DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS5 and itgav

DIOPT Version :9

Sequence 1:	NP_611808.2	Gene:	ItgaPS5 / 37732	FlyBaseID:	FBgn0034880	Length:	1018	Species:	Drosophila melanogaster
Sequence 2:	XP_012825487.1	Gene:	itgav / 100144691	XenbaseID:	XB-GENE-488969	Length:	1034	Species:	Xenopus tropicalis

Alignment Length:	1084	Identity:	265/1084 - (24%)
Similarity:	455/1084 - (41%)	Gaps:	215/1084 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 SYFGYSLVIRPTS-----IFVGAPRAQSTLESQGSINETGAVYRCPLASGSC----------SHY 94
            ||||:::....:.     :.||||:|.:   ||..|.|.|.|.:|...:..|          .:|
Frog    37 SYFGFAVDFLNSDSSGSYLLVGAPKANT---SQPGIIEGGDVIKCDWKNSECRSVVFDPNGNRNY 98

  Fly    95 VLNDKLN-KQFQWLGGSMDGGTKDTDKLLVCAPRF-FVPKNKNYGQMRGICYWVRD--TVADTPP 155
            .:|:.:. |..||.|.|:   ....:|::.|||.: :..:.|...:..|.|| :.|  ||.:..|
Frog    99 AVNESIEFKSHQWFGASV---RAKHNKIMACAPLYHWRTEIKQEREPVGTCY-LNDGITVVEYAP 159

  Fly   156 L-SDVRTISLIPSQAEEHFMLELGLSAHVTDDNSGFLIGAPGVRSWKGSVLVHRGEDLAAQ---G 216
            . |:.:|      .|:|....:.|.|...|:||. .|:|.||...|:|.::..:.:::..:   .
Frog   160 CRSNAKT------DAQEQGFCQGGFSIDFTEDNR-VLLGGPGSFYWQGQLISDQVDEIVKKYKPE 217

  Fly   217 SYAVKMLD---------SWDWVKNHFTYVGYALSSGYFSSNNRTSLLYVTTAPSSVLNTGKAYIF 272
            .|::...:         |:|     .:|:||:::.|.||.:|...  :|:..|.:....|...|:
Frog   218 KYSITYENQLATRPASLSYD-----DSYLGYSVTVGDFSGDNIED--FVSGVPRAAKTLGMVSIY 275

  Fly   273 DVVGEIVRKLHVFHGEQLGEYFGYSVVAEDLNGDGLTDVVVSAPL----NALGDSYDVGAIYVFI 333
            |  |:.:..|:.|.|||:..||||||...|:|||||.|:.:.|||    .:.|...::|.:.|::
Frog   276 D--GKTMTSLYNFTGEQMAAYFGYSVATSDINGDGLVDLFIGAPLFMDRGSDGKLQELGQVSVYL 338

  Fly   334 NKGLFKFEKKIIRLPLSSG----ARFGSSLSKVGDINHDGYNDLAVGAPFAG---NGAVFIFLGS 391
            .... ...:.:|:|   :|    |||.|.:..:|||:.||:||||:.||:.|   .|.|:|:.|.
Frog   339 QHST-NGPQHLIKL---TGFEIFARFSSCIGPLGDIDGDGFNDLAIAAPYGGVNKKGLVYIYNGR 399

  Fly   392 EHGLRDEPSQRLDAPSREPGPYGA-HM---FGQGLSRGSDIDGNGFNDLAIGAPGAEAVYLYRAY 452
            .:|:...|||.|:      |.:.: ||   ||..|...:|:|.||:.||.:||.||:...||||.
Frog   400 PNGMSIVPSQILE------GQWASQHMPSSFGYSLKGATDVDENGYPDLLVGAFGADKAILYRAR 458

  Fly   453 PVVKIHATVRSESRAIRPEQETITV-----TACYRLETTSKA--RQMQQQELTFRMTI--DE--- 505
            ||:.:.:.:......:.||.:|.::     .:|:.::...||  :....|:|.||:.:  |:
Frog   459 PVITVTSLLEVNPTILNPESKTCSLPSGSKVSCFYVKFCLKAVGKGRVPQDLPFRVDVMLDKHKQ 523

  Fly   506 --LLQRVSFAPMR--TNEVSFQAQAGLSGSCRNFSVGVHYTGGI---FTPIDLELHYELAKKIPH 563
              .::|..|...|  ::..:...|.|....|......:......   .|||.:.:.:::
Frog   524 KGAIRRALFLHTRLSSHSKNMTIQNGSGMRCEELQAFLRDDSEFRDKLTPITIFMEFQM------ 582

