DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS5 and Itga8

DIOPT Version :9

Sequence 1:	NP_611808.2	Gene:	ItgaPS5 / 37732	FlyBaseID:	FBgn0034880	Length:	1018	Species:	Drosophila melanogaster
Sequence 2:	XP_006497538.1	Gene:	Itga8 / 241226	MGIID:	109442	Length:	1079	Species:	Mus musculus

Alignment Length:	1134	Identity:	279/1134 - (24%)
Similarity:	438/1134 - (38%)	Gaps:	291/1134 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 SYFGYSLVI-----RPTSIFVGAPRAQSTLESQGSINETGAVYRCPL---ASGSCSHYVLNDKLN 101
            |||||||..     |..|:.||||:|.:   ||..|.|.||||.||.   .|..|.....:...|
Mouse    54 SYFGYSLDFYIPDARTASVLVGAPKANT---SQPDIVEGGAVYYCPWPSERSAQCKQIPFDTTNN 115

  Fly   102 KQF--------------QWLGGSMDGGTKDTDKLLVCAPRFFVPKNKNYGQMR--------GICY 144
            ::.              ||.|.::   .....|::.|||.:      ::..::        |.||
Mouse   116 RKIRVNGTKEPIEFKSNQWFGATV---RAHKGKVVACAPLY------HWRTLKPNPAKDPVGTCY 171

  Fly   145 WVRDTVADTPPLSDVRTISLIPSQAEEHFMLELGLSAHVTDDNSGFLIGAPGVRSWKGSVLVHRG 209
            ......:.....|..|..:..|   |.....:.|.|.... .|...::|.||...|:|.|:....
Mouse   172 VAIQNFSAYAEHSPCRNSNADP---EGQGYCQAGFSLDFY-KNGDLIVGGPGSFYWQGQVITVSI 232

  Fly   210 EDLAAQGSY--------AVKMLD----SWDWVKNHFTYVGYALSSGYFSSNNRTSLLYVTTAPSS 262
            .|:.|..|:        |.|..|    |:|     .:|:||::::|.|:.:::..|  |...|..
Mouse   233 ADIIANYSFKDILRKLAAEKQTDVAPASYD-----DSYLGYSVAAGEFTGDSQQEL--VAGIPRG 290

  Fly   263 VLNTGKAYIFDVVGEIVRKLHVFHGEQLGEYFGYSVVAEDLNGDGLTDVVVSAPL----NALGDS 323
            ..|.|  |:..:....:..:..|.|||:..||||:||..|:|.||:.|::|.|||    ....:.
Mouse   291 AQNFG--YVSIINSTDMTFIQNFTGEQMASYFGYTVVVSDVNNDGMDDILVGAPLFMEREFESNP 353

  Fly   324 YDVGAIYVFINKGLFKFEKKIIRLPLSSGARFGSSLSKVGDINHDGYNDLAVGAPFAG---NGAV 385
            .:||.:|:::......|:...:.....:..|||||::.:||:|.|||||:|:|.||||   .|.|
Mouse   354 REVGQVYLYLQASALLFQDPQVLTGTETFGRFGSSVAHLGDLNQDGYNDIAIGVPFAGKDQRGKV 418

  Fly   386 FIFLGSEHGLRDEPSQRLDAPSREPGPYGAHM----FGQGLSRGSDIDGNGFNDLAIGAPGAEAV 446
            .|:.|:..||..:|||.|.      |.:|:..    ||..|...:|||.|.:.||.:||.|...|
Mouse   419 LIYNGNPRGLHSKPSQVLQ------GIWGSQTIPSGFGFSLRGDADIDKNDYPDLLVGAFGKGKV 477

  Fly   447 YLYRAYPVVKIHATVRSESRAIRPEQETI------TVTACYRLET-TSKARQMQQQELTF--RMT 502
            .:|||.|||.:.|.:......|..|.:|.      |..||:.:.. .|.|.|.....:..  .:.
Mouse   478 AVYRARPVVTVDAQLLLHPMIINLENKTCQIPEFPTPVACFSVRVCASIAGQSISNTIALLAEVQ 542

  Fly   503 IDEL-----LQRVSFAPMRTNEVSF----QAQAGLSGSCRNFSVGVHYTGGI---FTPIDLELHY 555
            :|.|     ::|..|.....:..:|    :.|..|  .|::|.|.:......   .:||::.|:|
Mouse   543 LDFLKQKGAIKRTLFLHNHQSHFTFPFVMKQQKSL--HCQDFMVYLRDETEFRDKLSPINISLNY 605

