DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS5 and ITGA11

DIOPT Version :9

Sequence 1:	NP_611808.2	Gene:	ItgaPS5 / 37732	FlyBaseID:	FBgn0034880	Length:	1018	Species:	Drosophila melanogaster
Sequence 2:	NP_001004439.1	Gene:	ITGA11 / 22801	HGNCID:	6136	Length:	1188	Species:	Homo sapiens

Alignment Length:	1306	Identity:	284/1306 - (21%)
Similarity:	452/1306 - (34%)	Gaps:	487/1306 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 HLKTRMIQV----RSSYFGYSLVIRPTS----IFVGAPRAQSTLESQGSINETGAVYRCPLASGS 90
            ::.||..:|    |:::|||::.....|    :.||||     ||:.| ..:||.||:||:..|:
Human    24 NMDTRKPRVIPGSRTAFFGYTVQQHDISGNKWLVVGAP-----LETNG-YQKTGDVYKCPVIHGN 82

  Fly    91 CSHYVLNDKLN------------KQFQWLGGSMDGGTKDTDKLLVCAP----------------- 126
            |:      |||            |....||.|:....|| :..|.|:|
Human    83 CT------KLNLGRVTLSNVSERKDNMRLGLSLATNPKD-NSFLACSPLWSHECGSSYYTTGMCS 140

  Fly   127 ------------------------------------------RFFVPKNKNY----GQMR-GICY 144
                                                      .|.:...|.:    ||:: |:..
Human   141 RVNSNFRFSKTVAPALQRCQTYMDIVIVLDGSNSIYPWVEVQHFLINILKKFYIGPGQIQVGVVQ 205

  Fly   145 W---------------VRDTVA------------------------------------------- 151
            :               |:|.|.
Human   206 YGEDVVHEFHLNDYRSVKDVVEAASHIEQRGGTETRTAFGIEFARSEAFQKGGRKGAKKVMIVIT 270

  Fly   152 -----DTPPLSDV-------------------------------RTISLIPSQAEE-HF------ 173
                 |:|.|..|                               ..|..|.|..:: ||
Human   271 DGESHDSPDLEKVIQQSERDNVTRYAVAVLGYYNRRGINPETFLNEIKYIASDPDDKHFFNVTDE 335

  Fly   174 ------------------------------MLELGLSAHVTDDNSGFLIGAPGVRSWKGSVL--V 206
                                          |.:.|.|:||.:|  |.|:||.|...|.|:||  .
Human   336 AALKDIVDALGDRIFSLEGTNKNETSFGLEMSQTGFSSHVVED--GVLLGAVGAYDWNGAVLKET 398

  Fly   207 HRGEDLAAQGSYAVKMLDSWDWVKNHFTYVGYALSSGYFSSNNRTSLLYVTTAPSSVLNTGKAYI 271
            ..|:.:..:.||..:..:.   :|||..|:||.::|...|...|   :||..|| ...:|||..:
Human   399 SAGKVIPLRESYLKEFPEE---LKNHGAYLGYTVTSVVSSRQGR---VYVAGAP-RFNHTGKVIL 456

  Fly   272 FDVVGEIVRKLH-VFHGEQLGEYFGYSVVAEDLNGDGLTDV-VVSAPLNALGDSYDVGAIYVF-I 333
            |.:.......:| ...|:|:|.|||..:.:.|::|||:||| :|.||: ...:..:.|.:||: :
Human   457 FTMHNNRSLTIHQAMRGQQIGSYFGSEITSVDIDGDGVTDVLLVGAPM-YFNEGRERGKVYVYEL 520

  Fly   334 NKGLFKFEKKIIRLPLSSGARFGSSLSKVGDINHDGYNDLAVGAPFAGN--GAVFIFLGSEHGLR 396
            .:.||.:...:........||||||::.|.|:|.|.|||:.||||...|  ||::||.|....:.
Human   521 RQNLFVYNGTLKDSHSYQNARFGSSIASVRDLNQDSYNDVVVGAPLEDNHAGAIYIFHGFRGSIL 585

  Fly   397 DEPSQRLDAPSREPG--PYGAHMFGQGLSRGSDIDGNGFNDLAIGAPGAEAVYLYRAYPVVKIHA 459
            ..|.||:.|.....|  .:|..:.||     .|::.:|..|||:||.| .||.|: :.|||:|:|
Human   586 KTPKQRITASELATGLQYFGCSIHGQ-----LDLNEDGLIDLAVGALG-NAVILW-SRPVVQINA 643

  Fly   460 TVRSESRAIR----------------------------PEQETITVTACYRLETTSKARQMQQQE 496
            ::..|...|.                            |..:|.||...|.       ..|.::.
Human   644 SLHFEPSKINIFHRDCKRSGRDATCLAAFLCFTPIFLAPHFQTTTVGIRYN-------ATMDERR 701

