DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS5 and Itgam

DIOPT Version :9

Sequence 1:	NP_611808.2	Gene:	ItgaPS5 / 37732	FlyBaseID:	FBgn0034880	Length:	1018	Species:	Drosophila melanogaster
Sequence 2:	NP_001076429.1	Gene:	Itgam / 16409	MGIID:	96607	Length:	1154	Species:	Mus musculus

Alignment Length:	1009	Identity:	228/1009 - (22%)
Similarity:	373/1009 - (36%)	Gaps:	315/1009 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 DTVADTP------PLSDVRTISLIPSQAE-----------------EHFMLELGLSAHVTDDNSG 189
            ||:|..|      .:.:...::.|.:|.:                 ||.|.:.|.||.:|  ::|
Mouse   301 DTIASKPAGEHVFQVDNFEALNTIQNQLQEKIFAIEGTQTGSTSSFEHEMSQEGFSASIT--SNG 363

  Fly   190 FLIGAPGVRSWKGSVLVHRGEDLAAQGSYAVKMLDSWDWVKNHFTYVGYALSSGYFSSNNRTSLL 254
            .|:|:.|...|.|...::..:|...  ......:||    ..:..|:|||  |.....|...||
Mouse   364 PLLGSVGSFDWAGGAFLYTSKDKVT--FINTTRVDS----DMNDAYLGYA--SAVILRNRVQSL- 419

  Fly   255 YVTTAPSSVLNTGKAYIFDVVGEIVRKLHVF---------HGEQLGEYFGYSVVAEDLNGDGLTD 310
             |..||.          :..:|.:|.....|         .|.|:|.|||.|:.:.|::.||.|:
Mouse   420 -VLGAPR----------YQHIGLVVMFRENFGTWEPHTSIKGSQIGSYFGASLCSVDMDADGNTN 473

  Fly   311 VVVSAPLNALGDSYDVGAIYVFINKGLFKFEK----KIIRLPLSSG------------------- 352
            :::            :||.:.        :||    ::...||..|
Mouse   474 LIL------------IGAPHY--------YEKTRGGQVSVCPLPRGQRARWQCEALLHGDQGHPW 518

  Fly   353 ARFGSSLSKVGDINHDGYNDLAVGAP--FAGNGAVFIFLG-SEHGLRDEPSQRLDAPSREPGPYG 414
            .|||::|:.:||:|.|...|:|:|||  ....|||:||.| |...|....|||:......|   |
Mouse   519 GRFGAALTVLGDVNGDKLTDVAIGAPGEQENQGAVYIFYGASIASLSASHSQRIIGAHFSP---G 580

  Fly   415 AHMFGQGLSRGSDIDGNGFNDLAIGAPGAEAVYLYRAYPVVKIHATV----RSESRAIRPEQETI 475
            ...|||.||.|.|:..:|..|||:||.|  .:.|.||.||:::.||:    :..:|::...||.:
Mouse   581 LQYFGQSLSGGKDLTMDGLMDLAVGAQG--HLLLLRAQPVLRLEATMEFSPKKVARSVFACQEQV 643

  Fly   476 -------TVTACYRLETTSKARQMQ---QQELTFRMTIDELLQRV-SFAPMRTNEVSFQAQA-GL 528
                   .|..|.|:...:|.|..:   |..:|:.:.:|....|: :|.....|....:.|. ||
Mouse   644 LKNKDAGEVRVCLRVRKNTKDRLREGDIQSTVTYDLALDPGRSRIRAFFDETKNNTRRRTQVFGL 708

  Fly   529 SGSCRNFSVGV-HYTGGIFTPIDLELHYELAKKIPHSHEAFCESCAVVDPLE------------- 579
            ...|....:.: .......:||.|.|:|.|                |.:||.
Mouse   709 MQKCETLKLILPDCVDDSVSPIILRLNYTL----------------VGEPLRSFGNLRPVLAMDA 757

