DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Menl-2 and Me1

DIOPT Version :9

Sequence 1:	NP_001027424.2	Gene:	Menl-2 / 3772692	FlyBaseID:	FBgn0029153	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_032641.2	Gene:	Me1 / 17436	MGIID:	97043	Length:	572	Species:	Mus musculus

Alignment Length:	561	Identity:	244/561 - (43%)
Similarity:	350/561 - (62%)	Gaps:	10/561 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 ITRPDWHVVMNGKYNKGLAFTIKERQRLGIMGLMPCSVRSMDDQMNAALANFEARPTDIARFTYL 98
            :|| |.|:      ||.||||::|||:|.|.||:|..:.|.:.|:...:.|||...:|..|:..|
Mouse    18 LTR-DPHL------NKDLAFTLEERQQLNIHGLLPPCIISQELQVLRIIKNFERLNSDFDRYLLL 75

  Fly    99 SAVHHRHRRLYYRFIKENIEKSLPIVYTPTVGDVVATYGLNFQQAISLFISIHDKGHIRDLMHNW 163
            ..:..|:.:|:|..:..::||.:|||||||||.....|.|.|::...|||||||||||..:::.|
Mouse    76 MDLQDRNEKLFYSVLMSDVEKFMPIVYTPTVGLACQQYSLAFRKPRGLFISIHDKGHIASVLNAW 140

  Fly   164 VDEGVKAICVTDGGRVLGLGDMGANAMGISLGKMILYTALGSIPPSTLMPVCLDVGTDNQALLQD 228
            .::.||||.||||.|:|||||:|.|.|||.:||:.||||.|.:.|...:|:.|||||:|:.||:|
Mouse   141 PEDVVKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGVNPQQCLPITLDVGTENEELLKD 205

  Fly   229 PLYVGARIPRVKGPEYDELVDEFMESAVKCFGNNTFIHFEDFATPNALKFLEKYQYKYCCFNDDI 293
            |||:|.|..||:|||||..:|||||:|...:|.|..|.|||||..||.:.|.||:.|||.|||||
Mouse   206 PLYIGLRHRRVRGPEYDAFLDEFMEAASSKYGMNCLIQFEDFANRNAFRLLNKYRNKYCTFNDDI 270

  Fly   294 QGTGATGLAAFINVERITGRKLEDTVFLFVGAGSAALGIANMLAMELEVRGIPAEEATKNIYLMD 358
            |||.:..:|..:...|||..||.|...||.|||.||||||:::.|.:|..|:..|.|.|.|:|:|
Mouse   271 QGTASVAVAGLLAALRITKNKLSDQTVLFQGAGEAALGIAHLVVMAMEKEGLSKENARKKIWLVD 335

  Fly   359 VNGILTPESPNPPEMGKIFIKSMEPMKDMMAVLKKLKPSVLVGATGVGGIFNEEVLKTMAKNHER 423
            ..|::.....:..|..::|....|.||::.|:::|:||:.|:|...:||.|.|::||.||..:||
Mouse   336 SKGLIVKGRASLTEEKEVFAHEHEEMKNLEAIVQKIKPTALIGVAAIGGAFTEQILKDMAAFNER 400

  Fly   424 PAVFPLSNPTANSECTAEQAFTHTEGRVLFGSGSPFPPVVI-NGKRYRPAQANNCLTFPGIALAA 487
            |.:|.|||||:.:||:|||.:..|:||.:|.|||||.||.: :|:...|.|.||...|||:||..
Mouse   401 PIIFALSNPTSKAECSAEQCYKVTKGRAIFASGSPFDPVTLPDGRTLFPGQGNNSYVFPGVALGV 465

  Fly   488 ITAKARYLPNEVFSVVSHELARNTPQELLDEGTLFPPIKDAHNVAFNVGVAMTQYLIDNDLSNVY 552
            :....|::.::||...:..:::....:.|.||.|:||:.....|:..:.|.:.|......::.||
Mouse   466 VACGLRHIDDKVFLTTAEVISQQVSDKHLQEGRLYPPLNTIRGVSLKIAVKIVQDAYKEKMATVY 530

  Fly   553 PKPDDICEFVKRSLYKFDYRNSLPTTWDYPVEPPTPKPKTK 593
            |:|.:..|||...:|..:|...||..:.:|.|  ..|.:||
Mouse   531 PEPQNKEEFVSSQMYSTNYDQILPDCYPWPAE--VQKIQTK 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Menl-2	NP_001027424.2	PLN03129	8..573	CDD:215594	237/539 (44%)
		malic	102..283	CDD:278802	96/180 (53%)
		NADB_Rossmann	293..567	CDD:304358	105/274 (38%)
Me1	NP_032641.2	PLN03129	2..551	CDD:215594	237/539 (44%)
		malic	79..260	CDD:278802	96/180 (53%)
		NAD_bind_1_malic_enz	270..547	CDD:133454	106/276 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849540
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60768
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	1	1.100	-	-	O	PTHR23406
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.710