DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Menl-2 and Me3

DIOPT Version :9

Sequence 1:	NP_001027424.2	Gene:	Menl-2 / 3772692	FlyBaseID:	FBgn0029153	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_001101961.2	Gene:	Me3 / 361602	RGDID:	1311070	Length:	605	Species:	Rattus norvegicus

Alignment Length:	552	Identity:	228/552 - (41%)
Similarity:	341/552 - (61%)	Gaps:	10/552 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 WHVVMNGKYNKGLAFTIKERQRLGIMGLMPCSVRSMDDQMNAALANFEARPTDIARFTYLSAVHH 103
            :.|..|...|||:|||::||.:|||.||:|....|.|.|:...:..:|.:.:|:.::..|..:..
  Rat    51 YDVTRNPHLNKGMAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYENQQSDLDKYIILMTLQD 115

  Fly   104 RHRRLYYRFIKENIEKSLPIVYTPTVGDVVATYGLNFQQAISLFISIHDKGHIRDLMHNWVDEGV 168
            |:.:|:||.:..::||.:|||||||||.....|||.|::...|||:|||||||..::::|.::.:
  Rat   116 RNEKLFYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDKGHIATMLNSWPEDNI 180

  Fly   169 KAICVTDGGRVLGLGDMGANAMGISLGKMILYTALGSIPPSTLMPVCLDVGTDNQALLQDPLYVG 233
            ||:.||||.|:|||||:|...|||.:||:.||||.|.:.|...:||.|||||:|:.||:||||:|
  Rat   181 KAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPQQCLPVLLDVGTNNEELLRDPLYIG 245

  Fly   234 ARIPRVKGPEYDELVDEFMESAVKCFGNNTFIHFEDFATPNALKFLEKYQYKYCCFNDDIQGTGA 298
            .:..||:|.|||:|:||||::....||.|..|.|||||..||.:.|.||:.|||.||||||||.:
  Rat   246 LKHQRVRGKEYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCMFNDDIQGTAS 310

  Fly   299 TGLAAFINVERITGRKLEDTVFLFVGAGSAALGIANMLAMELEVRGIPAEEATKNIYLMDVNGIL 363
            ..:|..:...|||..:|.:.||:|.|||.||:|||::|.|.||..|||..||.:.|:::|..|::
  Rat   311 VAVAGILAALRITKNRLSNHVFVFQGAGEAAMGIAHLLVMALEKEGIPKTEAVRKIWMVDSKGLI 375

  Fly   364 TPESPNPPEMGKIFIKSMEPMKDMMAVLKKLKPSVLVGATGVGGIFNEEVLKTMAKNHERPAVFP 428
            .....:.....::|.:....:..:..|::.:||:.::|...:.|.|.|::|:.||..||||.:|.
  Rat   376 VKGRSHLNHEKEMFAQEHPEVNSLEEVVRLVKPTAIIGVAAIAGAFTEQILRDMASFHERPIIFA 440

  Fly   429 LSNPTANSECTAEQAFTHTEGRVLFGSGSPFPPVVI-NGKRYRPAQANNCLTFPGIALAAITAKA 492
            |||||:.:|||||:.:..||||.:|.|||||..|.: :|:.:.|.|.||...|||:||..|....
  Rat   441 LSNPTSKAECTAEKCYQVTEGRGIFASGSPFKSVTLEDGRTFIPGQGNNAYVFPGVALGIIAGGI 505

  Fly   493 RYLPNEVFSVVSHELARNTPQELLDEGTLFPPIKDAHNVAFNVGVA-----MTQYLIDNDLSNVY 552
            |::|:|:|.:.:...|.|....   |.|....::...: |....||     :..|...::|::.|
  Rat   506 RHVPDEIFLLTAEVAAWNIKHV---EETRIQEVRGTES-AVQPAVASQRTKVLDYAYKHNLASYY 566

  Fly   553 PKPDDICEFVKRSLYKFDYRNSLPTTWDYPVE 584
            |:|.|...|:|..:|..||.:....|:.:|.|
  Rat   567 PEPKDKEAFIKSLIYTPDYDSFSLDTYTWPKE 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Menl-2	NP_001027424.2	PLN03129	8..573	CDD:215594	225/539 (42%)
		malic	102..283	CDD:278802	93/180 (52%)
		NADB_Rossmann	293..567	CDD:304358	99/279 (35%)
Me3	NP_001101961.2	PLN03129	9..588	CDD:215594	225/540 (42%)
		malic	114..295	CDD:278802	93/180 (52%)
		NAD_bind_1_malic_enz	305..583	CDD:133454	100/281 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353183
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60768
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	1	1.100	-	-	O	PTHR23406
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.710