DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dcp-1 and casp10

DIOPT Version :9

Sequence 1:	NP_476974.1	Gene:	Dcp-1 / 37729	FlyBaseID:	FBgn0010501	Length:	323	Species:	Drosophila melanogaster
Sequence 2:	XP_685430.4	Gene:	casp10 / 557302	ZFINID:	ZDB-GENE-070608-2	Length:	520	Species:	Danio rerio

Alignment Length:	331	Identity:	103/331 - (31%)
Similarity:	153/331 - (46%)	Gaps:	50/331 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GIRS----PNGSENRGSFIMAD--------NTDAKGCT------PESLVVGGATAASPLP--ANK 57
            ||.|    |:...:..|..|.|        |.:|.|.:      .:|:..|..:.:|.:|  .|.
Zfish   204 GISSIADLPSAQTSLSSVEMIDREMDEITLNENASGFSGDNSQHSDSVNSGIISESSEMPQIENS 268

  Fly    58 FVARMPVERYASEYNMSHKHRGVALIFNHEFFDIPSLKSRTGTNVDAQELKKAFENLGFAVSVHK 122
            .|         .:|.|..:.|||.||.|:..|......:|.||::|...|:..||.|||.:...:
Zfish   269 MV---------EQYEMKGERRGVCLIINNYDFSACGWLNREGTDIDHDSLRDVFEWLGFEILTRR 324

  Fly   123 DCKLRDILKHVGKAAELDHTDNDCLAVAILSHGEHGYLYAKDTQ-YKLDNIWHYFTATFCPSLAG 186
            ||....||:.:...:..|||..||:...|||||....:...|.: .....:....:...|.||..
Zfish   325 DCTGDQILQALMDLSTQDHTQADCVVCCILSHGRLNDIIGVDGKAVPFKELMETLSPFRCSSLYQ 389

  Fly   187 KPKLFFIQACQGDRLDGGI-----TLEKGVTETD-GESSTSYKIPIHADFLFSYSTIPGYFSWRN 245
            ||||||||||:|.:....:     |.::.|..:| |....|  ||..||:|.:.||:|.|.|:|:
Zfish   390 KPKLFFIQACRGTQNQRAVFPQTFTEDEDVLASDAGVPRDS--IPEMADYLMAMSTVPWYASYRD 452

  Fly   246 INNGSWYMQSL---IRELNANGKKYDLLTLLTFVNQRVALDFESNVPATPMMDRQKQIPCLTSML 307
            .:.|:|::|||   :|.|...|.  |||::||.||..|:...:.:       ..:||:|.....|
Zfish   453 KSKGTWFIQSLCDNLRLLVPRGN--DLLSILTKVNADVSKKSDKS-------GLKKQMPQPEFSL 508

  Fly   308 TRILRF 313
            ||.:.|
Zfish   509 TRTVVF 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dcp-1	NP_476974.1	CASc	71..313	CDD:214521	86/251 (34%)
casp10	XP_685430.4	DED_Caspase_8_10_r1	11..87	CDD:260059
		DED_Caspase_8_10_r2	108..190	CDD:260042
		DUF4603	<200..>256	CDD:292020	12/51 (24%)
		CASc	273..515	CDD:237997	87/253 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810