Protein Alignment KCNJ16 and Irk3

DIOPT Version :10

• Sequence 1: XP_005257394.1
• Gene: KCNJ16 / 3773
• HGNCID: 6262
• Length: 453
• Species: Homo sapiens
• Sequence 2: NP_001137835.2
• Gene: Irk3 / 35131
• FlyBaseID: FBgn0032706
• Length: 446
• Species: Drosophila melanogaster
• Alignment Length: 325
• Identity: 102/325 - (31%)
• Similarity: 181/325 - (55%)
• Gaps: 12/325 - (3%)

Human    65 RRARRRLLHKDGSCNVYFKHIFGEWGSYVVDIFTTLVDTKWRHMFVIFSLSYILSWLIFGSVFWL 129
            ||:..|::.|:|..||.|:.|..:...|:.|:.|||::.:|::|..:|..||.||||:|.::.::
  Fly   112 RRSLNRVMEKNGKENVVFRRIPEKSWRYMRDLVTTLMELEWKYMLTLFLGSYFLSWLLFAALCYV 176

Human   130 IAFHHGDLLNDP--------DITPCVDNVHSFTGAFLFSLETQTTIGYGYRCVTEECSVAVLMVI 186
            :|:.|||.:.||        .:.||:..|||:....::|:|||||:|:|.:..:|||...:.:.:
  Fly   177 VAYSHGDFIFDPVSGKRMGEGVDPCIYGVHSWVAMIIYSVETQTTLGFGEKYASEECPETIFLFV 241

Human   187 LQSILSCIINTFIIGAALAKMATARKRAQTIRFSYFALIGMRDGKLCLMWRIGDFRPNHVVEGTV 251
            :|.:.:.:|...::....||.|...::...::||..|:|..|||:|||::|:.|.|....:|..:
  Fly   242 MQMLSAALIEGCMVSVIYAKTARPARQLTKLKFSDKAVICYRDGRLCLLFRVCDPREQQSIESKI 306

Human   252 RAQLLRYTEDSEGRMTMAFKDLKLV-NDQIILVTPVTIVHEIDHESPLYAL-DRKAVAKDNFEIL 314
            |..::......||....:..:|||. |.:.|::.|..:.|.||..|||... ..|......||:.
  Fly   307 RVYIIVDKRTREGETIKSHVELKLEGNGEQIILWPDVVCHVIDETSPLSQFTTAKLFNAAQFELY 371

Human   315 VTFIYTGDSTGTSHQSRSSYVPREILWGHRFNDVL--EVKRKYYKVNCLQFEGSVEVYAPFCSAK 377
            |:.:.|..:|....::::||:||||.||.||.:::  :.:.:.|.|:...|..::.|..|..:.|
  Fly   372 VSIVGTSPATAQMTEAKTSYLPREIFWGQRFVNIIHYDAQNERYIVDYENFNRTISVDMPMTNPK 436

Human   378  377
              Fly   437  436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNJ16	XP_005257394.1	IRK	72..208	CDD:460023	47/143 (33%)
		IRK_C	217..384	CDD:465439	51/165 (31%)
Irk3	NP_001137835.2	IRK	119..265	CDD:460023	48/145 (33%)
		IRK_C	272..432	CDD:465439	49/159 (31%)