Protein Alignment ItgaPS5 and itga4

DIOPT Version :10

• Sequence 1: NP_611808.2
• Gene: ItgaPS5 / 37732
• FlyBaseID: FBgn0034880
• Length: 1018
• Species: Drosophila melanogaster
• Sequence 2: XP_002932062.3
• Gene: itga4 / 100487924
• XenbaseID: XB-GENE-960093
• Length: 1030
• Species: Xenopus tropicalis
• Alignment Length: 1070
• Identity: 269/1070 - (25%)
• Similarity: 446/1070 - (41%)
• Gaps: 227/1070 - (21%)

  Fly    43 RSSYFGYSLVIRPTS----IFVGAPRAQSTLESQGSINETGAVYRCPL---ASGSCSHYVLND-- 98
            :.|.||:|:|:....    |.||||::..|.:   ::...||:.:|.:   .:|||....|.:
 Frog    47 QGSLFGFSVVLHSNGDGNWIVVGAPQSSWTTK---NVTNPGAILKCRIEQNPNGSCDVLELGNLN 108

  Fly    99 --------KLNKQFQWLGGSMDGGTKDTDKLLVCAPRFFVPKN-----KNYGQMRGICYWV---- 146
                    |..:..||||.|:...:....::|.|..|:   ||     .::....|:||.:
 Frog   109 GAKCGKTCKEEQDNQWLGVSLSRQSTKDGQILACGHRW---KNIHFMLSDHKLPYGVCYGIPANF 170

  Fly   147 RDTVAD--TPPLSD-VRTISLIPSQAEEHFMLELGLSAHVTDDNSGFLIGAPGVRSWKGSVLVHR 208
            |..::.  .|...| ||..      .:.:...:.|:|....:|  ..::||||...|.||:.|:.
 Frog   171 RTELSKRICPCYKDHVRKF------GDSYGSCQAGISTFYVED--VIVMGAPGSFYWTGSIFVYN 227

  Fly   209 GEDLAAQGSY-----AVKMLDSWDWVKNHFTYVGYALSSGYFSSNNRTSLLYVTTAPSSVLNTGK 268
            ..:...: ||     |||.          .:|:||::.:|:|.:.|  |...:..||... .|||
 Frog   228 TTENTIK-SYVDLNNAVKF----------GSYLGYSVGAGHFRTPN--SYEVIGGAPQQE-QTGK 278

  Fly   269 AYIFDVVGEIVRKLHVFHGEQLGEYFGYSVVAEDLNGDGLTDVVVSAPLNALGDSYDVGAIYVFI 333
            ||||....:.:..|....|::||.|||.:|.|.|||||||:|::|.||:.:  ...:.|.::|::
 Frog   279 AYIFTYEEKQLVILFEAGGKKLGSYFGAAVCAVDLNGDGLSDLLVGAPMQS--TIREEGRVFVYM 341

  Fly   334 NKGLFKFEKKIIRLPLSS----GARFGSSLSKVGDINHDGYNDLAVGAPFAGN--GAVFIFLGSE 392
            |.|....|:  ::..||.    .||||.:::.:|||::||:.|:|:.||..|:  |||:|:.|.|
 Frog   342 NTGGGAMEE--LQFELSGSDLYAARFGDTIANLGDIDNDGFEDVAIAAPQEGDLEGAVYIYNGRE 404

  Fly   393 HGLRDEPSQRLDAPSREPGPYGAHMFGQGLSRGSDIDGNGFNDLAIGAPGAEAVYLYRAYPVVKI 457
            .|:....||||..   ....||..||||.:|...||||||:||:||||..:::..|.|..||:.|
 Frog   405 KGITPSFSQRLQG---SKFGYGLRMFGQSISNVLDIDGNGYNDVAIGAFLSDSAVLLRTRPVIVI 466

  Fly   458 HATVRSESRAIRPEQE---------TITVTACYRLETTSKARQMQQQELTFRMTIDELLQRVSFA 513
            .|:::......:...|         .:.||.|:..:.......:   .:.:.:|.|  ::|.|..
 Frog   467 DASLKLPMTVNKTRFECMENGAPAVCMNVTICFAYKGLDVPGYI---VMYYNITSD--VRRKSGT 526

