Protein Alignment ItgaPS5 and itga4

DIOPT Version :10

• Sequence 1: NP_611808.2
• Gene: ItgaPS5 / 37732
• FlyBaseID: FBgn0034880
• Length: 1018
• Species: Drosophila melanogaster
• Sequence 2: XP_068079775.1
• Gene: itga4 / 100331333
• ZFINID: ZDB-GENE-110411-108
• Length: 1018
• Species: Danio rerio
• Alignment Length: 1089
• Identity: 262/1089 - (24%)
• Similarity: 453/1089 - (41%)
• Gaps: 259/1089 - (23%)

  Fly    45 SYFGYSLVIRP----TSIFVGAPRAQSTLESQGSINETGAVYRCPLASGSCSHYVL--------- 96
            |.||||:::..    |.:.||||.|.|:.  ..:|...||:|.|.:.:..|....:
Zfish    46 SLFGYSVLLHQHNENTWLLVGAPVANSSF--YPNIKSPGAIYNCSMLNSQCEQLPVGGVQRCGRH 108

  Fly    97 ----NDKLNKQFQWLGGSMDGGTKDTDK--LLVCAPR----FFVPKNKNYGQMRGICYWVRDTVA 151
                ||.     ||||.|:   ::...|  :|.|..|    |:..|:.......|:|:      .
Zfish   109 CLAENDN-----QWLGVSL---SRQASKGHVLACGHRWKNVFYSSKDNQNKLPHGVCF------R 159

  Fly   152 DTPPLSDVRTISLIPSQ-------AEEHFMLELGLSAHVTDDNSGFLIGAPGVRSWKGSVLVHRG 209
            .:|.|.....|  ||..       .|.:...:.|:|...|:|.  .::||||...|.|||||
Zfish   160 FSPDLKHASHI--IPCYKDHQRRFGEGYGSCQAGISNSFTEDL--MVMGAPGTSYWTGSVLV--- 217

  Fly   210 EDLAAQGSYAVKMLDSWDWVKNHFTYVGYALSSGYFSSNNRTSLLYVTTAPSSVLNTGKAYIFDV 274
              :....:.:...:|. |....:.:|:||::|:|:|.....|.:  |..||... .|||||||.:
Zfish   218 --VNTTSNISAAYVDD-DSDVLYGSYLGYSVSAGHFLDPQSTEI--VGGAPQHE-QTGKAYIFRI 276

  Fly   275 VGEIVRKLHVFHGEQLGEYFGYSVVAEDLNGDGLTDVVVSAPLNALGDSYDVGAIYVFINKGLFK 339
            .|..::.::...|:.||.|:|.||.|.|||.|||:|::|.||:  .....:.|.:||:||:|..:
Zfish   277 EGNTLKIVNKTKGKTLGSYYGASVCAVDLNADGLSDLLVGAPM--FSSVREEGRVYVYINQGEAE 339

  Fly   340 FEKKIIRLPLSS--GARFGSSLSKVGDINHDGYNDLAVGAPFAGN--GAVFIFLGSEHGLRDEPS 400
            .::....|..|.  .||||.::..:|||:.|||.|:|:|||...:  ||::|:.|...|:....|
Zfish   340 LKEADFELVGSDSYAARFGETIINLGDIDDDGYPDVAIGAPQEDDLRGAIYIYNGRRSGIARSFS 404

  Fly   401 QRLDAPSREPGPYGA------HMFGQGLSRGSDIDGNGFNDLAIGAPGAEAVYLYRAYPVVKIHA 459
            ||:.         |:      .||||.:|.|.|||.|.:.|:|:||..:::..::|..||||:.|
Zfish   405 QRIT---------GSLLGNNFRMFGQSVSGGVDIDSNNYPDVAVGAFLSDSAVVFRTRPVVKVDA 460

  Fly   460 TV---RSESRAIRPEQET------ITVTACYRLETTSKARQMQQQ-ELTFRMTID-----ELLQR 509
            .:   .|.:|::....|.      |.|..|:|:    :.:|:... ||.:.:|.|     ....|
Zfish   461 VMLLPESLNRSVAQCTENGQPAVCIKVRVCFRV----RGKQIPGNIELKYNLTADVHHKEGFPSR 521

