DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Menl-2 and Men

DIOPT Version :9

Sequence 1:	NP_001027424.2	Gene:	Menl-2 / 3772692	FlyBaseID:	FBgn0029153	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_524880.2	Gene:	Men / 47173	FlyBaseID:	FBgn0002719	Length:	763	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	234/540 - (43%)
Similarity:	342/540 - (63%)	Gaps:	2/540 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 VMNGKYNKGLAFTIKERQRLGIMGLMPCSVRSMDDQMNAALANFEARPTDIARFTYLSAVHHRHR 106
            :::.:|:||||||.:|||:|||.|::|..||...:|:....|.......|:.::.||.::..|:.
  Fly   222 LLDKRYSKGLAFTHEERQQLGIHGMLPYVVREPSEQVEHCRALLARLDQDLDKYMYLISLSERNE 286

  Fly   107 RLYYRFIKENIEKSLPIVYTPTVGDVVATYGLNFQQAISLFISIHDKGHIRDLMHNWVDEGVKAI 171
            ||:|..:..:|...:|:|||||||.....|.|..|.|..:||||.|||||.|::.||.:..|:||
  Fly   287 RLFYNVLSSDIAYMMPLVYTPTVGLACQRYSLIHQNAKGMFISIKDKGHIYDVLKNWPETDVRAI 351

  Fly   172 CVTDGGRVLGLGDMGANAMGISLGKMILYTALGSIPPSTLMPVCLDVGTDNQALLQDPLYVGARI 236
            .||||.|:|||||:|||.|||.:||:.|||||..|.||..:|:.|||||:.:::|:||||:|.|.
  Fly   352 VVTDGERILGLGDLGANGMGIPVGKLSLYTALAGIKPSQCLPITLDVGTNTESILEDPLYIGLRE 416

  Fly   237 PRVKGPEYDELVDEFMESAVKCFGNNTFIHFEDFATPNALKFLEKYQYKYCCFNDDIQGTGATGL 301
            .|..|..|||.:||||.:.|:.||.|..|.|||||..||.:.|.||:..:|.||||||||.:..:
  Fly   417 RRATGDLYDEFIDEFMHACVRRFGQNCLIQFEDFANANAFRLLSKYRDSFCTFNDDIQGTASVAV 481

  Fly   302 AAFINVERITGRKLEDTVFLFVGAGSAALGIANMLAMELEVRGIPAEEATKNIYLMDVNGILTPE 366
            |..:...:|...:|:|...||:|||.|||||||:..|.::|.|:..|||...|:::|..|::|.:
  Fly   482 AGLLASLKIKKTQLKDNTLLFLGAGEAALGIANLCLMAMKVEGLTEEEAKARIWMVDSRGVITRD 546

  Fly   367 SPNP--PEMGKIFIKSMEPMKDMMAVLKKLKPSVLVGATGVGGIFNEEVLKTMAKNHERPAVFPL 429
            .|..  .|....|.:..||:..:...::|::|:||:||...||.||:|:|:.||..:|.|.:|.|
  Fly   547 RPKGGLTEHKLHFAQLHEPIDTLAEAVRKVRPNVLIGAAAQGGAFNQEILELMADINETPIIFAL 611

  Fly   430 SNPTANSECTAEQAFTHTEGRVLFGSGSPFPPVVINGKRYRPAQANNCLTFPGIALAAITAKARY 494
            ||||:.:|||||:|:|:|:||.:|.|||||.||..|.|::.|.|.||...|||:||..:.|....
  Fly   612 SNPTSKAECTAEEAYTYTKGRCIFASGSPFAPVTYNNKKFYPGQGNNSYIFPGVALGVLCAGMLN 676

  Fly   495 LPNEVFSVVSHELARNTPQELLDEGTLFPPIKDAHNVAFNVGVAMTQYLIDNDLSNVYPKPDDIC 559
            :|.:||.|.:..||....::.|.:|:|:||:....:.:..:...:.:|...|.|:.|.|:|.:..
  Fly   677 IPEQVFLVAAERLAELVSKDDLAKGSLYPPLSSIVSCSMAIAERIVEYAYKNGLATVRPEPVNKL 741

  Fly   560 EFVKRSLYKFDYRNSLPTTW 579
            .|:|..:|..||..|:|.|:
  Fly   742 AFIKAQMYDLDYPRSVPATY 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Menl-2	NP_001027424.2	PLN03129	8..573	CDD:215594	231/532 (43%)
		malic	102..283	CDD:278802	94/180 (52%)
		NADB_Rossmann	293..567	CDD:304358	106/275 (39%)
Men	NP_524880.2	PLN03129	213..757	CDD:215594	231/534 (43%)
		malic	282..463	CDD:278802	94/180 (52%)
		NAD_bind_1_malic_enz	473..750	CDD:133454	106/276 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469231
Domainoid	1	1.000	171	1.000	Domainoid score	I157
eggNOG	1	0.900	-	-		E1_COG0281
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	435	1.000	Inparanoid score	I37
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	1	1.000	-	-		otm51392
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	1	1.100	-	-	P	PTHR23406
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X340
	10	9.790