  Fly   564 SHEAFCESCA---VVDPLEPKYATGTLSFMTGCAA-HVCVSDLQLSSKDVNSSFIFGSLEVLSFS 624
            .:::..:|..   :::...|...|.....:..|.. ::|...|:||.:........|....|:..
Frog   583 DYKSTADSSGLLPILNQFTPTNITKQAHILLDCGEDNICKPSLKLSVESEQKKIFIGDDSPLTLI 647

  Fly   625 YEITNSGEPAYVAQFNVTSSARLPFAKVPGN--------CRVRHE----VMLCDLNGGRALARGD 677
            ....|.||.||.|:..|.......|..|..|        |..:.|    :::|||  |..:..|.
Frog   648 VNAQNQGEGAYEAELVVQMPPETDFIGVIRNNETFSRLSCAFKTENKTHLVVCDL--GNPMKAGT 710

  Fly   678 SESLTIIFDVTQLS--GQSLTIEAAVSSAGMDQNPKDNTMSTTISLREYAEIDASGGPIDGHIAL 740
            .....::|.|.||:  ..|:..:..:.|:...:| .....|..|:|...|.::..|......:.|
Frog   711 QIKAALLFSVHQLTEMDNSVKFDLQIQSSNQYEN-SSTVQSIEIALAVLAAVEVRGVSTPNEVFL 774

  Fly   741 -------KEYPYSAE-----VNNSYEFKSHGPSIIDELTVYVDVP-----------IAYTVTGSA 782
                   |..|.:.|     |.:.:|.:::|||...:..:.:..|           :.|.:.|
Frog   775 PIANWEQKMNPETEEDIGPLVQHIFELRNNGPSGFSKAILNLQWPYRYNNDTLLYIVKYEIDG-- 837

  Fly   783 GIKSIFNISSLQMQATHGSELVPIKL---YDQTNTLAKEYPLEDSSRRANRKRRELQQDQYAIMP 844
                       .|..|...|:.|:.:   ..|:|        |.:..|....|:..::|..|:..
Frog   838 -----------PMNCTSDVEINPLNVKISASQSN--------EKNESRVPDNRQRNRRDLTAMNG 883

  Fly   845 DVNI-----SDILTKE----NLPANRTLVLDCLRGNWTICV----RSQMRVQLKPEQPID-LRIS 895
            .:..     :|.|..|    .|...::.:|......||:..    .......||...... |...
Frog   884 HLQTLGCGQADCLKIECHVGRLDKGKSAILYVRSRLWTLTFLKNGNQNHSYSLKSSASFSVLEFP 948

  Fly   896 FK-VDLNDFVNTFDYLVIFTNVEMFKEGDSTSIALKRNLKPNVIFNYSETPLPIWYIILSLIAGH 959
            :| :.:.|..|:   .|:.||:....:..|                   .|:|:|.|||::::|.
Frog   949 YKNIHIPDIQNS---TVVTTNILWVNQAAS-------------------LPVPVWVIILAVLSGL 991

  Fly   960 LLLGAMTYILYKLRFFKRGKKEELKRLLEEHRSETKEPATDCEG 1003
            |||..|.:|:|||.||||.:..:     ||...|..:|..:.||
Frog   992 LLLSLMVFIMYKLGFFKRVRPPQ-----EEAEREQLQPQENGEG 1030

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	VCBS	302..375	CDD:338792	28/80 (35%)
		Int_alpha	351..403	CDD:214549	25/58 (43%)
		Int_alpha	417..463	CDD:214549	20/48 (42%)
		Integrin_alpha2	451..836	CDD:337057	83/447 (19%)
itgav	XP_012825487.1	Int_alpha	36..>80	CDD:214549	16/45 (36%)
		WD40 repeat	177..230	CDD:293791	12/53 (23%)
		Int_alpha	237..>277	CDD:214549	13/48 (27%)
		WD40 repeat	243..287	CDD:293791	12/47 (26%)
		Int_alpha	291..344	CDD:214549	19/53 (36%)
		WD40 repeat	296..352	CDD:293791	19/59 (32%)
		Int_alpha	356..411	CDD:214549	24/54 (44%)
		WD40 repeat	361..412	CDD:293791	21/50 (42%)
		Int_alpha	420..466	CDD:214549	20/45 (44%)
		Integrin_alpha2	457..900	CDD:369878	87/472 (18%)
		Integrin_alpha	1003..1017	CDD:334029	7/18 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910