DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wmd and slmb

DIOPT Version :9

Sequence 1:	NP_001097436.1	Gene:	wmd / 37727	FlyBaseID:	FBgn0034876	Length:	328	Species:	Drosophila melanogaster
Sequence 2:	NP_001262802.1	Gene:	slmb / 42504	FlyBaseID:	FBgn0283468	Length:	597	Species:	Drosophila melanogaster

Alignment Length:	321	Identity:	74/321 - (23%)
Similarity:	139/321 - (43%)	Gaps:	41/321 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LRQIPLTC-SGHTRPVVHLDFSDICDAGYFLISACKDGSPMLRHGDTGD--WVGTFEGHKGAVWN 67
            ||:|  .| |.:::.|..|.:.|    |. ::|..:|.:  ::..|..|  .|.|..||.|:|
  Fly   200 LRRI--NCRSENSKGVYCLQYDD----GK-IVSGLRDNT--IKIWDRTDLQCVKTLMGHTGSV-- 253

  Fly    68 ATLNRNATLAASGAADFTGKVWNAVTGAEIHS-FQHKHIVKSVAFDRDSENIVTGSNEKLVRVFN 131
            ..|..:..:..||::|.|.:||:..||..::: ..|...|..:.|:...  :||.|.::.:.|::
  Fly   254 LCLQYDDKVIISGSSDSTVRVWDVNTGEMVNTLIHHCEAVLHLRFNNGM--MVTCSKDRSIAVWD 316

  Fly   132 LEQPE--AQPEEYAGHTGAIKRALFCRGDKCIISAAEDKTVRLWDRMTGIEVQRLQFNSNPNSLE 194
            :..|.  .......||..|:....|  .:|.|:||:.|:|:::|...:...|:.|..:....:..
  Fly   317 MTSPSEITLRRVLVGHRAAVNVVDF--DEKYIVSASGDRTIKVWSTSSCEFVRTLNGHKRGIACL 379

  Fly   195 ISSDNHILTISHGSSISFWEIDTLKKLKEVKVPTNVASASLHPDKHVFVCGGEDFKMYKFDYITG 259
            ...|..:::.|..:||..|:|:....|:.::....:........|.: |.|..|.|:..:|.:..
  Fly   380 QYRDRLVVSGSSDNSIRLWDIECGACLRVLEGHEELVRCIRFDTKRI-VSGAYDGKIKVWDLVAA 443

  Fly   260 NE---------IESFKGHFGPVHSVKFSPDGELYASGSEDGTLRLW--------QTTVGKT 303
            .:         :.:...|.|.|..::|  |.....|.|.|.|:.:|        :...|:|
  Fly   444 LDPRAASNTLCLNTLVEHTGRVFRLQF--DEFQIVSSSHDDTILIWDFLNFTPNENKTGRT 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wmd	NP_001097436.1	WD40	12..297	CDD:238121	69/307 (22%)
		WD40 repeat	25..60	CDD:293791	8/36 (22%)
		WD40 repeat	66..101	CDD:293791	9/35 (26%)
		WD40 repeat	108..144	CDD:293791	6/37 (16%)
		WD40 repeat	150..186	CDD:293791	10/35 (29%)
		WD40 repeat	190..225	CDD:293791	7/34 (21%)
		WD40 repeat	231..266	CDD:293791	6/43 (14%)
		WD40 repeat	272..308	CDD:293791	10/40 (25%)
slmb	NP_001262802.1	Beta-TrCP_D	47..85	CDD:288940
		F-box-like	89..136	CDD:289689
		WD40	<192..495	CDD:225201	72/312 (23%)
		WD40	210..488	CDD:238121	66/293 (23%)
		WD40 repeat	213..248	CDD:293791	10/41 (24%)
		WD40 repeat	254..288	CDD:293791	9/33 (27%)
		WD40 repeat	293..330	CDD:293791	7/38 (18%)
		WD40 repeat	337..370	CDD:293791	9/34 (26%)
		WD40 repeat	376..410	CDD:293791	7/33 (21%)
		WD40 repeat	416..459	CDD:293791	6/43 (14%)
		WD40 repeat	465..487	CDD:293791	7/23 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR44156
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100