DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS5 and itgam.1

DIOPT Version :9

Sequence 1:	NP_611808.2	Gene:	ItgaPS5 / 37732	FlyBaseID:	FBgn0034880	Length:	1018	Species:	Drosophila melanogaster
Sequence 2:	XP_005156064.1	Gene:	itgam.1 / 101882585	ZFINID:	ZDB-GENE-110411-175	Length:	1136	Species:	Danio rerio

Alignment Length:	1262	Identity:	263/1262 - (20%)
Similarity:	428/1262 - (33%)	Gaps:	453/1262 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 SPLPNRVIDAPKHLKTRMIQVRSSYFGYSLVIRP-TSIFVGAPRAQSTLESQGSIN--ETGAVYR 83
            :||.|.|.                 |||.::... |.:.|..|..|        ||  |.|.:|.
Zfish    34 APLTNNVA-----------------FGYKVIQEDMTRLTVSDPLIQ--------INRDERGQIYS 73

  Fly    84 CPLASGSCSHY-----VLNDKLNKQFQWLGGSMDGGTKD--TDKLLVCAPRFFVPKN-KNYGQMR 140
            |.:..|:||..     |.::.:|..   ||.||   .||  :.||:||.|.  :||| .......
Zfish    74 CDVNRGTCSSLNIYGRVPSEAVNMS---LGLSM---VKDPGSSKLVVCGPT--IPKNCPGVSTYN 130

  Fly   141 GICYWVRDTVADTPPL-SDVRTISLIPSQAEEHFMLELGLSAHVTDDNS---------------- 188
            |:|:......:.|.|: |.:|...  .||.:..|:|:...|....|.|.
Zfish   131 GMCFVNEHRRSFTGPIPSSLRECP--KSQIDIAFLLDGSGSVDPVDFNKMKAFVVEMIKSFIDRD 193

  Fly   189 --------------------------------------GFLIGAPGVRSWKGSVLVHRGEDLAAQ 215
                                                  |:...|..:|....|:.|..|.  |.|
Zfish   194 TQFAIAQFSTECVIHYKFQQVKNPAWWQRAVNGIQQTHGWTFTATAIRLLVESLFVSSGG--ARQ 256

  Fly   216 GS-------------------------------YAV----------------------------K 221
            .:                               ||:                            |
Zfish   257 SASKILVVITDGESNDKFLTEAVQQAQEKSITRYAIGVGNAFNKYSARNELTVIASIPTDKHVFK 321

  Fly   222 MLD-----------------------SWDWVKNHFTYVGY--ALSS----------------GY- 244
            :.|                       |.|..:..|...|:  ||:|                ||
Zfish   322 VTDFDALESIREILKENIIAIEGTQTSGDSSRMEFAQDGFSAALTSDTDLIMTAVGAFQWKGGYQ 386

  Fly   245 -FSSNNRTSL----------LYVTTAPSSVLNTGKAYIFDVVGEIVRKLHVFHG----------- 287
             |..|::||:          |..:.|.::|.||..|    |:|   ...|...|
Zfish   387 LFKLNDQTSVFQAGSEHNSYLGYSLAIATVYNTKYA----VMG---APRHKHEGLVTVTRIDRMS 444

  Fly   288 ---------EQLGEYFGYSVVAEDLNGDGLTD-VVVSAPLNALGDSYDVGAIYVFINKGLFKFEK 342
                     .|:|.|||..|...|||.|..|| ::||||.....:......:|.:..:..|.|..
Zfish   445 DQIQLDPPKTQIGSYFGAEVCVVDLNSDSNTDLLLVSAPTYTESEREGKVFVYSYTRRPFFSFSD 509

  Fly   343 KIIRLPLSSGARFGSSLSKVGDINHDGYNDLAVGAPFA--GNGAVFIFLGSEHGLRDEPSQRLDA 405
            .::........||||||:...|:|.||:.|:.||||..  |.|:::||.|.:.|:....|||:..
Zfish   510 VVLVGMAGQRGRFGSSLASPADLNGDGFKDVLVGAPLEEDGKGSIYIFNGRDGGIISSYSQRIAG 574

  Fly   406 PSREPGPYGAHMFGQGLSRGS-DIDGNGFNDLAIGAPGAEAVYLYRAYPVVKIHATVRSESRAIR 469
            .|.:.   |...||..||:.| |...:...|:|:|:.|  ||.|.|:.|::.:...|......|.
Zfish   575 SSVQS---GLQYFGVSLSQSSPDQTADSLPDIAVGSKG--AVLLLRSRPIMLLETKVSYNPSKIS 634

