Protein Alignment ItgaPS5 and Itga1

DIOPT Version :10

• Sequence 1: NP_611808.2
• Gene: ItgaPS5 / 37732
• FlyBaseID: FBgn0034880
• Length: 1018
• Species: Drosophila melanogaster
• Sequence 2: NP_001028400.2
• Gene: Itga1 / 109700
• MGIID: 96599
• Length: 1179
• Species: Mus musculus
• Alignment Length: 1043
• Identity: 238/1043 - (22%)
• Similarity: 418/1043 - (40%)
• Gaps: 226/1043 - (21%)

  Fly    56 TSIFVGAPRAQSTLESQGSINETGAVYRCPLASGSCSHY----VLNDKLNKQFQWLG----GSMD 112
            |::.:...|.::..|::|:......|........|..:|    |:.|..::..|...    |..:
Mouse   250 TALGIDTARKEAFTEARGARRGVKKVMVIVTDGESHDNYRLKQVIQDCEDENIQRFSIAILGHYN 314

  Fly   113 GGTKDTDKLLVCAPRFFVPKNKNYGQMRGICYWVRDTVADTPP------LSD-VRTISLIPSQAE 170
            .|...|:|        ||.:.|              ::|..|.      :|| :..::::.:..|
Mouse   315 RGNLSTEK--------FVEEIK--------------SIASEPTEKHFFNVSDELALVTIVKALGE 357

  Fly   171 EHFMLE----------------LGLSAHVTDDNSGFLIGAPGVRSWKGSVLVHRGEDLAAQGSYA 219
            ..|.||                .|.|||.:.|  ..::||.|...|.|:|::.:...:....:..
Mouse   358 RIFALEATADQSAASFEMEMSQTGFSAHYSQD--WVMLGAVGAYDWNGTVVMQKANQIVIPHNTT 420

  Fly   220 -----VKMLDSWDWVKNHFTYVGYALSSGYFSSNNRTSLLYVTTAPSSVLNTGKAYIFDVVGEIV 279
                 .||.:..      .:|:||.::|.....:    :||:...| ...:||:..|:.:....|
Mouse   421 FQTEPTKMNEPL------ASYLGYTVNSATIPGD----VLYIAGQP-RYNHTGQVVIYKMEDGDV 474

  Fly   280 RKLHVFHGEQLGEYFGYSVVAEDLNGDGLTD-VVVSAPLNALGDSYDVGAIYVF-INKGLFKFEK 342
            ..|....|||:|.|||..:...|::.|..|| ::|.||:....:..:.|.:||: :|:..|:::.
Mouse   475 NILQTLSGEQIGSYFGSVLTTIDIDKDSYTDLLLVGAPMYMGTEKEEQGKVYVYAVNQTRFEYQM 539

  Fly   343 KI--IRLPLSS----------------GARFGSSLSKVGDINHDGYNDLAVGAPFAGN--GAVFI 387
            .:  |:....|                |||||::::.|.|:|.||:||:.:|||...:  |||:|
Mouse   540 SLEPIKQTCCSSLKDNSCTKENKNEPCGARFGTAVAAVKDLNVDGFNDVVIGAPLEDDHAGAVYI 604

  Fly   388 FLGSEHGLRDEPSQRLDAPSREPGPYGAHMFGQGLSRGSDIDGNGFNDLAIGAPGAEAVYLYRAY 452
            :.||...:|.|.:||:  ||...|. ....|||.:....|::|:|..|:.||..|..|::..|..
Mouse   605 YHGSGKTIRKEYAQRI--PSGGDGK-TLKFFGQSIHGEMDLNGDGLTDVTIGGLGGAALFWARDV 666

  Fly   453 PVVKIHAT-----VRSESRAIRPE-QETITV--TACYRLETTSKARQMQQQELTFRMTIDELLQ- 508
            .|||:...     |..:.:..|.| :||:.:  |.|:.::..||...:.:.:|.:|:|:|.|.|
Mouse   667 AVVKVTMNFEPNKVNIQKKNCRVEGKETVCINATMCFHVKLKSKEDSVYEADLQYRVTLDSLRQI 731

