Protein Alignment Menl-2 and me3

DIOPT Version :9

• Sequence 1: NP_001027424.2
• Gene: Menl-2 / 3772692
• FlyBaseID: FBgn0029153
• Length: 600
• Species: Drosophila melanogaster
• Sequence 2: NP_001082825.1
• Gene: me3 / 492719
• ZFINID: ZDB-GENE-041111-294
• Length: 603
• Species: Danio rerio
• Alignment Length: 545
• Identity: 230/545 - (42%)
• Similarity: 342/545 - (62%)
• Gaps: 1/545 - (0%)

  Fly    39 WHVVMNGKYNKGLAFTIKERQRLGIMGLMPCSVRSMDDQMNAALANFEARPTDIARFTYLSAVHH 103
            :.:..|...|||:|||::||.:|||.||:|....|.|.|:...:.::|.|...:.::..|..:..
Zfish    50 YDITRNPHLNKGMAFTLEERLQLGIHGLLPPCFLSQDVQVLRVMKSYETRSNPLDKYILLMTLQD 114

  Fly   104 RHRRLYYRFIKENIEKSLPIVYTPTVGDVVATYGLNFQQAISLFISIHDKGHIRDLMHNWVDEGV 168
            |:.:|:||.:..:||:.:|||||||||.....|||.|::...|||:|||||||..::::|.:|.:
Zfish   115 RNEKLFYRVLTSDIEEFMPIVYTPTVGLACQQYGLAFRRPRGLFITIHDKGHIATMLNSWPEEDI 179

  Fly   169 KAICVTDGGRVLGLGDMGANAMGISLGKMILYTALGSIPPSTLMPVCLDVGTDNQALLQDPLYVG 233
            |||.||||.|:|||||:|...|||.:||:.||||.|.:||...:||.||||||||.||.||||:|
Zfish   180 KAIVVTDGERILGLGDLGGYGMGIPVGKLALYTACGGVPPQQCLPVLLDVGTDNQTLLDDPLYIG 244

  Fly   234 ARIPRVKGPEYDELVDEFMESAVKCFGNNTFIHFEDFATPNALKFLEKYQYKYCCFNDDIQGTGA 298
            .:..||:|.|||:|:||||::....:|.|..|.|||||..||.:.|.||:.:||.||||||||.:
Zfish   245 LKHKRVRGKEYDDLIDEFMQAVTDKYGMNCLIQFEDFANSNAFRILNKYRNRYCTFNDDIQGTAS 309

  Fly   299 TGLAAFINVERITGRKLEDTVFLFVGAGSAALGIANMLAMELEVRGIPAEEATKNIYLMDVNGIL 363
            ..:|..:...:||..||.|..|:|.|||.||||||::|.|.:...|||..||.:.|:::|..|::
Zfish   310 VAVAGILAALKITKNKLSDHKFVFQGAGEAALGIAHLLIMAMAKEGIPHAEAAQRIWMVDSKGLI 374

  Fly   364 TPESPNPPEMGKIFIKSMEPMKDMMAVLKKLKPSVLVGATGVGGIFNEEVLKTMAKNHERPAVFP 428
            .....:.....:.|......:|.:..|::.:||:.::|...:||.|.|:::|.||.|:|||.:|.
Zfish   375 VKGRSHLNHEKEEFAHDHPHIKTLEEVVETIKPTAIIGVAAIGGAFTEKIIKNMAANNERPIIFA 439

  Fly   429 LSNPTANSECTAEQAFTHTEGRVLFGSGSPFPPVVI-NGKRYRPAQANNCLTFPGIALAAITAKA 492
            |||||:.:||||||.:|.||||.:|.|||||..|.: :|:.:.|.|.||...|||:||..|....
Zfish   440 LSNPTSKAECTAEQCYTLTEGRGIFASGSPFKKVTLADGRSFYPGQGNNAYVFPGVALGVIACGV 504

  Fly   493 RYLPNEVFSVVSHELARNTPQELLDEGTLFPPIKDAHNVAFNVGVAMTQYLIDNDLSNVYPKPDD 557
            |::.:::|...:..::....:|.|.||.|:||:|....|:|.:.|.:..:.....:::.||:|.|
Zfish   505 RHISDDIFLTTAEAISEMVTEEHLAEGRLYPPLKTIREVSFKIAVKIVDHAYKQGIASWYPEPKD 569

  Fly   558 ICEFVKRSLYKFDYRNSLPTTWDYP 582
            ...|:...:|..||.:....::.:|
Zfish   570 KEAFILSHVYNSDYDSFTLDSYSWP 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Menl-2	NP_001027424.2	PLN03129	8..573	CDD:215594	229/534 (43%)
		malic	102..283	CDD:278802	97/180 (54%)
		NADB_Rossmann	293..567	CDD:304358	101/274 (37%)
me3	NP_001082825.1	PLN03129	47..587	CDD:215594	229/536 (43%)
		malic	113..294	CDD:278802	97/180 (54%)
		NAD_bind_1_malic_enz	304..580	CDD:133454	101/275 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595264
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60768
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	1	1.100	-	-	O	PTHR23406
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.710