Protein Alignment Menl-2 and ME2

DIOPT Version :9

• Sequence 1: NP_001027424.2
• Gene: Menl-2 / 3772692
• FlyBaseID: FBgn0029153
• Length: 600
• Species: Drosophila melanogaster
• Sequence 2: NP_002387.1
• Gene: ME2 / 4200
• HGNCID: 6984
• Length: 584
• Species: Homo sapiens
• Alignment Length: 561
• Identity: 230/561 - (40%)
• Similarity: 347/561 - (61%)
• Gaps: 22/561 - (3%)

  Fly    41 VVMNGKYNKGLAFTIKERQRLGIMGLMPCSVRSMDDQMNAALANFEARPTDIARFTYLSAVHHRH 105
            :::|.:.|||:|||::|||.||:.||:|..:.:.|.|......|.:...:.:.::.|:..:..|:
Human    28 LMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYIMGIQERN 92

  Fly   106 RRLYYRFIKENIEKSLPIVYTPTVGDVVATYGLNFQQAISLFISIHDKGHIRDLMHNWVDEGVKA 170
            .:|:||.::::||..:|||||||||...:.||..|::...|||||.|:||:|.::.||.:..|||
Human    93 EKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKA 157

  Fly   171 ICVTDGGRVLGLGDMGANAMGISLGKMILYTALGSIPPSTLMPVCLDVGTDNQALLQDPLYVGAR 235
            :.||||.|:|||||:|...|||.:||:.||||...|.|...:|||:||||||.|||:||.|:|..
Human   158 VVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPFYMGLY 222

  Fly   236 IPRVKGPEYDELVDEFMESAVKCFGNNTFIHFEDFATPNALKFLEKYQYKYCCFNDDIQGTGATG 300
            ..|.:..:||:|:||||::....:|.||.|.||||...||.:||.||:.|||.||||||||.|..
Human   223 QKRDRTQQYDDLIDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLRKYREKYCTFNDDIQGTAAVA 287

  Fly   301 LAAFINVERITGRKLEDTVFLFVGAGSAALGIANMLAMELEVRGIPAEEATKNIYLMDVNGILT- 364
            ||..:..:::..:.:.:...||:|||.|||||||::.|.:...|:..:||.|.|::.|..|:|.
Human   288 LAGLLAAQKVISKPISEHKILFLGAGEAALGIANLIVMSMVENGLSEQEAQKKIWMFDKYGLLVK 352

  Fly   365 -----------PESPNPPEMGKIFIKSMEPMKDMMAVLKKLKPSVLVGATGVGGIFNEEVLKTMA 418
                       |.:.:.||      ...:..:|.:.:   ||||.::|..|.|.:|..:|::.||
Human   353 GRKAKIDSYQEPFTHSAPE------SIPDTFEDAVNI---LKPSTIIGVAGAGRLFTPDVIRAMA 408

  Fly   419 KNHERPAVFPLSNPTANSECTAEQAFTHTEGRVLFGSGSPFPPV-VINGKRYRPAQANNCLTFPG 482
            ..:|||.:|.||||||.:|||||:|:|.||||.||.|||||.|| :.:|:.:.|.|.||...|||
Human   409 SINERPVIFALSNPTAQAECTAEEAYTLTEGRCLFASGSPFGPVKLTDGRVFTPGQGNNVYIFPG 473

  Fly   483 IALAAITAKARYLPNEVFSVVSHELARNTPQELLDEGTLFPPIKDAHNVAFNVGVAMTQYLIDND 547
            :|||.|....|::.:.||...:..|......|.|.:|.|:||:.:...|:.|:.:.:|:||..|.
Human   474 VALAVILCNTRHISDSVFLEAAKALTSQLTDEELAQGRLYPPLANIQEVSINIAIKVTEYLYANK 538

  Fly   548 LSNVYPKPDDICEFVKRSLYKFDYRNSLPTTWDYPVEPPTP 588
            ::..||:|:|..::||...::.:|.:.||..:::|....:|
Human   539 MAFRYPEPEDKAKYVKERTWRSEYDSLLPDVYEWPESASSP 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Menl-2	NP_001027424.2	PLN03129	8..573	CDD:215594	226/544 (42%)
		malic	102..283	CDD:278802	91/180 (51%)
		NADB_Rossmann	293..567	CDD:304358	107/286 (37%)
ME2	NP_002387.1	PLN03129	28..566	CDD:215594	226/546 (41%)
		malic	89..270	CDD:278802	91/180 (51%)
		NAD_bind_1_malic_enz	280..558	CDD:133454	107/286 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159165
Domainoid	1	1.000	46	1.000	Domainoid score	I12124
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60768
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.610