGFAVDFFVPSTSSRMFLLVGA 70

  Fly    63 PRAQSTLESQGSINETGAVYRCPLASG-SCS----------HYVLNDKLN-KQFQWLGGSMDGGT 115
            |:|.:|   |..|.|.|.|.:|..:|. .|.          .|..:|.|. |..||.|.|:   .
  Rat    71 PKANTT---QPGIIEGGQVLKCDCSSSRRCQPIEFDSTGNRDYAKDDPLEFKSHQWFGASV---R 129

  Fly   116 KDTDKLLVCAPRF-FVPKNKNYGQMRGICYWVRDTVADTPPLSD-VRTISLIPSQAEEHFMLELG 178
            ...||:|.|||.: :..:.|...:..|.|:           |.| .:|:...|.:
  Rat   130 SKQDKILACAPLYHWRTEMKQEREPVGTCF-----------LQDGTKTVEYAPCR---------- 173

  Fly   179 LSAHVTDDNSGF---------------LIGAPGVRSWKGSVLVHRGEDLAAQ---GSYAVK---- 221
             |.::..|..||               |:|.||...|:|.::..:..::.::   ..|::|
  Rat   174 -SKNIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIISKYDPNVYSIKYNNQ 237

  Fly   222 --------MLDSWDWVKNHFTYVGYALSSGYFSSNNRTSLLYVTTAPSSVLNTGKAYIFDVVGEI 278
                    :.|.        :|:||:::.|.|:.:....  :|:..|.:....|..||:|  |:.
  Rat   238 LATRTAQAIFDD--------SYLGYSVAVGDFNGDGIED--FVSGVPRAARTLGMVYIYD--GKN 290

  Fly   279 VRKLHVFHGEQLGEYFGYSVVAEDLNGDGLTDVVVSAPL----NALGDSYDVGAIYVFINKGLFK 339
            :..||.|.|||:..|||:||.|.|:|||...||.:.|||    .:.|...:||.:.|.:.:....
  Rat   291 MSSLHNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGD 355

  Fly   340 FEKKIIRLPLSSG----ARFGSSLSKVGDINHDGYNDLAVGAPFAG---NGAVFIFLGSEHGLRD 397
            |:...:     :|    |||||:::.:||::.||:||:|:.||:.|   .|.|:||.|...||..
  Rat   356 FQTTKL-----NGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGLVYIFNGRSTGLNS 415

  Fly   398 EPSQRLD----APSREPGPYGAHMFGQGLSRGSDIDGNGFNDLAIGAPGAEAVYLYRAYPVVKIH 458
            .|||.|.    |.|..|.      ||..:...:|:|.||:.||.:||.|.:...||||.|||.::
  Rat   416 VPSQILQGQWAAQSMPPS------FGYSMKGATDVDRNGYPDLVVGAFGVDRAVLYRARPVVTVN 474

  Fly   459 A------TVRSESRAIRPEQETITVTACYRLETTSKA--RQMQQQELTFR--MTIDEL-----LQ 508
            |      ::.::...|.|...|....:|:.:....||  :....::|.|:  :.:|:|     ::
  Rat   475 AGLEVYPSILNQDNKICPLPGTALKVSCFNVRFCLKADGKGTLPRKLNFQVELLLDKLKQKGAIR 539

  Fly   509 RVSFAPMRTNEVSFQAQAGLSGSCRNFSVGVHYTGG-------------------IFTPIDLELH 554
            |..|...|:           .|..::.:|   :.||                   ..|||.:.:.
  Rat   540 RALFLHNRS-----------PGHSKDMTV---FRGGQTQCEELVAYLRDESEFRDKLTPITIFME 590

  Fly   555 YELAKKIPHSHEAFCESCAVVDPLEPKYATGTLS----FMTGCAA-HVCVSDLQLSSKDVNSSFI 614
            |.|.::.       ......:.|:..::....:|    .:..|.. :||...|::|.........
  Rat   591 YRLDQRT-------AADATGLQPILNQFTPANVSRQAHILLDCGEDNVCKPKLEVSVDSDQKKIY 648

