DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33964 and mettl25

DIOPT Version :9

Sequence 1:	NP_001033941.1	Gene:	CG33964 / 3772719	FlyBaseID:	FBgn0053964	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_001038522.1	Gene:	mettl25 / 678519	ZFINID:	ZDB-GENE-041210-90	Length:	590	Species:	Danio rerio

Alignment Length:	606	Identity:	171/606 - (28%)
Similarity:	267/606 - (44%)	Gaps:	144/606 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VVQLQRRLDGLLAFLNPHWDFVNCHMVNYLTDQHWDGFLS---ETLKSEIAGKEDVALAIED--- 64
            :|.:::::|.:..||:......|.|.|::.|...|..|:|   |.:...|:..:|...|:|:
Zfish     9 IVAVKKKIDEVKHFLSISLSISNAHTVDFYTRGVWSTFISVSPEDVLCAISSTQDSTGALEEKEN 73

  Fly    65 -LFWKTDESERFPAWREFLGKSKQERLSLHPKL--LTSVEELIE-----------GQGNSTQLSI 115
             .|...:.|::.......|..:|...|   |.|  ...:|||:.           ||.::..|:.
Zfish    74 TTFGFCNASKKLLDISALLRAAKAHCL---PGLGVCMQLEELMHNLRLMCGDTAAGQSSNKVLAP 135

  Fly   116 REFMSAKKCHEVDLTAVLVDQLVKNSGQDCF----IVDAGDGKGYLSSRLALQYGHRVLGIDANA 176
            .|||:.||.|||...:.:|..|.|     |.    ::|.|.|||||.|.|:::|..:|.|||::.
Zfish   136 DEFMNWKKAHEVQSMSEVVASLAK-----CCRVKQVIDVGSGKGYLCSYLSMRYNLQVFGIDSST 195

  Fly   177 ANTENALNRNRKLQR-------------------------------AWNGLTER-AELQVQG--- 206
            .||..|..|||||::                               :.|.:|:: .|.|.:.
Zfish   196 TNTHGAQERNRKLKKFSKAYQQHRFIENNCVQSNDESREHYNESDGSKNCITKQGVEAQTESSAL 260

  Fly   207 ---------------------------------------------ITP-----------KRRSKK 215
                                                         :.|           ||.:.:
Zfish   261 SQQVTRDLLASNNAAECPLDPSDSDSGSSFLSLLALDVIEDVSLRVHPSKLSAEERERRKRENLE 325

  Fly   216 SPARESTKSAPALENYKTTAKFITTELNFGALLAENFTQFRPEDSPNICLTGLHTCGNLAATCLQ 280
            ..|||..:.......:.....::|.|.....|:.|         ..|..|.||||||:||::.|:
Zfish   326 RKAREGKRKDSNSSLFSPLTSYVTAETELKTLITE---------LENAVLVGLHTCGDLASSSLR 381

  Fly   281 VFHAQTDCRLLCNVGCCYHLLRERYSQQEFFGNKSLMELQTD--YGFPLSQYLRERQVRMGRNAR 343
            :|.|:.:.|.:|:||||||||.|.:.|..       ....:|  .|||:||||:::....|||||
Zfish   382 MFRAKQELRAVCSVGCCYHLLSEEFDQDR-------PGCTSDGVCGFPMSQYLKDQACFCGRNAR 439

  Fly   344 MLAAQSIERTLDTKELPNVTLYYRALLEILVCRHAPELKNELQVGKV-RKFESFEEYIQKCATKL 407
            |.|..::||......||..:|:|||:|.:::..|....|:|.:||.| .|..||.:|:::...||
Zfish   440 MSACLALERVSAGGGLPMESLFYRAVLHVILQDHYDCFKSEKRVGNVYSKATSFADYVRRALRKL 504

  Fly   408 DAPWLAAVEKEELQSLLQEYAVHKYFLDLFYLLRMSFAPVLESLILLDRLLYLKEL-GYERSYLI 471
            |.. .:.:...::||....|......:..|.:|:::.||.:|.|||||||.||||. ....:.|:
Zfish   505 DLD-ESKLSDGDIQSYHDRYTPRMNEMVAFNMLKVTLAPCIEGLILLDRLCYLKEQENVSHAALV 568

  Fly   472 DLFDPVISPRHFAIVSIKQQT 492
            .||||:.|||.:|:|.||:.|
Zfish   569 QLFDPLQSPRCYAVVGIKKST 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33964	NP_001033941.1	Methyltransf_32	122..304	CDD:290402	68/276 (25%)
mettl25	NP_001038522.1	AdoMet_MTases	142..405	CDD:302624	68/276 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	122	1.000	Domainoid score	I5618
eggNOG	1	0.900	-	-		E1_KOG2651
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32774
Inparanoid	1	1.050	242	1.000	Inparanoid score	I3294
OMA	1	1.010	-	-		QHG55767
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008296
OrthoInspector	1	1.000	-	-		oto41375
orthoMCL	1	0.900	-	-		OOG6_106363
Panther	1	1.100	-	-	LDO	PTHR12496
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5160
SonicParanoid	1	1.000	-	-		X6279
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.860