  Fly   470 ------PEQETITVTACYRLETTSKARQMQQQELTFRMTIDELLQ-RVSFAPMRTNEVSFQAQAG 527
                  ..|...|:..|:.::.....::....::|:.:|:|...| ..:|...:.|.:|.....|
Zfish   635 TGHTDCKNQLQTTLIVCFTMKGYRHHKRDLNAKITYNITLDAKRQNHRAFFSAKDNLLSNVIDIG 699

  Fly   528 LSGSCRNFSVGVHYTGGIFTPIDLELHYELAKKIPHSHEAFCESCA--VVDPLE----------- 579
            .:..|:|                              |:...|:|.  .::||.
Zfish   700 NTEVCKN------------------------------HDFLIEACPEDALNPLSNQLKFTFEGLP 734

  Fly   580 ------------PKYATGT---LSFMTGCAA-HVCVSDLQLSSKDVNSSFI-FGSLEVLSFSYEI 627
                        |:..|.:   |.|...|.. :|||.:|::......|:.| .|.::.::.:..:
Zfish   735 SSQMQNLRPILLPEIKTTSDHDLDFERECGKDNVCVDNLRVDFNFSGSTNIEVGIMQEINVTVFV 799

  Fly   628 TNSGEPAYVAQFNVTSSARLPFAKVPGNCRVRHEVMLCDLNGGRALARGDSE----------SLT 682
            .|.||.:|...|.:.......:.::...   :..|....|:|.:.:..|::|          :..
Zfish   800 ENRGENSYNTHFTLNYPYGFSYRRITSK---QGRVECSSLDGEQGVRLGETECAISKPILKDNTK 861

  Fly   683 IIFDVTQ------LSGQSLTIEAAVSSAGMDQNPKDNTMSTTISLREYAEIDASGGPIDGHIALK 741
            |:|::|.      ..||::...|:|.| |.|::.:.:.:|...|      ||...|.   ::||.
Zfish   862 IVFEITYSINKEVTLGQNVIFSASVKS-GNDKHSESSELSKKKS------IDVKYGI---YVALI 916

  Fly   742 EYPYSA-EVNNSYEFKSHGPSIIDELTVYVDV-PIAYTVTGSAGIKSIFNISSLQMQATHGSELV 804
            .:..|. .:|.:...|.....:...:.:..|: |:|:|    |.|:                  |
Zfish   917 RHENSTIHINFTSGKKDLSKPVQQTIKIENDLRPLAFT----AFIR------------------V 959

  Fly   805 PIKLYDQTNTLAKEYPLEDSSRRANRKRRELQQDQYAIMPDV-NISDILTKENLPANRTLVLDCL 868
            |:||.|  ..:.||..|:.|....|:..:          |.| |..|.:.|.:       ||:|
Zfish   960 PLKLGD--TDIWKESTLQVSDCVKNKTEK----------PSVTNYMDDIKKHH-------VLNC- 1004

  Fly   869 RGNWTIC---------VRSQMRV----------------------QLKPEQPIDLRISFKVDL-N 901
              :..:|         ::::.::                      :|.....:|..:|..|.. :
Zfish  1005 --SVAVCAVFICDVNLIKNERKLYNITGNVSSAWIEQTGLKSAVFELVSTTTMDYDMSTYVFFSS 1067

  Fly   902 DFVNTFDYLVIFTNVEMFKEGDSTSIALKRNLKPNVIFNYSETPLPIWYIILSLIAGHLLLGAMT 966
            |..||...|.|.|.||:::|.|.|.                       .||..:|.|.:||..:|
Zfish  1068 DSRNTAPSLQISTQVEVYEEVDLTK-----------------------EIIGGVIGGLVLLALIT 1109

  Fly   967 YILYKLRFFKRGKKEELKRLLEEHRSE 993
            ..|||..||    |.:.|:::||.:.|
Zfish  1110 AALYKAGFF----KSQYKQMMEEAQGE 1132

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	VCBS	302..375	CDD:338792	24/73 (33%)
		Int_alpha	351..403	CDD:214549	23/53 (43%)
		Int_alpha	417..463	CDD:214549	16/46 (35%)
		Integrin_alpha2	451..836	CDD:337057	79/439 (18%)
itgam.1	XP_005156064.1	vWFA	158..331	CDD:294047	17/174 (10%)
		Int_alpha	456..>498	CDD:214549	15/41 (37%)
		Int_alpha	520..572	CDD:214549	23/51 (45%)
		Integrin_alpha2	616..>908	CDD:285619	57/331 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574957
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940