Protein Alignment ItgaPS5 and itgae.2

DIOPT Version :10

• Sequence 1: NP_611808.2
• Gene: ItgaPS5 / 37732
• FlyBaseID: FBgn0034880
• Length: 1018
• Species: Drosophila melanogaster
• Sequence 2: XP_003200076.2
• Gene: itgae.2 / 100536705
• ZFINID: ZDB-GENE-130530-671
• Length: 1098
• Species: Danio rerio
• Alignment Length: 1016
• Identity: 230/1016 - (22%)
• Similarity: 395/1016 - (38%)
• Gaps: 285/1016 - (28%)

  Fly    56 TSIFVGAPRAQSTLESQGSINETGAVYRCPLASGSCSHYVLNDKLNKQFQWLG------GSMDGG 114
            |.||:....:::..|....:...|.:...|:        .|::.|||. |..|      |..||.
Zfish   269 TDIFIPENGSKNNSEKIIIVLSDGKILGDPM--------TLDEVLNKT-QMKGVTRYSIGVGDGI 324

  Fly   115 TKDTDKL----LVCAPRFFVPKNKNYGQMRGICYWVRDTVADTPPLSDVRTISLIPSQAEEH-FM 174
            .|:.|.:    .:..|..:...: :||.:..|             ||.:.. .:|.::..:| |.
Zfish   325 LKNKDAIKEMTQIADPGKYYSVS-SYGALNDI-------------LSSLER-GIIGTEGTQHGFK 374

  Fly   175 LEL---GLSAHV--TDDNSGFLIGAPGVRSWKGSVLVHRGEDLAAQGSYAVKML-DSWDWVKNHF 233
            |:|   |.|:|:  .:.....|.||.|...|.|.|.:..|.        .||.| ||.:..|  |
Zfish   375 LQLAEAGFSSHLLYNEQKVEALFGAVGAYDWSGGVFLKSGN--------TVKFLNDSHNETK--F 429

  Fly   234 TYVGYALSSGYFSSNNRTSLLYVTTAPSSVLNTGKAYIFDVVGEIVRKLHVFHGEQLGEYFGYSV 298
            .|:||:::|.:..|..    ||::.||...| ||..:|||.:     :.:|.||:|:|.|||..:
Zfish   430 GYLGYSVTSAHLPSKT----LYISGAPRYNL-TGAVFIFDGL-----EKYVLHGDQVGSYFGSVL 484

  Fly   299 VAEDLNGDGLTD-VVVSAP---LNALGDSYDVGAIYVFINKGLFKFEKKIIRLPLSSG---ARFG 356
            .|.|:|.|..|| ::|.||   ||.     :.|.:.|:......:||:..:.|...:|   ||||
Zfish   485 CALDINKDEHTDHLLVGAPHFHLNG-----EEGKVLVYKLNQEDRFERAPVELRGDAGQTFARFG 544

  Fly   357 SSLSKVGDINHDGYNDLAVGAPF--AGNGAVFIFLGSEHGLRDEPSQRLDAPSREPGPYGAHM-- 417
            :::..:|||:::.:||:|||||.  ...|:|:|:.|.|.|||.  ||::     .|..:|..:
Zfish   545 AAIGSIGDIDNNKFNDVAVGAPLETGSAGSVYIYSGFEEGLRF--SQKI-----SPSDFGMKLVY 602

  Fly   418 FGQGLSRG----SDIDGNGFNDLAIGAPGAEAVYLYRAYPVVKIHATVRSESRAIR--------P 470
            |||.:|.|    |||.     .:|:|:.|  .|.::...||:.|..|::.::..|.        .
Zfish   603 FGQSVSVGPAPASDIP-----CIAVGSLG--RVSVFETIPVLIIEPTIKIDTEVIALTHQMNKIS 660

  Fly   471 EQETITVTACYRLETTS-KARQMQQQELTFRMTID------------ELLQRVSFAPMRTNEVSF 522
            .:.::.:|.|:.::... ||.:.:.|.:.:.:.:|            :.|.:.:|......|
Zfish   661 SELSMKITVCFNIKKGKLKAEKSETQAVDYEIDLDSGASKKRLTCGADSLIKDTFTLTPDEE--- 722

