DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dcp-1 and CASP4

DIOPT Version :9

Sequence 1:	NP_476974.1	Gene:	Dcp-1 / 37729	FlyBaseID:	FBgn0010501	Length:	323	Species:	Drosophila melanogaster
Sequence 2:	NP_001216.1	Gene:	CASP4 / 837	HGNCID:	1505	Length:	377	Species:	Homo sapiens

Alignment Length:	291	Identity:	80/291 - (27%)
Similarity:	125/291 - (42%)	Gaps:	38/291 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 PESLVVGGATAASPLPANKFVARMPVERYASEYNMSHKH---RGVALIFNHEFFDIPSLKSRTGT 100
            |||   |.:|.|..|..::...|:..||....|.:..::   |...:|.|.||..:|   .|.|.
Human    97 PES---GESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLP---PRNGA 155

  Fly   101 NVDAQELKKAFENLGFAVSVHKDCKLRDILKHV-GKAAELDHTDNDCLAVAILSHG-EHGYLYAK 163
            :.|...:|:..|.|.::|.|.::...||:...: ..|...:|..:|...:.::||| ..|.....
Human   156 DFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTV 220

  Fly   164 DTQYK-----LDNIWHYFTATFCPSLAGKPKLFFIQACQGDR------LDGGITLEKGVTETDG- 216
            ..:.|     .|.|:..|....|.||..|||:..:|||:|..      .|...:||...:::..
Human   221 HDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSEN 285

  Fly   217 -ESSTSYKIPIHADFLFSYSTIPGYFSWRNINNGSWYMQSLIRELNANGKKYDLLTLLTFVNQRV 280
             |....||..:..||:...|:.|...|||:...||.::..||...    :||.....|..|.::|
Human   286 LEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCF----QKYSWCCHLEEVFRKV 346

  Fly   281 ALDFESNVPATPMMDRQK-QIPCLTSM-LTR 309
            ...||     ||   |.| |:|.:..: :||
Human   347 QQSFE-----TP---RAKAQMPTIERLSMTR 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dcp-1	NP_476974.1	CASc	71..313	CDD:214521	70/259 (27%)
CASP4	NP_001216.1	Required for LPS-binding. /evidence=ECO:0000250\|UniProtKB:P70343	1..59
		CARD_CASP1-like	5..81	CDD:260036
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	84..104		4/9 (44%)
		CASc	126..375	CDD:214521	70/259 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10454
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910