DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS5 and pat-2

DIOPT Version :9

Sequence 1:	NP_611808.2	Gene:	ItgaPS5 / 37732	FlyBaseID:	FBgn0034880	Length:	1018	Species:	Drosophila melanogaster
Sequence 2:	NP_498948.1	Gene:	pat-2 / 176240	WormBaseID:	WBGene00003929	Length:	1226	Species:	Caenorhabditis elegans

Alignment Length:	1283	Identity:	282/1283 - (21%)
Similarity:	464/1283 - (36%)	Gaps:	384/1283 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 HLKTRMIQVR---SSYFGYSLVI------RPTSIFVGAPRAQSTLESQGSINETGAVYRCPLASG 89
            ::.|:.:.|.   .:||||||..      .|. :.||||.|:|...:...|...||||.|.:...
Worm    27 NIDTKNVVVHHMAGNYFGYSLDFYHEQKGMPV-LVVGAPEAESNNPNLAGIRRPGAVYACSVNRA 90

  Fly    90 SCSHYVLN------DKLN---------KQFQWLGGSMDGGTKDTDKLLVCAPR--FFVPKNKNYG 137
            :|....::      .|||         |..|:.|.::....|. ||::||||:  :|..|.:...
Worm    91 TCREVHVDKMKGNLKKLNGSHLVPIEEKSHQFFGATVRSNDKH-DKIVVCAPKYTYFYSKFEVIE 154

  Fly   138 QMRGICYWVRDTVADTPPLSDVRTISLIPSQAEEHFM--LELGLSAHV---TDDNSGFLIGAPGV 197
            .: |.|::..:...:....|..:.   .|::...|.:  .:.|.||.|   .:.|..| ||||||
Worm   155 PV-GTCFYAENGFDNAEEFSSCKQ---EPARHGRHRLGYGQCGFSAAVPGKKNQNRVF-IGAPGV 214

  Fly   198 RSWKGSVLVH--RGEDLAAQGSYAVKMLDSWDWVKNHFTYVGYALSSGYFSSNNRTSLLYVTTAP 260
            ..|:|::...  :.:.......|..|..|        ...:||:.::|.|..:....:  |...|
Worm   215 WYWQGAMFSQNIKNQTDRPNTEYGSKEYD--------HDMMGYSTATGDFDGDGIDDI--VAGVP 269

  Fly   261 SS-------VLNTGK-AYIFDVVGEIVRKLHVFHGEQLGEYFGYSVVAEDLNGDGLTDVVVSAPL 317
            ..       ||.|.| ..:.::..|:        ..|.|:|.|.||...|:|.||..|:::..|.
Worm   270 RGNDLHGKLVLYTSKLKMMINLTDEV--------STQHGQYCGGSVAVADVNKDGRDDIIMGCPF 326

  Fly   318 ----NALGDS--------YDVGAIYVFINKGLFKFEKKIIRLPLSSGARFGSSLSKVGDINHDGY 370
                .::.|:        ||||.:.|.:......|.|:|..:......|||.:::..||:|.|||
Worm   327 YTDYGSVKDAKTQERKPQYDVGKVIVMLQTAPGVFGKQIAVVGDDQWGRFGHAVAAAGDLNLDGY 391

  Fly   371 NDLAVGAPFAG---NGAVFIFLGSEHGLRDEPSQRLDAPSREPGPYGAHMFGQGLSRGSDIDGNG 432
            ||:.||||:||   .|||::..||:.|:|:.|:|:::..:...|  ....||..|:...|:||||
Worm   392 NDVIVGAPYAGKNKQGAVYVIHGSKDGVRELPTQKIEGANIGHG--NIKSFGFSLTGNEDVDGNG 454

  Fly   433 FNDLAIGA--PGAEAVYLYRAYPVVKIHATVRSESRAIRPEQETITV------TACYRLET---- 485
            ..|:|:||  .|..||.|.:  |||.:......||..|..|.:...|      .||..:.|
Worm   455 MPDIAVGAWKSGNAAVLLTK--PVVTVTGQTEPESALISVEDKNCDVDGKLGKQACKHINTCFKY 517

  Fly   486 TSKARQMQQQELTFRMTIDE--------LLQR----------VSFAPMRTNEVSFQAQAGL-SGS 531
            ..|.......|...|..:|:        .||:          ...:..|.:..|.:.:..| .|.
Worm   518 EGKGDTPNDLEFDLRFNLDDHSPEPRAYFLQKDVKSDRSIKVAQGSKTRDHPSSIEQRVRLEKGR 582

  Fly   532 CRNFSVGVHYTGGI---FTPIDLELHYELAKKIPHSHEAFCESCAVV---DPLEPKY-ATGTLSF 589
            .:.|......:..:   .:||...::|           .:.||....   |.|||.. .|..|||
Worm   583 QKCFRHRFFASSTMKDKLSPIHWSVNY-----------TYVESKTGKLRGDKLEPAIDTTVPLSF 636

