DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dcp-1 and CASP10

DIOPT Version :9

Sequence 1:	NP_476974.1	Gene:	Dcp-1 / 37729	FlyBaseID:	FBgn0010501	Length:	323	Species:	Drosophila melanogaster
Sequence 2:	NP_116759.2	Gene:	CASP10 / 843	HGNCID:	1500	Length:	522	Species:	Homo sapiens

Alignment Length:	299	Identity:	104/299 - (34%)
Similarity:	152/299 - (50%)	Gaps:	48/299 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GIRSPNGSENRGSFIMADNTDAKGCTPESLVVGGATAASPLPANKFVARMPVERYASEYNMSHKH 77
            |.|:.||:                   .|||..|...||   ||...:....:| |:.|.|:..|
Human   241 GNRATNGA-------------------PSLVSRGMQGAS---ANTLNSETSTKR-AAVYRMNRNH 282

  Fly    78 RGVALIFNHEFFDIPSLKSRTGTNVDAQELKKAFENLGFAVSVHKD---CKLRDILKHVGKAAEL 139
            ||:.:|.|:..|  .|||.|.||:.||:.|...|:.|||.|.:|.:   .::..:|:.  :....
Human   283 RGLCVIVNNHSF--TSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQK--QKCNP 343

  Fly   140 DHTDNDCLAVAILSHGEHGYLYAKD-TQYKLDNIWHYFTATFCPSLAGKPKLFFIQACQGDRLDG 203
            .|.|.||....||:||..|.:|:.| ....:..|..:|||..||.||.||||||||||||:.:..
Human   344 AHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQP 408

  Fly   204 GITLEKGVTETDGESSTSYK--IPIHADFLFSYSTIPGYFSWRNINNGSWYMQSLIRELNANGKK 266
            .:::|......: ::.||.:  ||..||||...:|:|||.|:|::..||||:|||...|.....:
Human   409 SVSIEADALNPE-QAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPR 472

  Fly   267 Y-DLLTLLTFVNQRVALDFESNVPATPMMDRQ---KQIP 301
            : |:|::||.||..|          :..:|:|   ||:|
Human   473 HEDILSILTAVNDDV----------SRRVDKQGTKKQMP 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dcp-1	NP_476974.1	CASc	71..313	CDD:214521	90/241 (37%)
CASP10	NP_116759.2	DD	18..99	CDD:326335
		DED_Caspase_10_r2	112..190	CDD:260074
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	231..269		12/49 (24%)
		CASc	276..514	CDD:214521	90/241 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810