  Fly   556 ELAKKIPHSHEAFCESCAVVDPLEPKY----ATGTLSFMTGCAA-HVCVSDLQLSSKDVNSSFIF 615
            .|      ....|.:|.. |.|:...|    .|.....:..|.. ::||.||:||::......|.
Mouse   606 SL------DDSTFKDSLE-VKPILNHYRDNVVTEQAHILVDCGEDNLCVPDLKLSARPDKHQIII 663

  Fly   616 GSLEVLSFSYEITNSGEPAYVAQFNVTSSARLPFAKV--------PGNCRVRHE----VMLCDLN 668
            |....|.......|.||.||.|:..|.......:..:        |.:|..:.|    :::|||
Mouse   664 GDENHLMLIINARNEGEGAYEAELFVIIPEEADYVGIERNNKGLRPLSCEYKMENVTRMVVCDL- 727

  Fly   669 GGRALARGDSESLTIIFDVTQL--SGQSLTIEAAVSSAGMDQNPKDNTMSTTISLREYAEIDASG 731
             |..:..|.:.||.:.|.|.:|  :..|:..:..:.|:..| ||..|.....|::...|:::..|
Mouse   728 -GNPMVTGTNFSLGLRFAVPRLEKTNMSINFDLQIRSSNKD-NPDSNFERVQINITAIAQVEIRG 790

  Fly   732 GPIDGHIAL-------KEYPYSAE-----VNNSYEFKSHGPSII--------------DELTVYV 770
            ......|.|       ::.|:..|     |.:.||..:.|||.|              ||..:|:
Mouse   791 VSHPPQIVLPIHNWEPEKKPHKEEEVGPLVEHIYELHNIGPSTISDSILDVGWPFSARDEFLLYI 855

  Fly   771 --------------------------------------------------DVPIAYTVTGS-AGI 784
                                                              |||:......| |.|
Mouse   856 FHLQTLGPLQCQTNPEINPQDIKPAASPEDTPELSAFLRNATIPHLVRKRDVPVVQLHRQSPARI 920

  Fly   785 KSIFNISSLQMQAT----HGSELVPIKLYDQ--TNTLAKEYPLEDSSRRANRKRRELQQDQYAIM 843
            .:..||..||:...    .|.|...:|:..:  .:|..||..:|::|:....|..:.:.|.||:.
Mouse   921 LNCTNIDCLQISCAVGRLGGGESAVLKVRSRLWAHTFLKEISVEETSQEQLVKTLKRKNDHYALA 985

  Fly   844 PDVNISDILTKENLPANRTLVLDCLRGNWTICVRSQMRVQLKP--EQPIDLRISFKVDLNDFVNT 906
            ..|:                                ..|:..|  |||..|
Mouse   986 SLVS--------------------------------FEVKKMPYKEQPAKL-------------- 1004

  Fly   907 FDYLVIFTNVEMFKEGDSTSIALKRNL---KPNVIFNYSETPLPIWYIILSLIAGHLLLGAMTYI 968
                            .:.|.|:|.::   .|||.|:     :|:|.|||:::.|.|:|..:|..
Mouse  1005 ----------------PAGSTAVKTSVIWATPNVSFS-----IPLWVIILAILLGLLVLAILTLA 1048

  Fly   969 LYKLRFFKRGKKEELKRLLEEHRSETKEP 997
            |:|..||.|.:..:.:....|..:..|.|
Mouse  1049 LWKCGFFDRARPPQDEMTDREQLTSDKTP 1077

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	VCBS	302..375	CDD:338792	26/76 (34%)
		Int_alpha	351..403	CDD:214549	28/54 (52%)
		Int_alpha	417..463	CDD:214549	20/49 (41%)
		Integrin_alpha2	451..836	CDD:337057	107/507 (21%)
Itga8	XP_006497538.1	Int_alpha	53..111	CDD:214549	26/59 (44%)
		Int_alpha	316..>364	CDD:214549	18/47 (38%)
		Int_alpha	382..436	CDD:214549	28/53 (53%)
		Int_alpha	447..491	CDD:214549	19/43 (44%)
		Integrin_alpha2	482..933	CDD:369878	98/462 (21%)
		Integrin_alpha	1051..1065	CDD:334029	4/13 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832057
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840