DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS5 and Itga3

DIOPT Version :9

Sequence 1:	NP_611808.2	Gene:	ItgaPS5 / 37732	FlyBaseID:	FBgn0034880	Length:	1018	Species:	Drosophila melanogaster
Sequence 2:	NP_001293091.1	Gene:	Itga3 / 16400	MGIID:	96602	Length:	1068	Species:	Mus musculus

Alignment Length:	1160	Identity:	286/1160 - (24%)
Similarity:	450/1160 - (38%)	Gaps:	310/1160 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 PLPNRVIDAPK--------------------HLKTRMIQVR-----SSYFGYSLVI-RPTS---- 57
            |.|.||..||.                    :|.||.:.|:     .|.||||:.: |.|.
Mouse     3 PGPCRVPRAPGWLLRALALMVAACGRVAFAFNLDTRFLVVKEAVNPGSLFGYSVALHRQTERQQR 67

  Fly    58 --IFVGAPRAQSTLESQGSINETGAVYRCPLAS--GSC-----------SHYVLNDKLNKQFQWL 107
              :..||||..:.  .....|.|||||.|||.:  ..|           .|:::.|      .||
Mouse    68 YLLLAGAPRDLAV--GDDYTNRTGAVYLCPLTAHKDDCERMDISEKSDPDHHIIED------MWL 124

  Fly   108 GGSMDGGTKDTDKLLVCAPRF---FVPKNKNYGQMRGICYWVRDTVADTPPLSDVRTI--SLIPS 167
            |.:: .......::||||.|:   .....::..:|.|.|| ||.......|..|.:|.  .:..|
Mouse   125 GVTV-ASQGPAGRVLVCAHRYTKVLWSGLEDQRRMVGKCY-VRGNDLQLDPGDDWQTYHNEMCNS 187

  Fly   168 QAE--EHFMLELGLSAHVTDDNSGFLIGAPGVRSWKGSVLVHRGEDLAAQGSYAVKMLDSWDWVK 230
            ..:  :..|.:||.|...|.:...|  ||||..:|||:             ||.::..| ||..:
Mouse   188 NTDYLQTGMCQLGTSGGFTQNTVYF--GAPGAYNWKGN-------------SYMIQRKD-WDLSE 236

  Fly   231 NHF--------TYVGYALSSGYFSSNNRTSLLYVTTAPSSVLNTGKAYIF--DVVGEIVRKLHVF 285
            ..:        .|:||.:..|. :..:.|.::.|.|......:.|..::.  :..|::.|| .|.
Mouse   237 YSYRGSEEQGNLYIGYTVQVGN-AILHPTDIITVVTGAPRHQHMGAVFLLKQESGGDLQRK-QVL 299

  Fly   286 HGEQLGEYFGYSVVAEDLNGDGLTDVVVSAPLNALGDSYDVGAIYVFINKGLFKF-EKKIIRLPL 349
            .|.|:|.|||.::...|||.||..|::|.||..........||:|||:|:....| ::..:.|..
Mouse   300 KGTQVGAYFGSAIALADLNNDGWQDLLVGAPYYFERKEEVGGAVYVFMNQAGASFPDQPSLLLHG 364

  Fly   350 SSGARFGSSLSKVGDINHDGYNDLAVGAPFAGNGAVFIFLGSEHGLRDEPSQ-----RLDAPSRE 409
            .|.:.||.|::.:||||.||:.|:||||||.|.|.|:|:..|..||..:|.|     :|..|
Mouse   365 PSRSAFGISIASIGDINQDGFQDIAVGAPFEGLGKVYIYHSSSGGLLRQPQQIIHGEKLGLP--- 426

  Fly   410 PGPYGAHMFGQGLSRGSDIDGNGFNDLAIGAPGAEAVYLYRAYPVVKI-HATVRSESRAIRPEQE 473
                |...||..||...|:|.|.:.||.:|:. ::.:.|.||.||:.| |.|:.:....:.|  .
Mouse   427 ----GLATFGYSLSGKMDVDENLYPDLLVGSL-SDHIVLLRARPVINILHRTLVARPAVLDP--A 484

  Fly   474 TITVTACYRLE-----TTSKARQMQQQELTFRMTI----DELLQRVSFAPMRTNEVSFQAQAGLS 529
            ..|.|:|.::|     ..|......::.:|...|:    |....|:.||
Mouse   485 LCTATSCVQVELCFAYNQSAGNPNYRRNITLAYTLEADRDRRPPRLRFA---------------- 533

