Protein Alignment CG33964 and METTL25B

DIOPT Version :9

• Sequence 1: NP_001033941.1
• Gene: CG33964 / 3772719
• FlyBaseID: FBgn0053964
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_057081.3
• Gene: METTL25B / 51093
• HGNCID: 24273
• Length: 475
• Species: Homo sapiens
• Alignment Length: 544
• Identity: 146/544 - (26%)
• Similarity: 220/544 - (40%)
• Gaps: 137/544 - (25%)

  Fly     1 MSKVGVVQLQRRLDGLLAFLNPHWDFVNCHMVNYLTDQHWDGFLSETLKSEIAGKEDVALAIEDL 65
            :|..|..||...|..:||.   :...::.:::.:.||..||     ||..
Human     9 LSHEGRKQLAVNLTRVLAL---YRSILDAYIIEFFTDNLWD-----TLPC--------------- 50

  Fly    66 FWKTDESERFPAWREFLGKSKQERL-----------------SLHPKLLTSVE------------ 101
                       :|:|.|...|..:|                 |:.|..|.:::
Human    51 -----------SWQEALDGLKPPQLATMLLGMPGEGEVVRYRSVWPLTLLALKSTACALAFTRMP 104

  Fly   102 ------ELIEGQGNSTQLS--IREFMSAKKCHEVDLTAVLVDQLVKNSGQDCF-IVDAGDGKGYL 157
                  |.:|....|::|:  .|:.:..||.||:.....||.:|...:|  |. :||.|.|:|:|
Human   105 GFQTPSEFLENPSQSSRLTAPFRKHVRPKKQHEIRRLGELVKKLSDFTG--CTQVVDVGSGQGHL 167

  Fly   158 SSRLALQYGHRVLGIDANAANTENALNRNRKLQRAWNGLTERAELQVQGITPKRRSKKSPAREST 222
            |..:||..|..|..|:.:....|.|...:::|.:|.....:|....||  |..|.|.....|...
Human   168 SRFMALGLGLMVKSIEGDQRLVERAQRLDQELLQALEKEEKRNPQVVQ--TSPRHSPHHVVRWVD 230

  Fly   223 KSAPALENYKTTAKFITTELNFGALLAENFTQFRPEDSPNICLTGLHTCGNLAATCLQVFHAQTD 287
            .:|            :..||   .|..||..|.|    ..:.|||||.||:|:...|:.|....:
Human   231 PTA------------LCEEL---LLPLENPCQGR----ARLLLTGLHACGDLSVALLRHFSCCPE 276

  Fly   288 CRLLCNVGCCYHLLRERYSQQEFFGNKSLMELQTDYGFPLSQYLR-----ERQVRMGRNARMLAA 347
            ...|.:|||||                  |:|....|:||||::.     |...|:...|.....
Human   277 VVALASVGCCY------------------MKLSDPGGYPLSQWVAGLPGYELPYRLREGACHALE 323

  Fly   348 QSIERTLDTKELPNV-TLYYRALLEILVCRHAPELKNELQVGKVRKFE-SFEEYIQKCATK--LD 408
            :..||.  .|..|.: |..|||.||.::.|..|||:.....|..|..| ..|||:|:...:  ||
Human   324 EYAERL--QKAGPGLRTHCYRAALETVIRRARPELRRPGVQGIPRVHELKIEEYVQRGLQRVGLD 386

  Fly   409 APW---LAAVEKEELQSLLQEYAVHKYFLDLFYLLRMSFAPVLESLILLDRLLYLKELGYERSYL 470
            ...   |||         ||.:...:..:..|:.|.:..||::|:||||||||||:|.|: .:.|
Human   387 PQLPLNLAA---------LQAHVAQENRVVAFFSLALLLAPLVETLILLDRLLYLQEQGF-HAEL 441

  Fly   471 IDLFDPVISPRHFAIVSIKQQTQQ 494
            :.:|.|.:|||:..:|:.|....|
Human   442 LPIFSPELSPRNLVLVATKMPLGQ 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33964	NP_001033941.1	Methyltransf_32	122..304	CDD:290402	56/182 (31%)
METTL25B	NP_057081.3	Methyltransf_32	133..293	CDD:290402	58/200 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2651
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5160
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840