DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Menl-2 and Men-b

DIOPT Version :9

Sequence 1:	NP_001027424.2	Gene:	Menl-2 / 3772692	FlyBaseID:	FBgn0029153	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_001163750.1	Gene:	Men-b / 43936	FlyBaseID:	FBgn0029155	Length:	624	Species:	Drosophila melanogaster

Alignment Length:	573	Identity:	256/573 - (44%)
Similarity:	366/573 - (63%)	Gaps:	21/573 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 VMNGKYNKGLAFTIKERQRLGIMGLMPCSVRSMDDQMNAALANFEARPTDIARFTYLSAVHHRHR 106
            :.:.:.|||||||::|||.|||.||.|...::.::|:.............:.::.|||.::.|:.
  Fly    57 IRDPRLNKGLAFTLEERQTLGIHGLQPARFKTQEEQLQLCKIAVNRYTEPLNKYLYLSDLYDRNE 121

  Fly   107 RLYYRFIKENIEKSLPIVYTPTVGDVVATYGLNFQQAISLFISIHDKGHIRDLMHNWVDEGVKAI 171
            ||::||:.||||..:|||||||||.....:||.:::...|||:.:|:|||.|:|.||.:..|:||
  Fly   122 RLFFRFLSENIEDLMPIVYTPTVGLACQRFGLIYRRPHGLFITYNDRGHIFDVMKNWPEPNVRAI 186

  Fly   172 CVTDGGRVLGLGDMGANAMGISLGKMILYTALGSIPPSTLMPVCLDVGTDNQALLQDPLYVGARI 236
            |||||.|:|||||:||..|||.:||:.|||||..|.|...:|:.:||||:|..||:||||||.|.
  Fly   187 CVTDGERILGLGDLGACGMGIPVGKLALYTALAGIKPHQCLPIVVDVGTNNIDLLEDPLYVGLRQ 251

  Fly   237 PRVKGPEYDELVDEFMESAVKCFGNNTFIHFEDFATPNALKFLEKYQYKYCCFNDDIQGTGATGL 301
            .||.|.||||.:|||||:.|:.:|.||.|.||||...||.:||:||:..||.||||||||.:..:
  Fly   252 KRVVGREYDEFIDEFMEAVVQRYGQNTLIQFEDFGNHNAFRFLDKYRNTYCTFNDDIQGTASVAV 316

  Fly   302 AAFINVERITGRKLEDTVFLFVGAGSAALGIANMLAMELEVRGIPAEEATKNIYLMDVNGILTPE 366
            |.....:||||:..:|..|||.|||.||:|||::....:...|:|.|||...||::|::|:||..
  Fly   317 AGLYASKRITGKSFKDYTFLFAGAGEAAIGIADLTVKAMVQDGVPIEEAYNRIYMVDIDGLLTKS 381

  Fly   367 SPNPPEMGKI------FIKSMEPMKDMMAVLKKLKPSVLVGATGVGGIFNEEVLKTMAKNHERPA 425
            .    ::|.:      :.|.:.||.|:..::..:|||||:||:...|||..|:|:|||.|:|||.
  Fly   382 R----KVGNLDGHKIHYAKDINPMSDLAEIVSTIKPSVLIGASAAAGIFTPEILRTMADNNERPV 442

  Fly   426 VFPLSNPTANSECTAEQAFTHTEGRVLFGSGSPFPPVVINGKRYRPAQANNCLTFPGIALAAITA 490
            ||.|||||:.:|||||.|:.||:.||:|.||||||||.|..|.:.|.|.||...|||:.|..|..
  Fly   443 VFALSNPTSKAECTAEDAYKHTDARVIFSSGSPFPPVQIGDKTFYPGQGNNAYIFPGVGLGVICT 507

  Fly   491 KARYLPNEVFSVVSHELARNTPQELLDEGTLFPPIKDAHNVAFNVGVAMTQYLIDNDLSNVYPKP 555
            ...::|:|:|.:.:.|||.......::.|:|:||:....||:.|:.|.:|:...|..|::.||:|
  Fly   508 GTHHIPDEMFLIAAQELANFVEPSDIERGSLYPPLSSIRNVSMNIAVGVTKCAYDRGLASTYPEP 572

  Fly   556 DDICEFVKRSLYKFDYRNSLPTTWDYPVEP--------PTPKPKTKPKTKPKE 600
            .|..::::..||.|:|.:|:|.:|.:|..|        ||   |...|.|.:|
  Fly   573 QDKRKWLENQLYNFNYESSMPASWVWPRMPYIKTRDLVPT---KLYGKQKSEE 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Menl-2	NP_001027424.2	PLN03129	8..573	CDD:215594	245/536 (46%)
		malic	102..283	CDD:278802	100/180 (56%)
		NADB_Rossmann	293..567	CDD:304358	114/279 (41%)
Men-b	NP_001163750.1	PLN03129	51..590	CDD:215594	245/536 (46%)
		malic	117..298	CDD:278802	100/180 (56%)
		NAD_bind_1_malic_enz	308..585	CDD:133454	115/280 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469225
Domainoid	1	1.000	171	1.000	Domainoid score	I157
eggNOG	1	0.900	-	-		E1_COG0281
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	435	1.000	Inparanoid score	I37
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	1	1.000	-	-		otm51392
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	1	1.100	-	-	P	PTHR23406
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X340
	10	9.790