DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS5 and Itga9

DIOPT Version :9

Sequence 1:	NP_611808.2	Gene:	ItgaPS5 / 37732	FlyBaseID:	FBgn0034880	Length:	1018	Species:	Drosophila melanogaster
Sequence 2:	NP_598482.2	Gene:	Itga9 / 104099	MGIID:	104756	Length:	1036	Species:	Mus musculus

Alignment Length:	1125	Identity:	281/1125 - (24%)
Similarity:	473/1125 - (42%)	Gaps:	243/1125 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RLLFLIFLALKYQSNAMNFSPLPNRVIDAPKHLKTRMIQVRSSYFGYSLV----IRPTSIFVGAP 63
            |.|.|..:|....:.|.|        :||.:  ..|......|:|||:::    .....:.||||
Mouse    15 RALLLALVAAGVPAGAYN--------LDAQR--PVRFQGPSGSFFGYAVLEHFHDNTRWVLVGAP 69

  Fly    64 RAQSTLESQGSINETGAVYRC-------------PLASG-----SCSHYVLNDKLNKQFQWLGGS 110
            :|.|...:  |:...|||::|             .:|.|     .|......|   :..:|:|.|
Mouse    70 KADSKYST--SVKSPGAVFKCRVHTNPDRRCTELDMARGRTRGAPCGKTCRGD---RDDEWMGVS 129

  Fly   111 MDGGTKDTDKLLVCAPRFFVPKNKNYGQ----MRGICYWVRDTVADTPPLSDVRTISLIP----- 166
            :....:...::|.||.|:   ||..|..    ..|.||.:       |.....:...|||
Mouse   130 LARQPRADGRVLACAHRW---KNIYYEADHILPHGFCYLI-------PSNLQAKGKVLIPCYEEY 184

  Fly   167 --SQAEEHFMLELGLSAHVTDDNSGFLIGAPGVRSWKGSVLVHRGEDLAAQGSYAVKMLDSWDWV 229
              ...|||...:.|::...|::.  .::||||...|.|::.|....|    .:| .|:.|  :.:
Mouse   185 KKKYGEEHGSCQAGIAGFFTEEL--VVMGAPGSFYWAGTLKVLNLTD----NTY-FKLND--EAI 240

  Fly   230 KN-HFTYVGYALSSGYFSSNNRTSLLYVTTAPSSVLNTGKAYIFDV---VGEIVRKLHVFHGEQL 290
            .| .:||:|||:::|:||..:.|.:  |..||... ..||.|||..   .|.:: |:....|:::
Mouse   241 MNRRYTYLGYAVTAGHFSHPSITDV--VGGAPQDE-GIGKVYIFRADRRSGTLI-KIFQASGKKM 301

  Fly   291 GEYFGYSVVAEDLNGDGLTDVVVSAPLNALGDSYDVGAIYVFINKGLFKFEKKI-IRLPLSSGAR 354
            |.|||.|:.|.|||.|||:|::|.||:  ..:..|.|.:.|::|:|....|::: :....:..|.
Mouse   302 GSYFGSSLCAVDLNMDGLSDLLVGAPM--FSEIRDEGQVTVYLNQGHGALEEQLTLTGDAAYNAH 364

  Fly   355 FGSSLSKVGDINHDGYNDLAVGAP----FAGNGAVFIFLGSEHGLRDEPSQRLDAPSREPGPYGA 415
            ||.|::.:|||:.||:.|:|||||    ||  |||:|:.|..:|:..:.|.:|......|   ..
Mouse   365 FGESIANLGDIDDDGFPDVAVGAPKEEDFA--GAVYIYHGDANGIVPKYSMKLSGRRLNP---TL 424

  Fly   416 HMFGQGLSRGSDIDGNGFNDLAIGAPGAEAVYLYRAYPVVKIHATVRSESRAIRPEQETIT---- 476
            .||||.:|.|.|:||||:.|:.|||..:::|.|.||.||:.:..::      ..|....||
Mouse   425 RMFGQSISGGIDMDGNGYPDVTIGAFLSDSVVLLRARPVITVDVSI------FLPGSINITAPQC 483

  Fly   477 -----------VTACYRLETTSKARQMQQQELTFRMTIDEL------LQRVSFAPMRTNEVSFQA 524
                       ||.|:|....:...::   .|.:.:|.|..      |.||.|       |.|..
Mouse   484 HDGQQPVNCLNVTVCFRFHGKNVPGEI---GLNYNLTADVAQKEKGQLPRVYF-------VLFGE 538

