DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ItgaPS5 and itga2.2

DIOPT Version :9

Sequence 1:	NP_611808.2	Gene:	ItgaPS5 / 37732	FlyBaseID:	FBgn0034880	Length:	1018	Species:	Drosophila melanogaster
Sequence 2:	XP_003199352.2	Gene:	itga2.2 / 100536533	ZFINID:	ZDB-GENE-091118-70	Length:	1197	Species:	Danio rerio

Alignment Length:	971	Identity:	228/971 - (23%)
Similarity:	415/971 - (42%)	Gaps:	198/971 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 YWVRDTVADTPPLSDVRTISLIPSQ------AEEHFMLEL------------------------- 177
            |::|:.:..:..::::::|:..|::      :||..::|:
Zfish   315 YYIRNDIDTSKLIAEIKSIASKPTEKFFFNVSEEAALIEIVGTLGDRIFNIEGVGKGTGDNFEME 379

  Fly   178 ----GLSAHVTDDNSGFLIGAPGVRSWKGSVLVH---RGEDLAAQGSYAVKMLDSWDWVKNHFTY 235
                |.||:.|.:....|:||.|..:|.|:| ||   :..|:..:.::. |:|:.    |:|.:.
Zfish   380 MSQVGFSAYQTRNKDVILLGAAGAYNWIGTV-VHQTAQKSDILPKTAFE-KVLED----KSHCSL 438

  Fly   236 VGYALSSGYFSSNNRTSLLYVTTAPSSVLNTGKAYIFDVVGE---IVRKLHVFHGEQLGEYFGYS 297
            :||::|    |..:.:|..||..||.:| :.|:..::.:..:   :|  :....|:|:|.|||..
Zfish   439 LGYSVS----SVTDGSSEYYVAGAPRAV-HRGQVVVYSINSQKQAVV--IDSQRGDQIGSYFGSV 496

  Fly   298 VVAEDLNGDGLTD-VVVSAPLNALGDSYDVGAIYVFI-------NKGLFKFEKKIIRLPLSSGAR 354
            :...|::.||:|| ::|.||:....:..:.|.:|:|.       |:|..:..:|        .||
Zfish   497 LCPVDVDSDGVTDLLLVGAPMYMSEEKAETGRVYMFTITKGILSNQGFLEGSQK--------NAR 553

  Fly   355 FGSSLSKVGDINHDGYNDLAVGAPFAGN--GAVFIFLGSEHGLRDEPSQR-----LDAPSREPGP 412
            ||::::.|.|:|.||::|:.||||...|  ||::|:.|....::.:.|||     ||:..:
Zfish   554 FGTAIAAVPDLNLDGFSDVVVGAPMEANDQGAIYIYYGHRKSIKKQSSQRIVGGKLDSALK---- 614

  Fly   413 YGAHMFGQGLSRGSDIDGNGFNDLAIGAPGAEAVYLYRAYPVV--KIHATVRSESRAIRPEQETI 475
                .||:.|....|::|:...|:|:|..|.......|...||  |:..|....|...:|.:.:.
Zfish   615 ----FFGRSLDGSGDMNGDSIPDVAVGGFGKVVQLWSRGLAVVTAKVSFTPDKISILSKPCRYSG 675

  Fly   476 TVTACYRLE-----TTSKARQMQQQELTFRMTIDELLQ--RVSFAPMRTNEVSFQAQAGLSGS-- 531
            ...:|::.:     |......::..::.:.:|:|..||  |||.....:| :....|.|::.|
Zfish   676 RQVSCFKAKACFSATFKPTNSIRLIDVKYNLTLDADLQDSRVSPRGYFSN-LERVIQKGITVSAQ 739

  Fly   532 --CRNFSVGVHYTGGIFTPIDLELHYELAKKIPHSHEAFCESCAVVDPLEPKYATGTLSFMTGCA 594
              |....|.|..|..:...|.|.:...|...         ::..|:|...|......:.|...|.
Zfish   740 DLCEEHEVYVQETPDLVNSIALRVDVFLGNP---------DANPVLDVFSPNAWEFFIPFSKDCG 795

