DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pita and D19B

DIOPT Version :9

Sequence 1:	NP_611806.3	Gene:	pita / 37730	FlyBaseID:	FBgn0034878	Length:	683	Species:	Drosophila melanogaster
Sequence 2:	NP_477297.1	Gene:	D19B / 38717	FlyBaseID:	FBgn0022699	Length:	774	Species:	Drosophila melanogaster

Alignment Length:	810	Identity:	165/810 - (20%)
Similarity:	279/810 - (34%)	Gaps:	213/810 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 EAMLTEKRVCRFCLTEQKLASIFEENPRVKTTANLPLQIMAITAIEVYAGDGMPGHICLECRLLF 73
            |:..:...|||.||:....::.::    :.....|..::...|::.|...||.|.::|..|....
  Fly     4 ESQYSIHTVCRTCLSTVDDSAAYD----LFRVPGLAKKLCVCTSLSVEQADGFPKNLCNVCFSKL 64

  Fly    74 EHCYRFKQMC------------KRAETLLRQYPLTGNWPSPLEKPRAPMTMVASKKLLVVPAKTA 126
            ...:.|::.|            ..|......:.:.....:..:.|......|....||....:..
  Fly    65 NDLHDFQKQCVDSVQKFQDLVASNAFACQTNFDVLDTSAAVADLPGEEEDNVHFDPLLNSKIEII 129

  Fly   127 EPSETPKKLLNTMAKSSSQVIIEDVQVLESAMVTPRTVAGSSPVPRRSHAYELKVDNNQELSMDD 191
            |..|...|:|.::.|...:|.:|..|                |..|.|.....:..|:.:|.. |
  Fly   130 ENEEDVFKMLESVEKEVEEVEMEMEQ----------------PFGRVSQDDSFESGNDNDLDA-D 177

  Fly   192 VQSMLEDMASELEKEFPDIPQKASPVKPKVLNKSSIRILNKGPAAPVEPRLATPKVKRDDSGNVA 256
            .|...:|          |||          |.:.|.|...:|..|..:|:.|. |.:.::|....
  Fly   178 FQISSDD----------DIP----------LAQRSRRGATRGSKAKGKPKSAA-KRQEEESEESE 221

  Fly   257 IVTEVLDSD-----------LPLDDQDD------------------------------------- 273
            ..:...|||           :|..::|.
  Fly   222 ETSSSDDSDGNPKDKPKRKRIPATERDRHRLIDCHICHQKFKKAIRYEEHMKHHNDLLPFQCTVE 286

  Fly   274 ------PTKNAEKVATD--------VFPC--PDCERSFPLQQLLEIH--RLN--HTRSRSFQCLL 318
                  .|.|..:|..:        :.||  ..|.:||....||..|  |::  .|..|.|.|..
  Fly   287 SCRKGFTTANGLRVHVEHAHTETSAMHPCTYEGCNKSFARPVLLSFHMKRVHKVDTPQRDFPCTE 351

  Fly   319 CEKSFFSKYDLAKHNFVHTGER-PFKCAICSKAFTRKALLHRHERTHTDVPKFICVYCEKPFLSR 382
            |||.|.....|.||.:.||||. ||.|.||.|.|...::|..|...|..:...:|.||.....:|
  Fly   352 CEKVFRCPTALKKHMYKHTGEELPFACEICGKRFPINSVLRDHLLRHAGIKNHVCPYCGVGKTTR 416

  Fly   383 QEMEKHAERHQKKRPFQCGVCTKSFAFKQGLERH-ETVHSTNLPFPCQHCERSFSTASKLARHLV 446
            ||..||...|.|::.::|..|..:...||.|..| :.||.....|.||:|.::|..:.....|..
  Fly   417 QEWNKHILTHTKEKKYECRQCDHASHNKQALANHVKVVHEKRKDFACQYCGKTFGKSHACKIHER 481