  Fly   525 QAGLSGSCRNFS----VGVHYTG-------GIFTPIDLELHYELAKKIPHSHEAFCESCAVV--- 575
            .||........|    |..||..       .:.:||..|..|.|.:.:....:........|
Mouse   539 TAGQVSERLQLSHMDEVCHHYVAHVKRRVQDVISPIVFEAAYSLDEHVMGEEDRELPDLTPVLRW 603

  Fly   576 ---DPLEPKYATGTLSFMTGCAAHVCVSDLQLSSKDVNSS-------FIFGSLEVLSFSYEITNS 630
               ..:..|..|   .|...|.:..|.:||||..|.:.||       ...|:::.:|.:..|:|.
Mouse   604 KKGQRISQKNQT---VFERNCQSEDCAADLQLRGKLLLSSVDEKTPHLALGAVKNISLNISISNL 665

  Fly   631 GEPAYVAQFNVTSSARLPFAKVPGNCRVRHEV-MLCDL--------NGGRALARGDSE-SLTIIF 685
            |:.||.|..:...|..|.|.    |...:.|: :.|:|        :.|....|..|: ..::||
Mouse   666 GDDAYDANVSFNVSRELFFI----NMWQKEEMGISCELLESDFLKCSVGFPFMRSKSKYEFSVIF 726

  Fly   686 DVTQLSGQS--LTIEAAVSSAGMDQNP--KDNTMSTTISLREYAEIDASGGPIDGHIALKEYPYS 746
            |.:.|||:.  |:......|..::::.  .|||::.|:.|  ..|:|.|   |.|.::...:.|.
Mouse   727 DTSHLSGEEEILSFIVTAQSGNLERSEALHDNTLTLTVPL--VHEVDTS---ITGIVSPTSFVYG 786

  Fly   747 AE------------------VNNSYEFKSHGPSIIDELTVYVDVPIAYTVTGSAGIKSIFNISSL 793
            ..                  ||.:.:..:.|||.:...:|.:..|...    |.|...:|.:..:
Mouse   787 ESVDASNFIQLDDQECHFQPVNITLQVYNMGPSTLPGSSVSISFPSRL----SPGGAEMFQVQDM 847

  Fly   794 QMQATHGSELVPIKLYDQTNTLAKEYPLEDSS---------RRANRKRRELQQ-DQYAIMPDVNI 848
            .:....|:..:      |.|......|.|..:         .::.||..:.:: ..:.:....|:
Mouse   848 VVSQEKGNCSL------QRNPTPCIIPQEQENIFHTIFAFFSKSGRKVLDCEKPGSFCLTLHCNL 906

  Fly   849 SDILTKENLPANRTLVL--DCLRGNWTICVRSQMRVQLKPEQPIDLRISFKVDLNDFVNTFDYLV 911
            |.:..:|:...|..::|  :.|:.:.:..::...|.::|.|..  ||:   |::.: .|..:.||
Mouse   907 SALPKEESRTINLYMLLNTEILKKDSSSVIQFMARAKVKVEPA--LRV---VEIAN-GNPEETLV 965

  Fly   912 IFTNVEMFKEGDSTSIALKRNLKPNVIFNYSETPLPIWYIILSLIAGHLLLGAMTYILYKLRFFK 976
            :|..:              .||:|.   .|    :..|.|.:||:.|.|:...:..:|:|:.||:
Mouse   966 VFEAL--------------HNLEPR---GY----VVGWIIAISLLVGILIFLLLAVLLWKMGFFR 1009

  Fly   977 RGKKEELKRLLEEHRSETKE 996
            |..||.::  .|::|.|.::
Mouse  1010 RRYKEIIE--AEKNRKENED 1027

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	VCBS	302..375	CDD:338792	26/73 (36%)
		Int_alpha	351..403	CDD:214549	24/55 (44%)
		Int_alpha	417..463	CDD:214549	21/45 (47%)
		Integrin_alpha2	451..836	CDD:337057	97/470 (21%)
Itga9	NP_598482.2	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	36..97		16/64 (25%)
		Int_alpha	45..102	CDD:214549	15/58 (26%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	109..175		16/78 (21%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	183..233		14/56 (25%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	234..290		21/60 (35%)
		Int_alpha	245..295	CDD:214549	19/53 (36%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	291..350		23/61 (38%)
		Int_alpha	301..348	CDD:214549	21/48 (44%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	352..409		23/58 (40%)
		Int_alpha	362..415	CDD:214549	24/54 (44%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	412..475		25/71 (35%)
		Int_alpha	426..>467	CDD:214549	21/40 (53%)
		Integrin_alpha2	460..904	CDD:285619	97/481 (20%)
		GFFKR motif. /evidence=ECO:0000250\|UniProtKB:Q13797	1006..1010		2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832075
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D105280at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.950