DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dcp-1 and Cflar

DIOPT Version :9

Sequence 1:	NP_476974.1	Gene:	Dcp-1 / 37729	FlyBaseID:	FBgn0010501	Length:	323	Species:	Drosophila melanogaster
Sequence 2:	NP_001276633.1	Gene:	Cflar / 12633	MGIID:	1336166	Length:	481	Species:	Mus musculus

Alignment Length:	227	Identity:	63/227 - (27%)
Similarity:	97/227 - (42%)	Gaps:	32/227 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 ARMPVERYASEYNMSHKHRGVALIFNHEFFDIPSLKSRTGTNVDAQELKKAFENLGFAVSVHKDC 124
            |.:|.......|.|..|..|:.||.:             ....|.:.|::.|.:||:.:.:....
Mouse   235 AFLPPHIREETYRMQSKPLGICLIID-------------CIGNDTKYLQETFTSLGYHIQLFLFP 286

  Fly   125 KLRDILKHVGKAAEL-DHTDNDCLAVAILSHGEHGYLYAKD---TQYKLDNIWHYFTATFCPSLA 185
            |..||.:.|.:.|.: .|.|.|..|..::|.|....:..:|   :.:.||::.:.||...||||.
Mouse   287 KSHDITQIVRRYASMAQHQDYDSFACVLVSLGGSQSMMGRDQVHSGFSLDHVKNMFTGDTCPSLR 351

  Fly   186 GKPKLFFIQACQGDRLDGGITLEKGVTETDGESSTSYKI----PIH------ADFLFSYSTIPGY 240
            |||||||||..:    ..|..||....|.||.|..:...    |.|      ||..:|..|....
Mouse   352 GKPKLFFIQNYE----SLGSQLEDSSLEVDGPSIKNVDSKPLQPRHCTTHPEADIFWSLCTADVS 412

  Fly   241 FSWRNINNGSWYMQSLIRELNANGKKYDLLTL 272
            ...:..::.|.|:|.|.::|. .|::..|:.|
Mouse   413 HLEKPSSSSSVYLQKLSQQLK-QGRRRPLVDL 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dcp-1	NP_476974.1	CASc	71..313	CDD:214521	61/216 (28%)
Cflar	NP_001276633.1	Interaction with CASP8 propeptide. /evidence=ECO:0000250\|UniProtKB:O15519	6..307		19/84 (23%)
		Interaction with FADD. /evidence=ECO:0000250\|UniProtKB:O15519	6..229
		Interaction with CASP8. /evidence=ECO:0000250\|UniProtKB:O15519	6..200
		DED_c-FLIP_r1	6..85	CDD:260044
		DED_c-FLIP_r2	96..176	CDD:260046
		Interaction with TRAF1 and TRAF2. /evidence=ECO:0000250\|UniProtKB:O15519	197..481		63/227 (28%)
		Interaction with CASP3. /evidence=ECO:0000250\|UniProtKB:O15519	197..436		60/218 (28%)
		Interaction with CASP8 subunits p18 and p10. /evidence=ECO:0000250\|UniProtKB:O15519	219..481		63/227 (28%)
		CASc	246..480	CDD:214521	61/216 (28%)
		Caspase	265..360		32/94 (34%)
		Interaction with CASP8. /evidence=ECO:0000250\|UniProtKB:O15519	372..481		18/73 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810