DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dcp-1 and casp8

DIOPT Version :9

Sequence 1:	NP_476974.1	Gene:	Dcp-1 / 37729	FlyBaseID:	FBgn0010501	Length:	323	Species:	Drosophila melanogaster
Sequence 2:	XP_005165894.1	Gene:	casp8 / 58022	ZFINID:	ZDB-GENE-000713-1	Length:	477	Species:	Danio rerio

Alignment Length:	276	Identity:	86/276 - (31%)
Similarity:	126/276 - (45%)	Gaps:	37/276 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 AASPLPANKFVARMPVERYASEYNMSHKHRGVALIF-NHEFFDIPSLKSRTGTNVDAQELKKAFE 112
            |.:||..|::            |.::.:..|..||. |:.|....:|..||||::|...|.|.|.
Zfish   221 AETPLNPNEY------------YILTQRPLGYCLIINNYNFLKSTNLLKRTGTDMDKDRLAKLFS 273

  Fly   113 NLGFAVSVHKDCKLRDILKHVGKAAELDHTDNDCLAVAILSHGEHGYLYAKDTQ-YKLDNIWHYF 176
            .:.|.:.|..|.:...|...:.:.|..:|.........||||||.|.:...|.: .::..:...|
Zfish   274 RMHFQIEVRSDLEAWAIKDEIKQFANKNHASMGAFVCCILSHGEKGTVLGTDGKPVEIREVTLPF 338

  Fly   177 TATFCPSLAGKPKLFFIQACQGDRLDGGITLEKGVTETDGESSTSY----------KIPIHADFL 231
            ..  |.:||.|||||||||||||....|:....| .|...|....|          ||||.||||
Zfish   339 AG--CRTLASKPKLFFIQACQGDENQAGVWTSDG-REDAPEEDEKYEEDAGIIVLRKIPIEADFL 400

  Fly   232 FSYSTIPGYFSWRNINNGSWYMQSLIREL-NANGKKYDLLTLLTFVNQRVALDFESNVPATPMMD 295
            ...:|:..|.|:|:...||.::|.|.::: ....||.|:|::||.||..|         :..::.
Zfish   401 IGMATVEHYLSYRHTKEGSIFIQELCKKMEELCPKKEDMLSILTKVNFEV---------SKRILK 456

  Fly   296 RQKQIPCLTSMLTRIL 311
            ..||:|.....||:.|
Zfish   457 GYKQMPEPRYTLTKKL 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dcp-1	NP_476974.1	CASc	71..313	CDD:214521	82/254 (32%)
casp8	XP_005165894.1	DED_Caspase_8_10_r1	2..76	CDD:260059
		DED_Caspase_8_10_r2	96..176	CDD:260042
		CASc	230..475	CDD:237997	82/267 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810