  Fly   595 A-HVCVSDLQLSSKDVNSSFIFGSLEV--------LSFSYEITNSGEPAYVAQFNVTSSARLPFA 650
            . .||:|||.|:   |.|....|...:        |||:..:.|..|.||..:.:.:.|:.|.::
Zfish   796 QDDVCLSDLVLT---VESEEKLGKTPLVVSQNKRRLSFTVTVMNRKENAYNTRVSASYSSNLFYS 857

  Fly   651 KVPG-------NCRVRHE--VMLCDLNGGRALARGDSESLTII---FDVTQLSGQSLTIEAAVSS 703
            .|..       .|....|  :::|.::  ....|.|..:..::   |::.|:..:: .::....|
Zfish   858 SVTPLVEGTEVKCTPIKESNILMCQVS--YPALRTDQLATFVVNFDFNLNQIKKEA-KVDFEALS 919

  Fly   704 AGMDQNPKDNTMSTTISLREYAEIDAS-GGPIDGHIALKEYPYSAEVNNSYEFKSHGPSIIDELT 767
            ...::.|.||.:|.:|.::..:||..| ...||.::..|:..:...|.|   :|..||.....|.
Zfish   920 DSTEETPADNKISISIPVQYNSEIILSRESNIDVYLLEKDNNFLTTVQN---YKDIGPDFNFNLK 981

  Fly   768 VYVDVPIAYTVTGSAGIKSIFNISSLQMQATHGSELV---PIKLYDQTNTLAKEYPLEDSSRRAN 829
            |         .||:..:..::...||......|:.|:   .||.......|.|:..|.|..:
Zfish   982 V---------STGTVPVSLVYLNISLPNNTRAGNPLLYTSRIKTSPADKILCKDNDLIDPLK--- 1034

  Fly   830 RKRRELQQDQYAIMPDVNISDILTKENLPANRTLVLDCLRGNWTICVRSQMRVQLKP-EQPIDLR 893
                      .::.|.   |...|:|:.  ..|..|:|.    |...|: ::..||. :|..|..
Zfish  1035 ----------ISVKPH---SARFTEESF--RGTDELNCR----TASCRA-VQCTLKDLDQKSDYY 1079

  Fly   894 ISFKVDLNDFVNTF---DYLVIFTNVE----------MFKEGDSTSIALKRNLKPNVIFNYSETP 945
            |:  |..|.:..||   |:|.:..:|.          :|.|.....:.:|.: ||.     ::..
Zfish  1080 IN--VTTNIWNGTFVMADFLYVVLSVRADIETSQPDLLFIEQKQLKVEVKVS-KPG-----AKAD 1136

  Fly   946 LPIWYIILSLIAGHLLLGAMTYILYKLRFFKRGKKEELKRLLEEHRSETKEPATDCEGNQE 1006
            :|:..|:.|:|.|.|||.....:||||.||||..:..:|.  ||:.:|.:|...:.|.:.|
Zfish  1137 VPVGAIVGSIIGGLLLLALAVAVLYKLGFFKRKYQPLMKG--EENGAEVQELQENNEASGE 1195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	VCBS	302..375	CDD:338792	24/80 (30%)
		Int_alpha	351..403	CDD:214549	22/58 (38%)
		Int_alpha	417..463	CDD:214549	14/47 (30%)
		Integrin_alpha2	451..836	CDD:337057	88/422 (21%)
itga2.2	XP_003199352.2	Int_alpha	47..95	CDD:214549
		vWFA	174..354	CDD:294047	6/38 (16%)
		Int_alpha	437..475	CDD:214549	11/42 (26%)
		Int_alpha	489..537	CDD:214549	15/47 (32%)
		Int_alpha	551..604	CDD:214549	21/52 (40%)
		Int_alpha	615..>637	CDD:214549	7/21 (33%)
		Integrin_alpha2	647..1067	CDD:285619	98/470 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574910
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.940