  Fly   510 VSFAPMRTNEVS--------------FQAQAGLSGSCRNFSVGVHYTGGIFTPIDLELHYELAKK 560
            ..|:...|:.|:              |. ||.:....|:          |||||..|:.|||.:
Zfish   522 FYFSGNGTSNVTAGRVKAKHEQLTCVFH-QAFMKKDVRD----------IFTPIHFEVKYELGE- 574

  Fly   561 IPHSHEAFCESCAVVDPLEP---------KYATGTLSFMTGCAAHVCVSDLQLSSKDVNSS---- 612
                |.........:..|:|         ........|...|:...|.::||:|::.|...
Zfish   575 ----HRVVQRDLGDLPALKPILQQKDELDNVIKNKTIFARYCSWENCSTNLQVSARLVLPQSYNK 635

  Fly   613 ---FIFGSLEVLSFSYEITNSGEPAYVAQFNVTSSARLPFAKVPGNCRVRHEVMLCDLNGGRALA 674
               |..|:.:.:..:..:.|:|:.|::.:.::...:.|.|.||    ....:::.|::.....||
Zfish   636 MPYFALGNGKSIMLNTTLLNTGDDAFLPKLHLRFPSNLHFIKV----LEEDKLVSCEIVEENKLA 696

  Fly   675 RG-------------DSESLTIIFDVTQ-LSGQSLTIEAAVSSAGMDQN--PKDNTMSTTISLRE 723
            .|             ...::|.:.||.| .|...||:....:|...:..  ..||..:.|:.||.
Zfish   697 IGLDCSVGNLYMPPFSKLNITFLLDVMQNSSAGDLTVNINATSENFENADLQHDNVAALTLPLRY 761

  Fly   724 YAEIDASG--------------GPIDGHIALKEYPYSAEVNNSYEFKSHGPSIIDELTVYVDVPI 774
            ..:::..|              .|:|        .|..:.|.:|:..:.|||...:..|.:.:|:
Zfish   762 AVDMNVHGFVSPNLFIIGEEESVPVD--------CYPEKFNYTYKVMNIGPSKARDARVKISLPL 818

  Fly   775 AYTVTGSAGIKSIFNISSLQMQATHGSELVPIKLYDQTNTLAKEYPLEDSSRRANRKRRELQQDQ 839
            ...:..    ..:..|:.:|....|        .:.:.||:   :.::|..
Zfish   819 MLVLYK----HQLIRITDIQSTLGH--------CFQRNNTI---HIIDDCD-------------- 854

  Fly   840 YAIMPDVNISDILTKENLPANRTLV-----------LDCLRGNWTICVRSQMRVQLKPEQPIDLR 893
               :|:.::...|.....|.::.::           ::|..|:.              |...::.
Zfish   855 ---VPEASVIQELVFFFSPKSKRIMFCGPEDQTCRTVECRFGDL--------------EAGKEVT 902

  Fly   894 ISFKVDLNDFV-----NTFDYLVIFTNVEMFKE-GDSTSIALKRNLKPNVIFN--YSETPLP--- 947
            |:.:|:||..|     .....::|..::::... .|:.:..|:.::...|:..  |:..|.|
Zfish   903 INMEVELNPRVLQMSPGRHAVMMIHGSIDLISPVRDANTFLLQDDVSARVMVEALYTHNPGPVVR 967

  Fly   948 IWYIILSLIAGHLLLGAMTYILYKLRFFKRGKKEELKR----LLEEHRS 992
            |:.|:.|||.|.::.|.:...|:||.||||..||:.:|    .:.:|.|
Zfish   968 IFIIVSSLIVGLIIFGLLVLTLWKLGFFKRTLKEKFRRDSWDYVPKHES 1016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	FG-GAP	294..332	CDD:460357	16/37 (43%)
		Int_alpha	351..403	CDD:214549	22/55 (40%)
		Int_alpha	417..463	CDD:214549	20/48 (42%)
		Integrin_alpha2	453..837	CDD:462478	87/458 (19%)
itga4	XP_068079775.1	Int_alpha	44..99	CDD:214549	18/54 (33%)
		Int_alpha	238..281	CDD:214549	18/45 (40%)
		Int_alpha	293..>336	CDD:214549	21/44 (48%)
		Int_alpha	355..407	CDD:214549	22/51 (43%)
		Int_alpha	415..>460	CDD:214549	19/44 (43%)
		Integrin_alpha2	453..845	CDD:462478	84/435 (19%)