  Fly   447 AHAGKRAYPCKYCHKSYMLSHHLSRHLRTH-------TQTSDA--------SFVCSECKVSYSNY 496
            :|.|::...||.|.|.::....|::||:||       ||.::|        |...::........
  Fly   482 SHTGEKCCECKICGKVFLFEKGLTKHLKTHEKRDLPKTQGTNALMGDGASGSSTIAKPSPHLRGR 546

  Fly   497 NDLLDHALIHATASLK-----------------------CPMCRKQIEDIDSVESHMD-QHKQSE 537
            .:.:|.|.:..|.:..                       ||.|.|....:.:::.|.. .|::.:
  Fly   547 VERVDIAQLAGTVANPIPSVNLPSWSPQVNFTKKEGQHICPDCGKGFNHVSNMKLHYKVVHQKVK 611

  Fly   538 RHACEFCDHIFLTQKCLQRHIEDDHVVEMEPYQNEFEDDGEGEGGVDEKEEHLDDFEDMDNVKQE 602
            ...|.||...|..::.| ||.|..|..| :||:.
  Fly   612 DFCCRFCPKRFAKKQYL-RHHEYIHTGE-KPYEC------------------------------- 643

  Fly   603 EFVTEYLEDDALYEDHLDDSDESFTPPPPKQRKTNPPKDAQQSVRQTRSRD-------------- 653
            :...::...:.:.:.|:...|:...||...:....|..::..:|::.:.::
  Fly   644 KVCGKHFRQEQVLKTHMKVHDKPPRPPGKPKEPAGPKAESSTAVKRQQPKNFEQYQDPAAERAAA 708

  Fly   654 -AQRITQKTGKNEGKPHHKLERNLKNRRSA 682
             |:.:..:..:||.|  .|.|..|:..:.|
  Fly   709 TAELLAYQIEENEAK--RKAEAELRKIQEA 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pita	NP_611806.3	zf-AD	17..92	CDD:214871	16/86 (19%)
		COG5048	<281..506	CDD:227381	76/255 (30%)
		C2H2 Zn finger	288..308	CDD:275368	8/25 (32%)
		C2H2 Zn finger	316..336	CDD:275368	8/19 (42%)
		zf-H2C2_2	328..353	CDD:290200	14/25 (56%)
		C2H2 Zn finger	344..364	CDD:275368	7/19 (37%)
		C2H2 Zn finger	372..388	CDD:275370	6/15 (40%)
		C2H2 Zn finger	400..420	CDD:275368	6/20 (30%)
		C2H2 Zn finger	428..448	CDD:275368	5/19 (26%)
		C2H2 Zn finger	456..476	CDD:275368	7/19 (37%)
		C2H2 Zn finger	486..506	CDD:275368	2/19 (11%)
		HARE-HTH	<566..625	CDD:294801	4/58 (7%)
D19B	NP_477297.1	zf-AD	12..83	CDD:214871	15/74 (20%)
		C2H2 Zn finger	255..275	CDD:275368	0/19 (0%)
		C2H2 Zn finger	283..335	CDD:275368	11/51 (22%)
		C2H2 Zn finger	318..338	CDD:275368	7/19 (37%)
		COG5048	<347..512	CDD:227381	57/164 (35%)
		C2H2 Zn finger	349..369	CDD:275368	8/19 (42%)
		C2H2 Zn finger	378..398	CDD:275368	7/19 (37%)
		C2H2 Zn finger	406..426	CDD:275368	8/19 (42%)
		C2H2 Zn finger	434..455	CDD:275368	6/20 (30%)
		C2H2 Zn finger	463..483	CDD:275368	5/19 (26%)
		C2H2 Zn finger	491..511	CDD:275368	7/19 (37%)
		C2H2 Zn finger	586..607	CDD:275368	5/20 (25%)
		C2H2 Zn finger	615..635	CDD:275368	8/20 (40%)
		zf-H2C2_2	627..652	CDD:290200	8/57 (14%)
		C2H2 Zn finger	643..663	CDD:275368	1/50 (2%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449755
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930