Protein Alignment Menl-2 and men-1

DIOPT Version :10

• Sequence 1: NP_001027424.2
• Gene: Menl-2 / 3772692
• FlyBaseID: FBgn0029153
• Length: 600
• Species: Drosophila melanogaster
• Sequence 2: NP_496968.1
• Gene: men-1 / 175079
• WormBaseID: WBGene00012983
• Length: 620
• Species: Caenorhabditis elegans
• Alignment Length: 600
• Identity: 233/600 - (38%)
• Similarity: 361/600 - (60%)
• Gaps: 15/600 - (2%)

  Fly     4 RRLHPLLRLAS---RPLLSSSRRFSVYDDEMEQITRPDWH---VVMNGKYNKGLAFTIKERQRLG 62
            |||....|..|   .|.||..:..:::.....:.|.|...   ::.:...|||:||::.|||.||
 Worm    11 RRLSTSTRCLSDKNEPDLSDPKTLALHKLYRPERTTPQKRGIDLLKSPGLNKGMAFSLHERQYLG 75

  Fly    63 IMGLMPCSVRSMDDQMNAALANFEARPTDIARFTYLSAVHHRHRRLYYRFIKENIEKSLPIVYTP 127
            :.||:|.:..:.:.|....:.....:|.::|::..|.::..|:.:||||.:.:|:::.:||||||
 Worm    76 VHGLLPPAFMTEEQQAYRIITKLRQQPDNLAKYIQLDSLQDRNEKLYYRVLCDNVKELMPIVYTP 140

  Fly   128 TVGDVVATYGLNFQQAISLFISIHDK--GHIRDLMHNWVDEGVKAICVTDGGRVLGLGDMGANAM 190
            |||.....:|..::....|:|:|:|.  ..|..::.||..|.|:||.:|||.|:|||||:|...:
 Worm   141 TVGQACQHFGFIYRNPKGLYITINDNSISKIHQILANWPTENVRAIVITDGERILGLGDLGTYGI 205

  Fly   191 GISLGKMILYTALGSIPPSTLMPVCLDVGTDNQALLQDPLYVGARIPRVKGPEYDELVDEFMESA 255
            ||.:||:.||.||..|.|...:||.|||||||..||.||.|.|.|..||:|||||.|||.||::|
 Worm   206 GIPVGKLALYVALAGIRPEWCLPVILDVGTDNSELLNDPFYTGLRRKRVRGPEYDTLVDNFMKAA 270

  Fly   256 VKCFGNNTFIHFEDFATPNALKFLEKYQYKYCCFNDDIQGTGATGLAAFINVERITGRKLEDTVF 320
            .|.||.:|.|.||||...||.:.|::|:.:||.||||||||.|..:|..:...|||.:||.....
 Worm   271 TKRFGRDTLIQFEDFGNQNAYRLLDRYKGEYCMFNDDIQGTAAVVVAGLLASTRITKKKLSQERI 335

  Fly   321 LFVGAGSAALGIANMLAMELEVRGIPAEEATKNIYLMDVNGIL-TPESPNPPEMGKIFIKSMEPM 384
            :|:|||.||.|:|.|...::...|:..|||...||::|:.|:: |..|.:..|....|.|.:...
 Worm   336 VFLGAGGAATGVAEMCVRQMMDEGLSEEEACGRIYMVDIEGLITTSRSKSLGERHVKFAKDLPDT 400

  Fly   385 KDMMAVLKKLKPSVLVGATGVGGIFNEEVLKTMAKNHERPAVFPLSNPTANSECTAEQAFTHTEG 449
            |:::.|:|.:||..|:||:.|.|.|.|:::|.||:.:.||.:|.|||||:.:|||||.|:..|.|
 Worm   401 KNLLEVVKTVKPGALIGASTVAGAFTEDIIKEMARLNPRPIIFALSNPTSKAECTAETAYRCTNG 465

  Fly   450 RVLFGSGSPFPPVVINGKRYRPAQANNCLTFPGIALAAITAKARYLPNEVFSVVSHELARNTPQE 514
            .|||.|||||..|.:|||.|:|.|.||...|||:||.|:..:.:.:|:::|.:.:..:|....::
 Worm   466 AVLFASGSPFENVEMNGKLYKPGQGNNAYIFPGVALGAVLFRTKNIPDKLFLLAARMVAEAVSEK 530

  Fly   515 LLDE-GTLFPPIKDAHNVAFNVGVAMTQYLIDNDLSNVYPKPDDICEFVKRSLYKFDYRNSLPTT 578
            .|:. ..::|.:||...::..:.|.:.:|...:||:.::|||||:..|::::||..:|...:..|
 Worm   531 SLNTYSRVYPRLKDIRELSVKIAVEVGEYCYRHDLATLHPKPDDMEMFIRQNLYSVEYDELINKT 595

  Fly   579 WDYPVEP-----PTP 588
            :::|.:.     |.|
 Worm   596 YEWPAKDSKHGFPVP 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Menl-2	NP_001027424.2	PLN03129	8..573	CDD:215594	226/574 (39%)
men-1	NP_496968.1	PLN03129	46..592	CDD:215594	220/545 (40%)