Protein Alignment ItgaPS5 and Itgav

DIOPT Version :10

• Sequence 1: NP_611808.2
• Gene: ItgaPS5 / 37732
• FlyBaseID: FBgn0034880
• Length: 1018
• Species: Drosophila melanogaster
• Sequence 2: NP_001385621.1
• Gene: Itgav / 296456
• RGDID: 1310613
• Length: 1043
• Species: Rattus norvegicus
• Alignment Length: 1173
• Identity: 282/1173 - (24%)
• Similarity: 466/1173 - (39%)
• Gaps: 317/1173 - (27%)

  Fly     4 LLFLIFLALKYQSNAMNFSPLPNRVIDAPKHLKTRMIQVRSSYFGYSL--VIRPTS----IFVGA 62
            ||.|:.|.|.:   |.:|    |..:::|    ........||||:::  .:..||    :.|||
  Rat    17 LLLLLGLLLPF---AGSF----NLDVESP----AEYAGPEGSYFGFAVDFFVPSTSSRMFLLVGA 70

  Fly    63 PRAQSTLESQGSINETGAVYRCPLASG-SCS----------HYVLNDKLN-KQFQWLGGSMDGGT 115
            |:|.:|   |..|.|.|.|.:|..:|. .|.          .|..:|.|. |..||.|.|:   .
  Rat    71 PKANTT---QPGIIEGGQVLKCDCSSSRRCQPIEFDSTGNRDYAKDDPLEFKSHQWFGASV---R 129

  Fly   116 KDTDKLLVCAPRF-FVPKNKNYGQMRGICYWVRDTVADTPPLSD-VRTISLIPSQAEEHFMLELG 178
            ...||:|.|||.: :..:.|...:..|.|:           |.| .:|:...|.:
  Rat   130 SKQDKILACAPLYHWRTEMKQEREPVGTCF-----------LQDGTKTVEYAPCR---------- 173

  Fly   179 LSAHVTDDNSGF---------------LIGAPGVRSWKGSVLVHRGEDLAAQ---GSYAVK---- 221
             |.::..|..||               |:|.||...|:|.::..:..::.::   ..|::|
  Rat   174 -SKNIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIISKYDPNVYSIKYNNQ 237

  Fly   222 --------MLDSWDWVKNHFTYVGYALSSGYFSSNNRTSLLYVTTAPSSVLNTGKAYIFDVVGEI 278
                    :.|.        :|:||:::.|.|:.:....  :|:..|.:....|..||:|  |:.
  Rat   238 LATRTAQAIFDD--------SYLGYSVAVGDFNGDGIED--FVSGVPRAARTLGMVYIYD--GKN 290

  Fly   279 VRKLHVFHGEQLGEYFGYSVVAEDLNGDGLTDVVVSAPL----NALGDSYDVGAIYVFINKGLFK 339
            :..||.|.|||:..|||:||.|.|:|||...||.:.|||    .:.|...:||.:.|.:.:....
  Rat   291 MSSLHNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGD 355

  Fly   340 FEKKIIRLPLSSG----ARFGSSLSKVGDINHDGYNDLAVGAPFAG---NGAVFIFLGSEHGLRD 397
            |:...:     :|    |||||:::.:||::.||:||:|:.||:.|   .|.|:||.|...||..
  Rat   356 FQTTKL-----NGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGLVYIFNGRSTGLNS 415

  Fly   398 EPSQRLD----APSREPGPYGAHMFGQGLSRGSDIDGNGFNDLAIGAPGAEAVYLYRAYPVVKIH 458
            .|||.|.    |.|..|.      ||..:...:|:|.||:.||.:||.|.:...||||.|||.::
  Rat   416 VPSQILQGQWAAQSMPPS------FGYSMKGATDVDRNGYPDLVVGAFGVDRAVLYRARPVVTVN 474

  Fly   459 A------TVRSESRAIRPEQETITVTACYRLETTSKA--RQMQQQELTFR--MTIDEL-----LQ 508
            |      ::.::...|.|...|....:|:.:....||  :....::|.|:  :.:|:|     ::
  Rat   475 AGLEVYPSILNQDNKICPLPGTALKVSCFNVRFCLKADGKGTLPRKLNFQVELLLDKLKQKGAIR 539

  Fly   509 RVSFAPMRTNEVSFQAQAGLSGSCRNFSVGVHYTGG-------------------IFTPIDLELH 554
            |..|...|:           .|..::.:|   :.||                   ..|||.:.:.
  Rat   540 RALFLHNRS-----------PGHSKDMTV---FRGGQTQCEELVAYLRDESEFRDKLTPITIFME 590