  Fly   530 GSCRNFSVGVHYTGGIFT----------------------PIDLELHYELAKKIP-------HSH 565
               |:.|...|   |.|:                      ||.:.::|.|..::|       .|.
Mouse   534 ---RSQSSVFH---GFFSMPETHCQTLELLLMDNVRDKLRPIVIAMNYSLPLRMPDRLKLGLRSL 592

  Fly   566 EAFCESCAVVDPLEPKYATGTLSFMTGCAA-HVCVSDLQLSSKDVNSSFIFGSLEVLS------- 622
            :|:    .|::..:.......:.|...|.. :.|.|:||:     .::|:...|:.||
Mouse   593 DAY----PVLNQAQAMENHTEVHFQKECGPDNKCDSNLQM-----RAAFLSEQLQPLSRLQYSRD 648

  Fly   623 -----FSYEITNS------GEPAYVA--QFNVTSSARLPFAKVPGNCRVRHEVMLCDLNGGRALA 674
                 .|..:|||      ||.|:.|  ...|.|:..|...:..|.|:..:|.:||:|  |....
Mouse   649 TKKLFLSINVTNSPSSQRAGEDAHEALLTLEVPSALLLSSVRPSGTCQANNETILCEL--GNPFK 711

  Fly   675 RGDSESLTIIFDV--TQLSGQSLTIEAAVSSAGMDQNPK--------DNTMSTTISLREYAEIDA 729
            |.....|.|.|:|  ..|..:.|.:...:|::....|.:        |.|:..::||..:.....
Mouse   712 RNQRMELLIAFEVIGVTLHTRDLPVLLQLSTSSHQDNLQPVLLTLQVDYTLQASLSLMNHRLQSF 776

  Fly   730 SGGPIDGHIALKEYPYSAEVNNS---YEFK----SHGPSIIDELTVYVDVPIAYTVTGSAGIKSI 787
            .||.:.|..|:|    :||...|   |||:    ..|.:.:..|.:.::.|  |.||....:
Mouse   777 FGGTVMGEAAMK----TAEDVGSPLKYEFQVSPVGDGLAALGTLVLGLEWP--YEVTNGKWL--- 832

  Fly   788 FNISSLQMQATHGSELVPIKLYDQTNTLAKEYPLEDSSRRAN-----------------RKRREL 835
                           |.|.::...:|   ..:|.:.|....|                 |:||:|
Mouse   833 ---------------LYPTEITIHSN---GSWPCQPSGNLVNPLNLTLSDPGVTPLSPQRRRRQL 879

  Fly   836 QQDQYAIMPDVNISDILTKENLPANRTLVLDCLRGN----WTIC----------VRSQMRVQLKP 886
            ........|.|.::  ..|:   |....||.|..|.    |..|          |..:.||
Mouse   880 DPGGDQSSPPVTLA--AAKK---AKSETVLTCSNGRARCVWLECPLPDTSNITNVTVKARV---- 935

  Fly   887 EQPIDLRISFKVDLNDF----VNTFDYLVIFTNVEMFKEGDST---SIALKRNLKPNVIFNYSET 944
                 ...:|..|..||    |:.:..|.:.|::......:.|   |:.:...|       ..|.
Mouse   936 -----WNSTFIEDYKDFDRVRVDGWATLFLRTSIPTINMENKTTWFSVDIDSEL-------VEEL 988

  Fly   945 P--LPIWYIILSLIAGHLLLGAMTYILYKLRFFKRGK------KEELKRLLEEHR 991
            |  :.:|.:::::.||.||||.:..:|:|..|||..:      |....|:.||.|
Mouse   989 PAEIELWLVLVAVGAGLLLLGLIILLLWKCDFFKPTRYYRIMPKYHAVRIREEDR 1043

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	VCBS	302..375	CDD:338792	28/73 (38%)
		Int_alpha	351..403	CDD:214549	26/56 (46%)
		Int_alpha	417..463	CDD:214549	18/46 (39%)
		Integrin_alpha2	451..836	CDD:337057	98/478 (21%)
Itga3	NP_001293091.1	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	38..103		22/66 (33%)
		Int_alpha	48..108	CDD:214549	21/61 (34%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	110..171		16/68 (24%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	185..235		19/65 (29%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	236..293		9/57 (16%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	294..355		24/61 (39%)
		Int_alpha	305..353	CDD:214549	19/47 (40%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	357..412		25/54 (46%)
		Int_alpha	368..418	CDD:214549	25/49 (51%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	416..478		22/69 (32%)
		Integrin_alpha2	463..918	CDD:369878	108/521 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	865..890		5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832060
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840