  Fly   615 FGSLEVLSFSYEITNSGEPAYVAQFNVTSSARLPFAKVPGN--------CRVRHE----VMLCDL 667
            .|....|:.:.:..|.||.||.|:..|:...:..|..|..|        |..:.|    .::|||
  Rat   649 IGDDNPLTLTVKAQNQGEGAYEAELIVSIPPQADFIGVVRNNEALARLSCAFKTENQTRQVVCDL 713

  Fly   668 NGGRALARGDSESLTIIFDVTQLS--GQSLTIEAAVSSAGMDQNPKDN---TMSTTISLREYAEI 727
              |..:..|......:.|.|.|.|  ..|:..:..:.|:    |..||   .:|..:.|...|.:
  Rat   714 --GNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLKIQSS----NSFDNVSPVVSYKVDLAVLAAV 772

  Fly   728 DASGGPIDGHIAL-------KEYPYSAE-----VNNSYEFKSHGPSIIDELTVYVDVPIAYTVTG 780
            :..|.....||.|       ||.|.:.|     |.:.||.:::|||...:..:.:..|..|
  Rat   773 EIRGVSSPDHIFLPIPNWEYKETPETEEDVGPVVQHIYELRNNGPSSFSKAILNLQWPYKY---- 833

  Fly   781 SAGIKSIFNISSL----------QMQATHGSELVP--IKLYDQTNTLAKEYPLEDSSRRANRKRR 833
                    |.::|          .|..|..:|:.|  ||..::.:|.|     |...|.....:|
  Rat   834 --------NNNTLLYILHYDIDGPMNCTADTEINPLRIKTPEKNDTAA-----EQGGRNHLITKR 885

  Fly   834 ELQQDQYAIMPDVNISDILTKENLPANRTLVLDCLRGNWTICVRSQMRVQLKPEQPIDLRISFKV 898
            :|...:         .|:.|           |.|   ....|::...:|.             ::
  Rat   886 DLSLSE---------GDVHT-----------LGC---GTAQCLQITCQVG-------------RL 914

  Fly   899 DLNDFVNTFDYLVIFTNVEMFKEGDSTSIALKRNLKPNVI-FNYSETPL---------------- 946
            |.......:...:::|...|.||..:.|.:||.:...|:| |.|...|:
  Rat   915 DRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNIIEFPYKNLPIEDLFNSTLVTTNITWG 979

  Fly   947 --------PIWYIILSLIAGHLLLGAMTYILYKLRFFKRGKKEELKRLLEEHRSETKEPATDCEG 1003
                    |:|.|||:::||.|||..:.:::|::.||||.:..:     ||...|..:|..:.||
  Rat   980 IQPAPMPVPVWVIILAVLAGLLLLAVLVFVMYRMGFFKRVRPPQ-----EEQEREQLQPHENGEG 1039

  Fly  1004 NQE 1006
            |.|
  Rat  1040 NSE 1042

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	VCBS	302..375	CDD:338792	26/80 (33%)
		Int_alpha	351..403	CDD:214549	26/58 (45%)
		Int_alpha	417..463	CDD:214549	19/51 (37%)
		Integrin_alpha2	451..836	CDD:337057	94/464 (20%)
Itgav	XP_038962373.1	Int_alpha	46..103	CDD:214549	20/59 (34%)
		WD40 repeat	126..183	CDD:293791	16/81 (20%)
		WD40 repeat	188..248	CDD:293791	8/59 (14%)
		VCBS	221..271	CDD:404411	8/59 (14%)
		Int_alpha	248..>288	CDD:214549	12/51 (24%)
		WD40 repeat	254..298	CDD:293791	12/47 (26%)
		Int_alpha	302..355	CDD:214549	19/52 (37%)
		WD40 repeat	307..362	CDD:293791	18/59 (31%)
		Int_alpha	367..421	CDD:214549	25/53 (47%)
		WD40 repeat	371..422	CDD:293791	22/50 (44%)
		Int_alpha	434..476	CDD:214549	18/41 (44%)
		Integrin_alpha2	467..909	CDD:400650	100/508 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335694
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840