  Fly   523 QAQAGLSGSCRNFSVGVHYTG--GIFTPIDLELHYELAKKIPHSHEAFCESCAVVDPLEPKYATG 585
                     |.|..  :.|.|  ..|:||.::|.:.||.   :.:||   ...::|...|.....
Zfish   723 ---------CTNKK--LTYLGCFDCFSPIKIKLSFSLAS---NKNEA---PIRILDAFTPTEVVK 770

  Fly   586 TLSFMTGCAAHVCVSDLQLSSKDVNSSFI-FGSLEVLSFSYEITNSGEPAYVAQFNVTSSARLPF 649
            .:.|...|.|..|...:.||...::.:.| .|..:.|:.::..||:|:|:|.....:|..:.|..
Zfish   771 EIPFEKDCQAADCKPSITLSDSKISETTITMGETQNLNINFNFTNTGDPSYKTTLTLTYPSILSE 835

  Fly   650 AKVPG-----------NCRVRHEVMLCDLNGGRALARGDSESLTIIFDVTQLSGQSLTIEAAVSS 703
            .|:.|           .|.::|.|.             ...:.|.:|...||:.:|
Zfish   836 RKIEGAACPVKNDNQIQCHLQHPVF-------------TRSAQTNLFISWQLNDKS--------- 878

  Fly   704 AGMDQNPKDNTMSTTISLREYAEIDASGGPIDGHIALKEYPYSAEVNNSYEFKSHGPSIIDE--- 765
                                               .||:    :|:..:...:::|..::|.
Zfish   879 -----------------------------------DLKK----SEIIANLTSQNNGIQLLDSRIY 904

  Fly   766 -LTVYVDVPIAYTVTGSAGIKSIFNISSLQMQATHGSELVPIKLYDQTNTLAKEYPLEDSSRRAN 829
             ..|...:||  .:.|||      ..:.|:::.....:..|||.
Zfish   905 TFNVMYFLPI--LIRGSA------EPNILRIEEGGKGKTQPIKF--------------------- 940

  Fly   830 RKRRELQQDQYAIMPDVNISDILTKENLPANRTLVLDCLRGNWTICVRSQMRVQ---------LK 885
             |.:...:::|....||.|:..:.......:.|.:..      .:||....:|:         ||
Zfish   941 -KIQFQGENKYGATIDVIITIKMDTSKTDLHITKIQP------EVCVLEANKVKEASYIYKCTLK 998

  Fly   886 PEQPIDLRISFKVDLNDFVNTFDYLVIFTNVEMFKEG----DSTSIALKRNLKPNVIFNYSETPL 946
            ..|.|  .|...|.::|..:|.:.:::        ||    |.|..:.|..:|...:    |.|:
Zfish   999 ELQII--TIEANVFIHDVQDTSEKIIV--------EGQYSYDETLYSAKDTIKSFTL----EVPV 1049

  Fly   947 PIWYIILS-------LIAGHLLLGAMTYILYKLRFFKRGKK 980
            ....::.|       .|.|.|.|.....||.|..||:|..|
Zfish  1050 TKMQVMTSKGPIIGGSIGGFLFLLIFIIILIKCGFFRRRHK 1090

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	FG-GAP	294..332	CDD:460357	14/41 (34%)
		Int_alpha	351..403	CDD:214549	25/56 (45%)
		Int_alpha	417..463	CDD:214549	16/51 (31%)
		Integrin_alpha2	453..837	CDD:462478	70/422 (17%)
itgae.2	XP_003200076.2	vWFA	180..355	CDD:469594	20/95 (21%)
		Int_alpha	429..>465	CDD:214549	15/40 (38%)
		Int_alpha	477..>517	CDD:214549	16/44 (36%)
		Int_alpha	540..589	CDD:214549	22/50 (44%)
		Integrin_alpha2	635..>850	CDD:462478	46/234 (20%)