DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Menl-2 and ME1

DIOPT Version :9

Sequence 1:	NP_001027424.2	Gene:	Menl-2 / 3772692	FlyBaseID:	FBgn0029153	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_002386.1	Gene:	ME1 / 4199	HGNCID:	6983	Length:	572	Species:	Homo sapiens

Alignment Length:	551	Identity:	238/551 - (43%)
Similarity:	345/551 - (62%)	Gaps:	3/551 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 NGKYNKGLAFTIKERQRLGIMGLMPCSVRSMDDQMNAALANFEARPTDIARFTYLSAVHHRHRRL 108
            |...||.||||::|||:|.|.||:|.|..|.:.|:...:.|||...:|..|:..|..:..|:.:|
Human    21 NPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVKNFEHLNSDFDRYLLLMDLQDRNEKL 85

  Fly   109 YYRFIKENIEKSLPIVYTPTVGDVVATYGLNFQQAISLFISIHDKGHIRDLMHNWVDEGVKAICV 173
            :||.:..:|||.:|||||||||.....|.|.|::...|||:|||:|||..:::.|.::.:|||.|
Human    86 FYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKPRGLFITIHDRGHIASVLNAWPEDVIKAIVV 150

  Fly   174 TDGGRVLGLGDMGANAMGISLGKMILYTALGSIPPSTLMPVCLDVGTDNQALLQDPLYVGARIPR 238
            |||.|:|||||:|.|.|||.:||:.||||.|.:.|...:||.|||||:|:.||:||||:|.|..|
Human   151 TDGERILGLGDLGCNGMGIPVGKLALYTACGGMNPQECLPVILDVGTENEELLKDPLYIGLRQRR 215

  Fly   239 VKGPEYDELVDEFMESAVKCFGNNTFIHFEDFATPNALKFLEKYQYKYCCFNDDIQGTGATGLAA 303
            |:|.|||:.:|||||:....:|.|..|.|||||..||.:.|.||:.:||.||||||||.:..:|.
Human   216 VRGSEYDDFLDEFMEAVSSKYGMNCLIQFEDFANVNAFRLLNKYRNQYCTFNDDIQGTASVAVAG 280

  Fly   304 FINVERITGRKLEDTVFLFVGAGSAALGIANMLAMELEVRGIPAEEATKNIYLMDVNGILTPESP 368
            .:...|||..||.|...||.|||.||||||:::.|.||..|:|.|:|.|.|:|:|..|::.....
Human   281 LLAALRITKNKLSDQTILFQGAGEAALGIAHLIVMALEKEGLPKEKAIKKIWLVDSKGLIVKGRA 345

  Fly   369 NPPEMGKIFIKSMEPMKDMMAVLKKLKPSVLVGATGVGGIFNEEVLKTMAKNHERPAVFPLSNPT 433
            :..:..:.|....|.||::.|:::::||:.|:|...:||.|:|::||.||..:|||.:|.|||||
Human   346 SLTQEKEKFAHEHEEMKNLEAIVQEIKPTALIGVAAIGGAFSEQILKDMAAFNERPIIFALSNPT 410

  Fly   434 ANSECTAEQAFTHTEGRVLFGSGSPFPPVVI-NGKRYRPAQANNCLTFPGIALAAITAKARYLPN 497
            :.:||:|||.:..|:||.:|.|||||.||.: ||:...|.|.||...|||:||..:....|.:.:
Human   411 SKAECSAEQCYKITKGRAIFASGSPFDPVTLPNGQTLYPGQGNNSYVFPGVALGVVACGLRQITD 475

  Fly   498 EVFSVVSHELARNTPQELLDEGTLFPPIKDAHNVAFNVGVAMTQYLIDNDLSNVYPKPDDICEFV 562
            .:|...:..:|:....:.|:||.|:||:....:|:..:...:.:.......:.|||:|.:...||
Human   476 NIFLTTAEVIAQQVSDKHLEEGRLYPPLNTIRDVSLKIAEKIVKDAYQEKTATVYPEPQNKEAFV 540

  Fly   563 KRSLYKFDYRNSLPTTWDYPVEPPTPKPKTK 593
            :..:|..||...||..:.:|.|  ..|.:||
Human   541 RSQMYSTDYDQILPDCYSWPEE--VQKIQTK 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Menl-2	NP_001027424.2	PLN03129	8..573	CDD:215594	231/529 (44%)
		malic	102..283	CDD:278802	94/180 (52%)
		NADB_Rossmann	293..567	CDD:304358	103/274 (38%)
ME1	NP_002386.1	PLN03129	11..551	CDD:215594	231/529 (44%)
		malic	79..260	CDD:278802	94/180 (52%)
		NAD_bind_1_malic_enz	270..547	CDD:133454	104/276 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159170
Domainoid	1	1.000	46	1.000	Domainoid score	I12124
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60768
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	1	1.100	-	-	O	PTHR23406
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.710