  Fly   590 M------TGCAA-HVCVSDLQLSSKDVNSSFIFGSLE-VLSFSYEITNSGEPAYVAQ--FNV--- 641
            .      ..|.. .:||.||::::......|:.|:.: .:..:..:.|.||.:|..:  |:|
Worm   637 QNKINIANNCGKDDLCVPDLKVTAVADREKFLLGTQDNTMLINVTVQNGGEDSYETKLYFDVPQG 701

  Fly   642 ---------------TSSARLPFAKVP---GNCRVRHEVMLCDLNGGRALARGDSESLTIIFDVT 688
                           ::.|..|.:..|   |..     ...|||  |..|...     .::..|.
Worm   702 FEYGGIESVGGDGSKSAPACSPTSDEPDSDGKW-----TFACDL--GNPLPAN-----KVVSSVV 754

  Fly   689 QLSGQS-------LTIEAAVSSAGMDQ---------------------------NPKDNTMSTTI 719
            :::..|       ::|.|.|:|:..::                           ||:....|.|.
Worm   755 RVTASSDKPPLAPISINAHVNSSNDEEAHTVADNKVTFTIPVDFKNQLSLNGRSNPEQVDFSMTN 819

  Fly   720 SLREYAEIDASGGPIDGHIALKEYPYSAEVNNSYEFKSHGPSIIDELTVYVDVP--------IAY 776
            ..|..|..|...||:..|:              |:..:.|||.:|..|:.:..|        :.|
Worm   820 KTRVDAFDDNEIGPVVSHL--------------YQISNRGPSEVDSATLDIFWPSFSTEGGHLLY 870

  Fly   777 TVT---------GSAGIKSIFNISSLQMQATHGSELVPIK------------------LYDQTNT 814
            .:|         |...:|.:.|::.|.::.|  :|.||.:                  ..|:|.|
Worm   871 IITEPVVNPPNKGRCRVKQLQNVNPLNLRIT--NEHVPTEPPVAKTPNEYSREEDDESYEDETTT 933

  Fly   815 LAKE-------------------YPLEDSSRRANRKRRELQQDQ-----YAIMPD---------- 845
            .::.                   |..::...|.|....:..:|:     |..:||
Worm   934 QSQSTRHQSTQHQTHHQSGPVHVYEKDEEKIRQNTGNWQYVEDKKKKGDYEYIPDDQEYDGDDFE 998

  Fly   846 --------------------------------------VNISDI-----LTKE-------NLPAN 860
                                                  ...||:     |:||       ..|.:
Worm   999 EEDDEDFDRAGSKRVKRNPTPKKKKKGGEHRGEPRSDKARFSDLREAVKLSKEAGGVVDYKGPLS 1063

  Fly   861 RTLVLDCLRGNWTICVRSQMRV-QLKPEQPIDLRISFKVDLNDFVNTFDYLVIFTNVEMFKEGDS 924
            |..| ||   |...|...:..: .||.::.:.:.|..::..|..|:           |....||.
Worm  1064 RASV-DC---NSLRCTHIECDIYDLKEDEFVLVEIFSRLYTNTLVD-----------EKNPGGDI 1113

  Fly   925 TSIALKR------NL--KP----------NVIFNYSETPLPIWYIILSLIAGHLLLGAMTYILYK 971
            :|:||.|      ||  ||          |.|.:.....||.|..:|:::.|..:|..:..:|::
Worm  1114 SSLALARVTSTKYNLPHKPTLITAVSTNMNAIASEEGRDLPWWLYLLAILIGLAILILLILLLWR 1178

  Fly   972 LRFFKRGKKEELKRLLEEHRSETKEPATDCEG---NQEEINVEMHSDL 1016
            ..||||.:.......|...|....:.| |.:.   :|::.|...|..:
Worm  1179 CGFFKRNRPPTEHAELRADRQPNAQYA-DSQSRYTSQDQYNQGRHGQM 1225

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	VCBS	302..375	CDD:338792	26/84 (31%)
		Int_alpha	351..403	CDD:214549	26/54 (48%)
		Int_alpha	417..463	CDD:214549	19/47 (40%)
		Integrin_alpha2	451..836	CDD:337057	96/539 (18%)
pat-2	NP_498948.1	Int_alpha	39..98	CDD:214549	20/59 (34%)
		Int_alpha	299..359	CDD:214549	17/59 (29%)
		Int_alpha	372..427	CDD:214549	26/54 (48%)
		Int_alpha	440..>462	CDD:214549	10/21 (48%)
		Integrin_alpha2	473..920	CDD:285619	90/487 (18%)
		Integrin_alpha	1178..1192	CDD:278771	4/13 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910