DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Menl-2 and NADP-ME4

DIOPT Version :9

Sequence 1:	NP_001027424.2	Gene:	Menl-2 / 3772692	FlyBaseID:	FBgn0029153	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_178093.1	Gene:	NADP-ME4 / 844314	AraportID:	AT1G79750	Length:	646	Species:	Arabidopsis thaliana

Alignment Length:	529	Identity:	206/529 - (38%)
Similarity:	317/529 - (59%)	Gaps:	2/529 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 YNKGLAFTIKERQRLGIMGLMPCSVRSMDDQMNAALANFEARPTDIARFTYLSAVHHRHRRLYYR 111
            :||||||:.:||....:.||:|.:|.|.|.|:...:.........:.::..:..:...:.||:|:
plant   116 HNKGLAFSHRERDAHYLRGLLPPTVISQDLQVKKIMHTLRQYQVPLQKYMAMMDLQETNERLFYK 180

  Fly   112 FIKENIEKSLPIVYTPTVGDVVATYGLNFQQAISLFISIHDKGHIRDLMHNWVDEGVKAICVTDG 176
            .:.:::|:.||::||||||:....||..|.:...||||:.:||.|.:::.||.::.::.|.||||
plant   181 LLIDHVEELLPVIYTPTVGEACQKYGSIFLRPQGLFISLKEKGKIHEVLRNWPEKNIQVIVVTDG 245

  Fly   177 GRVLGLGDMGANAMGISLGKMILYTALGSIPPSTLMPVCLDVGTDNQALLQDPLYVGARIPRVKG 241
            .|:|||||:|...|||.:||:.||||||.:.||..:||.:||||:|:.||.|..|:|.|..|..|
plant   246 ERILGLGDLGCQGMGIPVGKLSLYTALGGVRPSACLPVTIDVGTNNEKLLNDEFYIGLRQRRATG 310

  Fly   242 PEYDELVDEFMESAVKCFGNNTFIHFEDFATPNALKFLEKYQYKYCCFNDDIQGTGATGLAAFIN 306
            .||.||:.|||.:..:.:|....|.|||||..||...|.||...:..||||||||.:..||..|.
plant   311 EEYSELMHEFMTAVKQNYGEKVVIQFEDFANHNAFDLLAKYGTTHLVFNDDIQGTASVVLAGLIA 375

  Fly   307 VERITGRKLEDTVFLFVGAGSAALGIANMLAMELEVRG-IPAEEATKNIYLMDVNG-ILTPESPN 369
            ..|..|..|.|..|||:|||.|..|||.::|:|:..:. ||.|||.|||:|:|..| |::....:
plant   376 ALRFVGGSLSDHRFLFLGAGEAGTGIAELIALEISKKSHIPLEEARKNIWLVDSKGLIVSSRKES 440

  Fly   370 PPEMGKIFIKSMEPMKDMMAVLKKLKPSVLVGATGVGGIFNEEVLKTMAKNHERPAVFPLSNPTA 434
            .....|.:....||:::::..:|.:||:||:|.:|||..|.::|::||||.:|:|.:..|||||:
plant   441 IQHFKKPWAHDHEPIRELVDAVKAIKPTVLIGTSGVGQTFTQDVVETMAKLNEKPIILSLSNPTS 505

  Fly   435 NSECTAEQAFTHTEGRVLFGSGSPFPPVVINGKRYRPAQANNCLTFPGIALAAITAKARYLPNEV 499
            .||||||:|:|.::||.:|.|||||.||...||.:.|.||||...|||..|..|.:....:.:::
plant   506 QSECTAEEAYTWSQGRAIFASGSPFAPVEYEGKTFVPGQANNAYIFPGFGLGLIMSGTIRVHDDM 570

  Fly   500 FSVVSHELARNTPQELLDEGTLFPPIKDAHNVAFNVGVAMTQYLIDNDLSNVYPKPDDICEFVKR 564
            ....|..||....:|..::|.::||.::...::..:...:.....:..|:...|:|.::.:..:.
plant   571 LLAASEALAEELMEEHYEKGMIYPPFRNIRKISARIAAKVAAKAYELGLATRLPQPKELEQCAES 635

  Fly   565 SLYKFDYRN 573
            |:|...||:
plant   636 SMYSPSYRS 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Menl-2	NP_001027424.2	PLN03129	8..573	CDD:215594	205/527 (39%)
		malic	102..283	CDD:278802	82/180 (46%)
		NADB_Rossmann	293..567	CDD:304358	101/275 (37%)
NADP-ME4	NP_178093.1	PLN03129	67..646	CDD:215594	206/529 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60768
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	1	1.100	-	-	O	PTHR23406
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.780