  Fly   580 PKYATGTLSFMTGCA-AHVCVSDLQLSSKDVN-SSFIFGSLEVLSFSYEITNSGEPAYVAQFNV- 641
            .::.|....|...|. ..:|..||.::...:. .:.:.|..:..:.|..:.|.||.:|..|..|
Mouse   758 QRFFTAMFPFEKNCGNDSICQDDLSITMSAMGLDTLVVGGPQDFNMSVTLRNDGEDSYGTQVTVY 822

  Fly   642 ---------TSSARLPFAKVPGNCRVRHEVMLCDLNG---------GRALARGDSE-SLTIIFDV 687
                     .|:::.|..|.|...:........:.:|         ...:...:|| :..:.|||
Mouse   823 YPSGLSYRKDSASQNPLTKKPWFVKPAESSSSSEGHGALKSTTWNINHPIFPANSEVTFNVTFDV 887

  Fly   688 TQLS--GQSLTIEAAVSSAGMDQNPKDNTMSTTISLREYAEIDASGGPIDGHI---------ALK 741
            ...:  |..|.::|.|:|        :|.||.|...:...|:     |:...|         :::
Mouse   888 DSHASFGNKLLLKAIVAS--------ENNMSRTHKTKFQLEL-----PVKYAIYMIVTSDESSIR 939

  Fly   742 EYPYSAE------VNNSYEFKSHG------------PSIIDELTVYVDVPIAYTVTGSAGIKSIF 788
            ...::|.      :.:.|:|.:.|            |..|:.:||: |.|           :.||
Mouse   940 YLNFTASEMTSKVIQHQYQFNNLGQRSLPVSVVFWIPVQINNVTVW-DHP-----------QVIF 992

  Fly   789 --NISSLQMQATHGSELVPIKLYDQTNTLAKEYPLEDSSRRANRKRRELQQDQYAIMPDVNISDI 851
              |:||    |.|..:..|                                      |..|..|.
Mouse   993 SQNLSS----ACHTEQKSP--------------------------------------PHSNFRDQ 1015

  Fly   852 LTKENLPANRTLVLDCLRGNWTICVRSQMRVQLKPEQPIDLRISFKVDLNDFVNTFD-------- 908
            |       .||.||:|   :..:|.|.|..:.....|.| ..::.|.:|     :||
Mouse  1016 L-------ERTPVLNC---SVAVCKRIQCDLPSFNTQEI-FNVTLKGNL-----SFDWYIKTSHG 1064

  Fly   909 YLVIFTNVE-MFKE-------GDSTSIALKRNLK--PNVIFNYSETPLPIWYIILSLIAGHLLLG 963
            :|::.::.| :|.:       |..:.:..|...|  |..:.|    |:|:  |:.|.|.|.:||.
Mouse  1065 HLLLVSSTEILFNDSAFALLPGQESYVRSKTETKVEPYEVHN----PVPL--IVGSSIGGLVLLA 1123

  Fly   964 AMTYILYKLRFFKRGKKEELKRLLEEHRSETKEP 997
            .:|..||||.||||    :.|.::.|...:...|
Mouse  1124 LITAGLYKLGFFKR----QYKDMMNEAAPQDAPP 1153

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	VCBS	302..375	CDD:338792	20/95 (21%)
		Int_alpha	351..403	CDD:214549	24/73 (33%)
		Int_alpha	417..463	CDD:214549	21/49 (43%)
		Integrin_alpha2	451..836	CDD:337057	86/467 (18%)
Itgam	NP_001076429.1	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	18..75
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	76..135
		vWA_integrins_alpha_subunit	149..324	CDD:238746	4/22 (18%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	339..390		14/54 (26%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	391..442		16/68 (24%)
		Int_alpha	453..>495	CDD:214549	13/61 (21%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	507..565		20/57 (35%)
		Int_alpha	517..>558	CDD:214549	18/40 (45%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	570..630		25/64 (39%)
		Int_alpha	582..>620	CDD:214549	19/39 (49%)
		Integrin_alpha2	615..1034	CDD:285619	97/511 (19%)
		Integrin_alpha	1131..1143	CDD:278771	7/15 (47%)
		GFFKR motif	1133..1137		2/3 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832067
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.940