  Fly   514 PMRTNEVSFQAQAGLSGSCRNFSVGVHYTGG---------------IFTPIDLELHYELAKKIPH 563
            |.|...||......:||     ::.:|...|               |||||.:|..|.|.|
 Frog   527 PARFYFVSNGTSDVMSG-----TMNIHQKSGNCKTHKAFMRKDTRDIFTPIHMESSYYLGK---- 582

  Fly   564 SHEAFCESCAVVDPLEP---------KYATGTLSFMTGCAAHVCVSDLQLSSK-------DVNSS 612
             |.....|...:.||:|         ...|..:.|...|....|.:|||::.|       :....
 Frog   583 -HIVSKRSADDLQPLQPVLQQKEGKGNVITNKVHFARHCTLLNCSADLQITGKLSFPKPFESKLY 646

  Fly   613 FIFGSLEVLSFSYEITNSGEPAYVAQFNVTSSARLP----FAKV------PGNCRV---RHEVML 664
            ...|.::.|..:..:.|.|:.|    |......|||    |.||      ..:|.|   .:|...
 Frog   647 LAVGGMKSLMINITLFNGGDDA----FQTVLQLRLPKGLYFVKVFDMLEKEISCAVNKEENEQTR 707

  Fly   665 CDLNGGRALARGDS-ESLTIIFDVTQL--SGQSLTIEAAVSSAG--MDQNPKDNTMSTTISLREY 724
            .|.:.|.......| :..:.:.|.:.|  :.:.|.|.|.|:...  .:....:|.:|..:..|..
 Frog   708 LDCSVGHFYVDAFSKQEFSFLLDSSALTRAEEDLVINATVACENEFTEDTIWNNEVSFIVPTRYE 772

  Fly   725 AEIDASG---------GP----IDGHIALKEYPYSAEVNNSYEFKSHGPSIIDELTVYVDVPIAY 776
            .:::..|         ||    .||...:::..::..|.|:      |.|::....:.:.:|..:
 Frog   773 IDLNVLGTVSPFSFVFGPHEDEPDGACIMEKIEFTFNVINA------GSSLVPAAKLQISLPNTF 831

  Fly   777 TVTGSAGIKSIFNISSLQMQATHGSELVPIKLYDQTNTLAKEYPLEDSSRRANRKRRELQQDQYA 841
            :..|      :..:..|.::.|.|      :.|....|...|.|....|:
 Frog   832 SPNG------VKLLDILAVKTTVG------ECYFDNYTRGCETPKNTRSK--------------- 869

  Fly   842 IMPDVNISDILTKENLPANRTLVLDCLRGN----WTICVRSQMRVQLKPEQPIDLRISFKVDLND 902
                  :.|:....:.|..|.|.  |::.:    ..:|:...|..:.|....:.|.||     :.
 Frog   870 ------VGDLFAFFSRPDKRWLY--CMKDDPSCIQILCLFGDMERESKATVEVQLEIS-----HS 921

  Fly   903 FVNTFDYLVI--FTNVEMFKEGDSTSIALKRNLKPNVIF----NYSETPLPIWYII-LSLIAGHL 960
            ::.|.:..:|  ||..:...|.....|.|.::....|:.    |:......|:.|| :||:.|.|
 Frog   922 YLETDEATLIQFFTTAQAGFEDSPKIINLNQDHHAYVVLEALHNHKPKKHVIYLIIGISLLLGIL 986

  Fly   961 LLGAMTYILYKLRFFKR-----GKKEELKR 985
            |...:||||:|:.||.|     |.:|..:|
 Frog   987 LFSLLTYILWKVGFFNRKYQPIGTEETSRR 1016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	FG-GAP	294..332	CDD:460357	16/37 (43%)
		Int_alpha	351..403	CDD:214549	23/57 (40%)
		Int_alpha	417..463	CDD:214549	23/45 (51%)
		Integrin_alpha2	453..837	CDD:462478	88/454 (19%)
itga4	XP_002932062.3	Int_alpha	47..98	CDD:214549	14/53 (26%)
		Int_alpha	301..347	CDD:214549	21/47 (45%)
		Int_alpha	363..415	CDD:214549	23/51 (45%)
		Int_alpha	426..>464	CDD:214549	20/37 (54%)
		Integrin_alpha2	461..898	CDD:462478	93/496 (19%)