DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pita and su(Hw)

DIOPT Version :9

Sequence 1:	NP_611806.3	Gene:	pita / 37730	FlyBaseID:	FBgn0034878	Length:	683	Species:	Drosophila melanogaster
Sequence 2:	NP_001247098.1	Gene:	su(Hw) / 41740	FlyBaseID:	FBgn0003567	Length:	941	Species:	Drosophila melanogaster

Alignment Length:	670	Identity:	159/670 - (23%)
Similarity:	250/670 - (37%)	Gaps:	184/670 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 PRAPMTMVASKKLLVVPAK---------TAEPSETPKKLLNTMAKSSSQVIIEDVQVLESAMVTP 161
            |.|.:|.|.:.|:...|:|         .|..||      ||.|.::..|:.|:...::..:...
  Fly   109 PSATVTAVETTKIKTSPSKRKKMEHYVLQAVKSE------NTKADTTVTVVTEEDDTIDFILADD 167

  Fly   162 RTVAGSSPVPRRSHAYELKVDNNQEL--SMDDVQSMLEDMASELEKEFPDIPQKASPVKPKVLNK 224
            ..|     ||.|     ::.:|.||:  :.||     ||:..:.:::..|...|.:..:.|:  |
  Fly   168 EEV-----VPGR-----IENNNGQEIVVTEDD-----EDLGEDGDEDGEDSSGKGNSSQTKI--K 215

  Fly   225 SSIRILNKGPAAPVEPRLATPKVK----RDDSGNVAIVTEVLDSDLPLDDQDDPTKNAEKVATDV 285
            ..:..: .|.......|:.:.|..    |.|||......::|             ||.||:..|.
  Fly   216 EIVEHV-CGKCYKTFRRVQSLKKHLEFCRYDSGYHLRKADML-------------KNLEKIEKDA 266

  Fly   286 -----------------------FPCPDCERSFPLQQLLEIH-RLNHTRSRSFQCLLCEKSFFSK 326
                                   ..||||.:||..|...|.| .:.|:....|.|.:|..:..|:
  Fly   267 VVMEKKDICFCCSESYDTFHLGHINCPDCPKSFKTQTSYERHIFITHSEFSDFPCSICNANLRSE 331

  Fly   327 YDLAKHNFVHTGE-RPFKCAICSKAFTRKALLHRHE----------------------------R 362
            ..||.|...|... :|:.|.||.|.|||...|.||:                            |
  Fly   332 ALLALHEEQHKSRGKPYACKICGKDFTRSYHLKRHQKYSSCSSNETDTMSCKVCDRVFYRLDNLR 396

  Fly   363 TH------TDV---PKFICVYCEKPFLSRQEMEKHAERHQKKRPFQCGVCTKSFAFKQGLERHET 418
            :|      |.|   |:::|..|:..|.|...:..|...|..::||.|.:|.|.|:....|::|..
  Fly   397 SHLKQHLGTQVVKKPEYMCHTCKNCFYSLSTLNIHIRTHTGEKPFDCDLCDKKFSALVALKKHRR 461

  Fly   419 VHSTNLPFPCQHCERSFSTASKLARHLVAHAGKRAYPCKYCHKSYMLSHHLSRHLRTHTQTSDAS 483
            .|:...|:.|..|.::|:....|.||:..|.|:|.:.|..|.||::    .:..||||::|....
  Fly   462 YHTGEKPYSCTVCNQAFAVKEVLNRHMKRHTGERPHKCDECGKSFI----QATQLRTHSKTHIRP 522

  Fly   484 FVCSECKVSYSNYNDLLDHALIHATAS---LKCPMCRKQIEDIDSVESHMDQHKQS--------- 536
            |.|.:|...:.....|..|...|:...   ..|..|::.......::.|||:.|.|
  Fly   523 FPCEQCDEKFKTEKQLERHVKTHSRTKRPVFSCAECKRNFRTPALLKEHMDEGKHSPKQQRSSMR 587

  Fly   537 ------ERHACEFCDHIFLTQKCLQRHI------EDDHVVEMEPYQN-------EFED------- 575
                  ||..|..||..|.:...|:|||      :.|.:..:||:.:       |.|:
  Fly   588 SAVKIMERTDCAICDKNFDSSDTLRRHIRTVHECDPDDIFGVEPHPSKRAKKDIESEEVVPVALN 652

  Fly   576 -----------DGEG----EGGVDEKEEHLDDFEDMDNVKQEEFVTEYLEDDALYEDHLDDSDES 625
                       ||.|    |..|||.    |.......::.|.:....| |.|:..:.|  :||:
  Fly   653 TSAGSLISSQTDGNGVVVREFLVDEG----DGAAQTITLENETYTILPL-DGAIEGEQL--TDEA 710

  Fly   626 FTPPPPKQRKTNPPKDAQQS 645
            ...|..|:      ::||.|
  Fly   711 GVKPEAKK------EEAQVS 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pita	NP_611806.3	zf-AD	17..92	CDD:214871
		COG5048	<281..506	CDD:227381	74/286 (26%)
		C2H2 Zn finger	288..308	CDD:275368	9/20 (45%)
		C2H2 Zn finger	316..336	CDD:275368	6/19 (32%)
		zf-H2C2_2	328..353	CDD:290200	10/25 (40%)
		C2H2 Zn finger	344..364	CDD:275368	11/47 (23%)
		C2H2 Zn finger	372..388	CDD:275370	4/15 (27%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	428..448	CDD:275368	6/19 (32%)
		C2H2 Zn finger	456..476	CDD:275368	6/19 (32%)
		C2H2 Zn finger	486..506	CDD:275368	4/19 (21%)
		HARE-HTH	<566..625	CDD:294801	18/87 (21%)
su(Hw)	NP_001247098.1	C2H2 Zn finger	292..313	CDD:275368	9/20 (45%)
		COG5048	<312..517	CDD:227381	58/208 (28%)
		C2H2 Zn finger	321..341	CDD:275368	6/19 (32%)
		zf-C2H2	348..368	CDD:278523	10/19 (53%)
		C2H2 Zn finger	350..368	CDD:275368	10/17 (59%)
		C2H2 Zn finger	382..402	CDD:275368	2/19 (11%)
		C2H2 Zn finger	415..435	CDD:275368	5/19 (26%)
		zf-H2C2_2	428..451	CDD:290200	7/22 (32%)
		C2H2 Zn finger	443..463	CDD:275368	6/19 (32%)
		zf-H2C2_2	455..479	CDD:290200	6/23 (26%)
		COG5048	<467..620	CDD:227381	42/156 (27%)
		C2H2 Zn finger	471..491	CDD:275368	6/19 (32%)
		zf-H2C2_2	484..508	CDD:290200	10/27 (37%)
		C2H2 Zn finger	499..519	CDD:275368	8/23 (35%)
		C2H2 Zn finger	525..545	CDD:275368	4/19 (21%)
		C2H2 Zn finger	555..572	CDD:275368	2/16 (13%)
		C2H2 Zn finger	598..615	CDD:275371	6/16 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446714
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940