  Fly   497 LTFRMTIDELLQRVSFAPMRTNEVSFQAQAGLSGS----CRNFSVGVHYTGGIFTPIDLELHYEL 557
            .|.|..:||...|            |..:|.|..|    |...:..|..|.....|:...:.|.|
Human   702 YTPRAHLDEGGDR------------FTNRAVLLSSGQELCERINFHVLDTADYVKPVTFSVEYSL 754

  Fly   558 AKKIPHSHEAFCESCAVVDPLEPKYATGTLSFMTGC--AAHVCVSDLQLSSK------------- 607
            ...         :...::|...|.....::.|..||  ..| ||.||.|.::
Human   755 EDP---------DHGPMLDDGWPTTLRVSVPFWNGCNEDEH-CVPDLVLDARSDLPTAMEYCQRV 809

  Fly   608 ---------------DVNSSFIFGSLEVLSFSYEITNSGEPAYVAQFNVTSSARLPFAKV----- 652
                           |.....|..:.:.::....:.|.||.||....|::.||.|.||.:
Human   810 LRKPAQDCSAYTLSFDTTVFIIESTRQRVAVEATLENRGENAYSTVLNISQSANLQFASLIQKED 874

  Fly   653 -PG-----NCRVRHEVMLCDLN------GGRALARGDSESLTIIFDVTQLSGQSLTIEAAVSSAG 705
             .|     |...|.:..:|:::      ..:...|.|.|....||      ...|.||.|   ||
Human   875 SDGSIECVNEERRLQKQVCNVSYPFFRAKAKVAFRLDFEFSKSIF------LHHLEIELA---AG 930

  Fly   706 MDQNPKDNTMSTTIS-LREYAEIDA----------SGGPIDGHIALKEY-----PYSA--EVNNS 752
            .|.|.:|:|....:: ||.:.:.:|          |...:..:.:|:.|     |:|.  .:.|.
Human   931 SDSNERDSTKEDNVAPLRFHLKYEADVLFTRSSSLSHYEVKPNSSLERYDGIGPPFSCIFRIQNL 995

  Fly   753 YEFKSHGPSIIDELTVYVDVPIAYTVTGSAGIKSIFNISSLQMQATHGSELVPIK--LYDQTNTL 815
            ..|..||      :.:.:.:|||                     ...|:.|:.::  |.|:.||.
Human   996 GLFPIHG------MMMKITIPIA---------------------TRSGNRLLKLRDFLTDEANTS 1033

  Fly   816 ------AKEY---PLEDSSRRANRKRRELQQDQYAIMPDVN--ISDILTKENLPANRTLVLDCLR 869
                  :.||   |:|:..|||               |.:|  .||:::           ::|
Human  1034 CNIWGNSTEYRPTPVEEDLRRA---------------PQLNHSNSDVVS-----------INC-- 1070

  Fly   870 GNWTICVRSQMRVQLKPEQPIDLRISFKVDLNDFVNTFDY--LVIFTNVEMFKEGDSTSIALKRN 932
                       .::|.|.|.|:..:...:.|.. :....|  :.|..|..:.::..|..|..:.:
Human  1071 -----------NIRLVPNQEINFHLLGNLWLRS-LKALKYKSMKIMVNAALQRQFHSPFIFREED 1123

  Fly   933 LKPNVIFNYS---ETPLPIWYIILSLIAGHLLLGAMTYILYKLRFFKRGKKEELKRLLEEHRSET 994
            ....::|..|   :..:|||.|:.|.:.|.|||..:...|:||.||:..::.
Human  1124 PSRQIVFEISKQEDWQVPIWIIVGSTLGGLLLLALLVLALWKLGFFRSARRR------------- 1175

  Fly   995 KEPATD 1000
            :||..|
Human  1176 REPGLD 1181

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	VCBS	302..375	CDD:338792	28/74 (38%)
		Int_alpha	351..403	CDD:214549	25/53 (47%)
		Int_alpha	417..463	CDD:214549	18/45 (40%)
		Integrin_alpha2	451..836	CDD:337057	99/492 (20%)
ITGA11	NP_001004439.1	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	24..85		23/72 (32%)
		Int_alpha	39..>78	CDD:214549	16/44 (36%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	91..151		9/60 (15%)
		vWA_integrins_alpha_subunit	163..341	CDD:238746	17/177 (10%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	355..406		16/52 (31%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	411..461		17/56 (30%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	462..527		22/65 (34%)
		Int_alpha	476..>518	CDD:214549	16/42 (38%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	528..586		23/57 (40%)
		Int_alpha	538..592	CDD:214549	25/53 (47%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	590..650		24/66 (36%)
		Integrin_alpha2	635..1034	CDD:285619	92/463 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142001
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940