  Fly   509 -RVSFAPMRTNEVSFQAQAGLSGSCRN--FSVGVH-YTGGIFTPIDLELHYELAKKIPHSHEAFC 569
             |..|:..:...:........|...|:  :.:..| :...:...:|..|             ...
Mouse   732 SRSFFSGTQERRIQRNLTVRESECIRHSFYMLDKHDFQDSVRVTLDFNL-------------TDP 783

  Fly   570 ESCAVVDPLEPKYATGTLSFMTGCA-AHVCVSDLQL--SSKDVNSSFIFGSLEVLSFSYEITNSG 631
            |:..|:|...|....|.:.|...|. ...|||||.|  |:.:.|...:....:..:.|..:.|.|
Mouse   784 ENGPVLDDALPNSVHGHIPFAKDCGNKERCVSDLTLDVSTTEKNLLIVRSQNDKFNVSLTVKNKG 848

  Fly   632 EPAYVAQFNVTSSARLPFAKVPG------------NCRVRHEVMLCDLNGGRALARGDSESLTII 684
            :.||..:..|..|..|.|:.:..            .|||          |...|..||..:..||
Mouse   849 DSAYNTRTVVQYSPNLIFSGIEEIQKDSCESNQNITCRV----------GYPFLRTGDVVNFKII 903

  Fly   685 --FDVTQLSGQSLTIEAAVSSAGMDQNP----KDNTMSTTISLREYAEIDASGGPIDGHIALKEY 743
              |:.:.||..::...:|.|.:   :.|    .||.::.:|             |:...:.|:.|
Mouse   904 FQFNTSHLSENAIIHLSATSDS---EEPLESLYDNEVNISI-------------PVKYEVGLQFY 952

  Fly   744 PYSAEVNNSYEFKSHGPSII-------DELTVYVDVPIAYTVTGSAGIKSIFNISSLQMQATHGS 801
            ..::|.:.|.......|.:|       ||:.|:      ||:..    :..|.:..|::..:.
Mouse   953 SSASEHHISVAANETVPELINSTKDIGDEINVF------YTIRK----RGHFPMPELRLAISF-- 1005

  Fly   802 ELVPIKLYDQTNTLAKEYPL-----EDSSRRANRKRRELQQDQYAI----MPDVNISDILTKENL 857
                      .|..:..||:     ..||...|.:.|.| :|...|    ...::.|::|
Mouse  1006 ----------PNLTSDGYPVLYPTGWSSSDNVNCRPRSL-EDPLGINSGKKMTISKSEVL----- 1054

  Fly   858 PANRTLVLDCLRGNWTICVRSQMRVQLKPEQPIDLRISFKVDLNDFVNT-FDYLVIFTNVEMFKE 921
              .|..:.||     :.|..:.:...|.|.....:.:|..:....|:.. |..|.:....|:..|
Mouse  1055 --KRGTIQDC-----STCKIATITCHLLPSDVSQVNVSLILWKPTFIKAHFSSLNLTIRGELQSE 1112

  Fly   922 GDSTSIALKRNLKPNVIFNYSETPL----PIWYIILSLIAGHLLLGAMTYILYKLRFFKRGKKEE 982
            ..|.::: ..|.|..:....|:..|    |:|.|:||..||.|||..:...|:|:.||||..|::
Mouse  1113 NSSLTLS-SSNRKRELAIQISKDGLPGRVPLWVILLSAFAGLLLLMLLILALWKIGFFKRPLKKK 1176

  Fly   983 LKR 985
            :::
Mouse  1177 MEK 1179

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	FG-GAP	294..332	CDD:460357	11/38 (29%)
		Int_alpha	351..403	CDD:214549	25/69 (36%)
		Int_alpha	417..463	CDD:214549	16/50 (32%)
		Integrin_alpha2	453..837	CDD:462478	89/429 (21%)
Itga1	NP_001028400.2	FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	30..91
		FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	101..160
		vWA_integrins_alpha_subunit	171..351	CDD:238746	21/122 (17%)
		FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	365..417		11/53 (21%)
		FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	422..474		12/62 (19%)
		FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	475..537		20/61 (33%)
		Int_alpha	485..>528	CDD:214549	13/42 (31%)
		FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	556..614		21/57 (37%)
		Int_alpha	567..620	CDD:214549	24/52 (46%)
		FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	618..678		20/62 (32%)
		Integrin_alpha2	664..1044	CDD:462478	92/441 (21%)
		GFFKR motif	1167..1171		2/3 (67%)