  Fly   555 YELAKKIPHSHEAFCESCAVVDPLEPKYATGTLS----FMTGCAA-HVCVSDLQLSSKDVNSSFI 614
            |.|.::.       ......:.|:..::....:|    .:..|.. :||...|::|.........
  Rat   591 YRLDQRT-------AADATGLQPILNQFTPANVSRQAHILLDCGEDNVCKPKLEVSVDSDQKKIY 648

  Fly   615 FGSLEVLSFSYEITNSGEPAYVAQFNVTSSARLPFAKVPGN--------CRVRHE----VMLCDL 667
            .|....|:.:.:..|.||.||.|:..|:...:..|..|..|        |..:.|    .::|||
  Rat   649 IGDDNPLTLTVKAQNQGEGAYEAELIVSIPPQADFIGVVRNNEALARLSCAFKTENQTRQVVCDL 713

  Fly   668 NGGRALARGDSESLTIIFDVTQLS--GQSLTIEAAVSSAGMDQNPKDN---TMSTTISLREYAEI 727
              |..:..|......:.|.|.|.|  ..|:..:..:.|:    |..||   .:|..:.|...|.:
  Rat   714 --GNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLKIQSS----NSFDNVSPVVSYKVDLAVLAAV 772

  Fly   728 DASGGPIDGHIAL-------KEYPYSAE-----VNNSYEFKSHGPSIIDELTVYVDVPIAYTVTG 780
            :..|.....||.|       ||.|.:.|     |.:.||.:::|||...:..:.:..|..|
  Rat   773 EIRGVSSPDHIFLPIPNWEYKETPETEEDVGPVVQHIYELRNNGPSSFSKAILNLQWPYKY---- 833

  Fly   781 SAGIKSIFNISSL----------QMQATHGSELVP--IKLYDQTNTLAKEYPLEDSSRRANRKRR 833
                    |.::|          .|..|..:|:.|  ||..::.:|.|     |...|.....:|
  Rat   834 --------NNNTLLYILHYDIDGPMNCTADTEINPLRIKTPEKNDTAA-----EQGGRNHLITKR 885

  Fly   834 ELQQDQYAIMPDVNISDILTKENLPANRTLVLDCLRGNWTICVRSQMRVQLKPEQPIDLRISFKV 898
            :|...:         .|:.|           |.|   ....|::...:|.             ::
  Rat   886 DLSLSE---------GDVHT-----------LGC---GTAQCLQITCQVG-------------RL 914

  Fly   899 DLNDFVNTFDYLVIFTNVEMFKEGDSTSIALKRNLKPNVI-FNYSETPL---------------- 946
            |.......:...:::|...|.||..:.|.:||.:...|:| |.|...|:
  Rat   915 DRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNIIEFPYKNLPIEDLFNSTLVTTNITWG 979

  Fly   947 --------PIWYIILSLIAGHLLLGAMTYILYKLRFFKRGKKEELKRLLEEHRSETKEPATDCEG 1003
                    |:|.|||:::||.|||..:.:::|::.||||.:..:     ||...|..:|..:.||
  Rat   980 IQPAPMPVPVWVIILAVLAGLLLLAVLVFVMYRMGFFKRVRPPQ-----EEQEREQLQPHENGEG 1039

  Fly  1004 NQE 1006
            |.|
  Rat  1040 NSE 1042

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	FG-GAP	294..332	CDD:460357	17/41 (41%)
		Int_alpha	351..403	CDD:214549	26/58 (45%)
		Int_alpha	417..463	CDD:214549	19/51 (37%)
		Integrin_alpha2	453..837	CDD:462478	94/463 (20%)
Itgav	NP_001385621.1	Int_alpha	46..103	CDD:214549	20/59 (34%)
		WD40 repeat	126..183	CDD:293791	16/81 (20%)
		WD40 repeat	188..248	CDD:293791	8/59 (14%)
		FG-GAP_3	221..271	CDD:433275	8/59 (14%)
		Int_alpha	248..>288	CDD:214549	12/51 (24%)
		WD40 repeat	254..298	CDD:293791	12/47 (26%)
		Int_alpha	302..355	CDD:214549	19/52 (37%)
		WD40 repeat	307..362	CDD:293791	18/59 (31%)
		Int_alpha	367..421	CDD:214549	25/53 (47%)
		WD40 repeat	371..422	CDD:293791	22/50 (44%)
		Int_alpha	434..476	CDD:214549	18/41 (44%)
		Integrin_alpha2	468..909	CDD:462478	99/507 (20%)