DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dcp-1 and ced-3

DIOPT Version :9

Sequence 1:	NP_476974.1	Gene:	Dcp-1 / 37729	FlyBaseID:	FBgn0010501	Length:	323	Species:	Drosophila melanogaster
Sequence 2:	NP_001255708.1	Gene:	ced-3 / 178272	WormBaseID:	WBGene00000417	Length:	503	Species:	Caenorhabditis elegans

Alignment Length:	291	Identity:	87/291 - (29%)
Similarity:	126/291 - (43%)	Gaps:	50/291 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 FVARMPVERYASE---YNMSHKHRGVALIFNHEFFDIPSLKSRTGTNVDAQELKKAFENLGFAVS 119
            ||....:.|...|   |......||:.||.|:|.|:  .:.:|.||..|...|...|..:|:.|
Worm   219 FVDAPTISRVFDEKTMYRNFSSPRGMCLIINNEHFE--QMPTRNGTKADKDNLTNLFRCMGYTV- 280

  Fly   120 VHKD--------CKLRDILKHVGKAAELDHTDNDCLAVAILSHGEHGYLY-AKDTQYKLDNIWHY 175
            :.||        ..:||..||        .:..|...:.||||||...:. ..|.......|:..
Worm   281 ICKDNLTGRGMLLTIRDFAKH--------ESHGDSAILVILSHGEENVIIGVDDIPISTHEIYDL 337

  Fly   176 FTATFCPSLAGKPKLFFIQACQGDRLDGGIT-----------LEKGVTETDGE------------ 217
            ..|...|.||.|||:.|:|||:|:|.|.|..           |.:|....||.
Worm   338 LNAANAPRLANKPKIVFVQACRGERRDNGFPVLDSVDGVPAFLRRGWDNRDGPLFNFLGCVRPQV 402

  Fly   218 SSTSYKIPIHADFLFSYSTIPGYFSWRNINNGSWYMQSLIRELNANGKKYDLLTLLTFVNQRVAL 282
            .....|.|..||.|.:|:|...|.||||...|||::|::....:.:.|..|::.|||.||::||.
Worm   403 QQVWRKKPSQADILIAYATTAQYVSWRNSARGSWFIQAVCEVFSTHAKDMDVVELLTEVNKKVAC 467

  Fly   283 DFESNVPATPMMDRQKQIPCLTSMLTRILRF 313
            .|:::..:..:    ||:|.:||.|.:...|
Worm   468 GFQTSQGSNIL----KQMPEMTSRLLKKFYF 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dcp-1	NP_476974.1	CASc	71..313	CDD:214521	82/273 (30%)
ced-3	NP_001255708.1	CARD	2..90	CDD:128424
ced-3	NP_001255708.1	CASc	235..496	CDD:214521	83/275 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162598
Domainoid	1	1.000	130	1.000	Domainoid score	I3239
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	132	1.000	Inparanoid score	I3180
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000242
OrthoInspector	1	1.000	-	-		mtm4766
orthoMCL	1	0.900	-	-		OOG6_103710
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3066
SonicParanoid	1	1.000	-	-		X460
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.820