DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dcp-1 and casp3b

DIOPT Version :9

Sequence 1:	NP_476974.1	Gene:	Dcp-1 / 37729	FlyBaseID:	FBgn0010501	Length:	323	Species:	Drosophila melanogaster
Sequence 2:	NP_001041531.2	Gene:	casp3b / 566604	ZFINID:	ZDB-GENE-070607-1	Length:	285	Species:	Danio rerio

Alignment Length:	247	Identity:	101/247 - (40%)
Similarity:	153/247 - (61%)	Gaps:	12/247 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 EYNMSHKHRGVALIFNHE-FFDIPSLKSRTGTNVDAQELKKAFENLGFAVSVHKDCKLRDILKHV 133
            :|..::.:.|..||.|:: |.....:..|.||:.||:::.:.|..|||.|..:.|..:..::..:
Zfish    46 QYKTNYPNLGQCLIINNKNFHKRTGMGVRNGTDEDAKKVFETFSQLGFKVGHYNDLTVSQMMALL 110

  Fly   134 GKAAELDHTDNDCLAVAILSHGEHGYLYAKDTQYKLDNIWHYFTATFCPSLAGKPKLFFIQACQG 198
            .||::.||:.:...|..:||||:.|.:|..|...:|..::.:|....|.||.|||||||||||:|
Zfish   111 NKASQEDHSKSAMFACVLLSHGDDGLIYGTDNSIELKRLFAHFRGDRCTSLVGKPKLFFIQACRG 175

  Fly   199 DRLDGGITLEKGVTETDGESSTSYKIPIHADFLFSYSTIPGYFSWRNINNGSWYMQSLIRELNAN 263
            ..||.||..: ||    |:..|. :||:.||||::|||.|||::|||:.||||::.||...|...
Zfish   176 TDLDSGIECD-GV----GDEETQ-RIPVEADFLYAYSTAPGYYAWRNVANGSWFISSLCDMLLKY 234

  Fly   264 GKKYDLLTLLTFVNQRVALDFE--SNVPATPMMDRQKQIPCLTSMLTRILRF 313
            ||:.:::.::|.||.:|||:||  ||:|.   .|.:|||||:.||||:.|.|
Zfish   235 GKQLEIMQVMTRVNHKVALEFESSSNLPG---FDGKKQIPCIVSMLTKELYF 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dcp-1	NP_476974.1	CASc	71..313	CDD:214521	100/244 (41%)
casp3b	NP_001041531.2	CASc	47..284	CDD:237997	101/246 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580503
Domainoid	1	1.000	200	1.000	Domainoid score	I2984
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	209	1.000	Inparanoid score	I3655
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D417543at33208
OrthoFinder	1	1.000	-	-		FOG0000242
OrthoInspector	1	1.000	-	-		mtm6547
orthoMCL	1	0.900	-	-		OOG6_103710
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3066
SonicParanoid	1	1.000	-	-		X460
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.690