DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pita and CTCF

DIOPT Version :9

Sequence 1:	NP_611806.3	Gene:	pita / 37730	FlyBaseID:	FBgn0034878	Length:	683	Species:	Drosophila melanogaster
Sequence 2:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster

Alignment Length:	620	Identity:	138/620 - (22%)
Similarity:	241/620 - (38%)	Gaps:	99/620 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 HCYRFKQMCKRAETLLRQYPLTGNWPSPLEKPRAPMTMVASKKLLVVPAK------TAEPSETPK 133
            :|| .|...|:.:.|  |..|......|.:..|:.::...:|.:.:.|||      |::|...||
  Fly    92 NCY-IKTTPKKQKEL--QKKLKQAAAKPGKATRSVVSTATNKSINLRPAKSTPKATTSKPPPEPK 153

  Fly   134 KLLNTMAKSSSQVIIEDVQVLESAMVTPRTVAGSSPVPRRSHAYELKVDNNQELSMDDVQSMLED 198
            .:....|::::      .:..:|||..|..:....|.||........:...:.:   |::..||:
  Fly   154 AISVRPARAAA------AKAKQSAMPPPPALVVKVPAPRGRPRKNPVIPKPEPM---DLERELEE 209

  Fly   199 MASELEKEFPDIPQKASPVKPKVLNKSSIRILNKGPAAPVEPRLATPKVKRDDSGNVAIVTEVLD 263
            :..|     |||....:.:....::::::    :...|.:.|..|......|::.......:..|
  Fly   210 LVDE-----PDISSMVTELSDYTVDEAAV----EAATATLTPNEAEVYEFEDNATTEDENADKKD 265

  Fly   264 SDLPLDDQDDPTKNAEKVATD------VFPCPDCERSFPLQQLLEIHRLNHTRSRSFQCLLCEKS 322
            .|..|.:::...|.|...:.:      .:.||.|..:...:.|:..|..:|....||:|.:||:|
  Fly   266 VDFVLSNKEVKLKTASSTSQNSNASGHKYSCPHCPYTASKKFLITRHSRSHDVEPSFKCSICERS 330

  Fly   323 FFSKYDLAKHNFVHTGERPFKCAICSKAFTRKALLHRHERTHTDVPKFICVYCEKPFLSRQEMEK 387
            |.|...|..|...|.|.:|.||.:|..|||....|.||.|
  Fly   331 FRSNVGLQNHINTHMGNKPHKCKLCESAFTTSGELVRHTR------------------------- 370

  Fly   388 HAERHQKKRPFQCGVCTKSFAFKQGLERHETVHSTNLPFPCQHCERSFSTASKLARHLVAHAGKR 452
              .:|.|::|.:|..||.:......|.||.|.|:...|:.|.||..:.....||.||:|.|.|::
  Fly   371 --YKHTKEKPHKCTECTYASVELTKLRRHMTCHTGERPYQCPHCTYASQDMFKLKRHMVIHTGEK 433

  Fly   453 AYPCKYCHKSYMLSHHLSRHLRTHTQTSDASFVCSECKVSYSNYNDLLDHALIHATAS---LKCP 514
            .|.|..|...:..|:.|..|...|:......|.|:.|..:.....||..| :.|...|   :.|.
  Fly   434 KYQCDICKSRFTQSNSLKAHKLIHSVVDKPVFQCNYCPTTCGRKADLRVH-IKHMHTSDVPMTCR 497

  Fly   515 MCRKQIEDIDSVESHMDQHKQSERHACEFCDHIFLTQKCLQRHIEDDHVVEMEPYQNEFEDDGEG 579
            .|.:|:.|....:.|:..|:..:.::|:.|.:..:|    |||:....::.:
  Fly   498 RCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVT----QRHLASHMLIHL------------- 545

  Fly   580 EGGVDEKEEHLDDFEDMDNVKQEEFVTEYLEDDALYEDHLD-DSDESFTPPPPKQRKTNPPKDAQ 643
                |||..|.|........:|            |...|:: ..:|.:.||.|:::....|...:
  Fly   546 ----DEKPFHCDQCPQAFRQRQ------------LLRRHMNLVHNEEYQPPEPREKLHKCPSCPR 594

  Fly   644 QSVRQ-TRSRDAQRITQKTGKNEGKPHHKLERNLK 677
            :...: ...|..:.........|.:...||.||::
  Fly   595 EFTHKGNLMRHMETHDDSANAREKRRRLKLGRNVR 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pita	NP_611806.3	zf-AD	17..92	CDD:214871	5/16 (31%)
		COG5048	<281..506	CDD:227381	64/230 (28%)
		C2H2 Zn finger	288..308	CDD:275368	5/19 (26%)
		C2H2 Zn finger	316..336	CDD:275368	8/19 (42%)
		zf-H2C2_2	328..353	CDD:290200	10/24 (42%)
		C2H2 Zn finger	344..364	CDD:275368	9/19 (47%)
		C2H2 Zn finger	372..388	CDD:275370	0/15 (0%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	428..448	CDD:275368	8/19 (42%)
		C2H2 Zn finger	456..476	CDD:275368	5/19 (26%)
		C2H2 Zn finger	486..506	CDD:275368	5/19 (26%)
		HARE-HTH	<566..625	CDD:294801	8/59 (14%)
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226	19/98 (19%)
		C2H2 Zn finger	296..316	CDD:275368	5/19 (26%)
		COG5048	321..>621	CDD:227381	87/360 (24%)
		zf-C2H2	322..344	CDD:278523	9/21 (43%)
		C2H2 Zn finger	324..344	CDD:275368	8/19 (42%)
		zf-H2C2_2	337..361	CDD:290200	10/23 (43%)
		C2H2 Zn finger	352..373	CDD:275368	9/47 (19%)
		C2H2 Zn finger	381..401	CDD:275368	7/19 (37%)
		zf-H2C2_2	394..415	CDD:290200	9/20 (45%)
		C2H2 Zn finger	409..429	CDD:275368	8/19 (42%)
		zf-H2C2_2	422..446	CDD:290200	9/23 (39%)
		C2H2 Zn finger	437..457	CDD:275368	5/19 (26%)
		C2H2 Zn finger	467..485	CDD:275368	5/18 (28%)
		C2H2 Zn finger	496..516	CDD:275370	5/19 (26%)
		C2H2 Zn finger	524..544	CDD:275368	6/23 (26%)
		zf-H2C2_2	536..561	CDD:290200	6/41 (15%)
		C2H2 Zn finger	552..573	CDD:275368	4/32 (13%)
		zf-C2H2	587..609	CDD:278523	2/21 (10%)
		C2H2 Zn finger	589..609	CDD:275368	2/19 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100