DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dcp-1 and CFLAR

DIOPT Version :9

Sequence 1:	NP_476974.1	Gene:	Dcp-1 / 37729	FlyBaseID:	FBgn0010501	Length:	323	Species:	Drosophila melanogaster
Sequence 2:	NP_001120655.1	Gene:	CFLAR / 8837	HGNCID:	1876	Length:	480	Species:	Homo sapiens

Alignment Length:	246	Identity:	66/246 - (26%)
Similarity:	104/246 - (42%)	Gaps:	42/246 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 MPVERYASEYNMSHKHRGVALIFNHEFFDIPSLKSRTGTNVDAQELKKAFENLGFAVSVHKDCKL 126
            :|.||    |.|..|..|:.||       |..:.:.|      :.|:..|.:||:.|.......:
Human   239 IPEER----YKMKSKPLGICLI-------IDCIGNET------ELLRDTFTSLGYEVQKFLHLSM 286

  Fly   127 RDILKHVGKAAEL-DHTDNDCLAVAILSHGEHGYLYAKDTQYK---LDNIWHYFTATFCPSLAGK 187
            ..|.:.:|:.|.: :|.|.|.....::|.|....:|..|..:.   |.:|...|....||.||||
Human   287 HGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIRRMFMGDSCPYLAGK 351

  Fly   188 PKLFFIQ---ACQGDRLDGGITLEKGVTETDGESSTSYKI--------PIH--ADFLFSYSTIPG 239
            ||:||||   ..:|...|..:      .|.||.:..:.:.        .:|  |||.:|..|...
Human   352 PKMFFIQNYVVSEGQLEDSSL------LEVDGPAMKNVEFKAQKRGLCTVHREADFFWSLCTADM 410

  Fly   240 YFSWRNINNGSWYMQSLIRELNANGKKYDLLTLLTFVNQRVALDFESNVPA 290
            ....::.::.|.|:|.|.::|... :|..||.|...:|..: .|:.|.|.|
Human   411 SLLEQSHSSPSLYLQCLSQKLRQE-RKRPLLDLHIELNGYM-YDWNSRVSA 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dcp-1	NP_476974.1	CASc	71..313	CDD:214521	63/237 (27%)
CFLAR	NP_001120655.1	Not proteolytically processed and involved in apoptosis inhibition	1..435		57/219 (26%)
		Interaction with CASP8 propeptide. /evidence=ECO:0000269\|PubMed:9208847, ECO:0000269\|PubMed:9326610	1..305		20/82 (24%)
		Interaction with FADD. /evidence=ECO:0000269\|PubMed:9208847, ECO:0000269\|PubMed:9326610	1..227
		Interaction with CASP8. /evidence=ECO:0000269\|PubMed:9208847, ECO:0000269\|PubMed:9326610	1..195
		DED_c-FLIP_r1	1..80	CDD:260044
		DED_c-FLIP_r2	91..171	CDD:260046
		Interaction with TRAF1 and TRAF2. /evidence=ECO:0000269\|PubMed:9208847	192..480		66/246 (27%)
		Interaction with CASP3. /evidence=ECO:0000269\|PubMed:9208847, ECO:0000269\|PubMed:9326610	192..435		57/219 (26%)
		Interaction with CASP8 subunits p18 and p10. /evidence=ECO:0000269\|PubMed:9208847, ECO:0000269\|PubMed:9326610	217..480		66/246 (27%)
		CASc	244..479	CDD:214521	63/237 (27%)
		Caspase	263..358		29/100 (29%)
		Interaction with CASP8. /evidence=ECO:0000269\|PubMed:9208847, ECO:0000269\|PubMed:9326610	370..480		23/98 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810