Protein Alignment Menl-2 and Me2

DIOPT Version :9

• Sequence 1: NP_001027424.2
• Gene: Menl-2 / 3772692
• FlyBaseID: FBgn0029153
• Length: 600
• Species: Drosophila melanogaster
• Sequence 2: XP_006525559.1
• Gene: Me2 / 107029
• MGIID: 2147351
• Length: 596
• Species: Mus musculus
• Alignment Length: 599
• Identity: 239/599 - (39%)
• Similarity: 356/599 - (59%)
• Gaps: 30/599 - (5%)

  Fly    10 LRLASRPLLSSSRRFSVYDDEMEQITRPDWHVVMNGKYNKGLAFTIKERQRLGIMGLMPCSVRSM 74
            ||..:.|...:.||.     .:::..:|   :::|.:.|||:|||::|||.||:.||:|..:.:.
Mouse    12 LRAVTTPCTLTCRRV-----HLKEKGKP---LMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQ 68

  Fly    75 DDQMNAALANFEARPTDIARFTYLSAVHHRHRRLYYRFIKENIEKSLPIVYTPTVGDVVATYGLN 139
            |.|......|.:...:.:.::.|:..:..|:.:|:||.::::||..:|||||||||.....||..
Mouse    69 DIQALRFHRNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACCQYGHI 133

  Fly   140 FQQAISLFISIHDKGHIRDLMHNWVDEGVKAICVTDGGRVLGLGDMGANAMGISLGKMILYTALG 204
            |::...|||||.|:||:|.::.||.:..|||:.||||.|:|||||:|...|||.:||:.||||..
Mouse   134 FRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACA 198

  Fly   205 SIPPSTLMPVCLDVGTDNQALLQDPLYVGARIPRVKGPEYDELVDEFMESAVKCFGNNTFIHFED 269
            .|.|...:|||:||||||.|||:||.|:|....|.:...||:|:||||::....:|.||.|.|||
Mouse   199 GIQPEKCLPVCIDVGTDNMALLKDPFYMGLYQKRDRSQLYDDLMDEFMKAITDRYGRNTLIQFED 263

  Fly   270 FATPNALKFLEKYQYKYCCFNDDIQGTGATGLAAFINVERITGRKLEDTVFLFVGAGSAALGIAN 334
            |...||.:||.|||.|||.||||||||.|..|:..:..:|:..:.:.:...||:|||.|||||||
Mouse   264 FGNHNAFRFLRKYQQKYCTFNDDIQGTAAVALSGLLAAQRVINKPVSEHKILFLGAGEAALGIAN 328

  Fly   335 MLAMELEVRGIPAEEATKNIYLMDVNGILT------------PESPNPPEMGKIFIKSMEPMKDM 387
            ::.:.:...|:..|||.:.|::.|.:|:|.            |.:...||......:.
Mouse   329 LIVLSMVESGLSEEEAQRKIWMFDKSGLLVKGRTASIDSNQEPYAHAAPESIPATFED------- 386

  Fly   388 MAVLKKLKPSVLVGATGVGGIFNEEVLKTMAKNHERPAVFPLSNPTANSECTAEQAFTHTEGRVL 452
              .:.||||||::|..|.|.:|...|:|.||..:|||.:|.||||||.:|||||.|:|.||||.|
Mouse   387 --AVNKLKPSVIIGVAGAGPLFTHGVIKAMASINERPIIFALSNPTAQAECTAEDAYTLTEGRCL 449

  Fly   453 FGSGSPFPPVVI-NGKRYRPAQANNCLTFPGIALAAITAKARYLPNEVFSVVSHELARNTPQELL 516
            |.|||||.||.: :|:.:.|.|.||...|||:|||.|..:||::.:.||...:..|........|
Mouse   450 FASGSPFEPVKLQDGRVFTPGQGNNAYIFPGVALAVILCEARHISDTVFLEAAKALTTQLTDAEL 514

  Fly   517 DEGTLFPPIKDAHNVAFNVGVAMTQYLIDNDLSNVYPKPDDICEFVKRSLYKFDYRNSLPTTWDY 581
            .:|.|:|.:.:...|:.|:.:.:.:||..|.::..||:|:|...:|:..:::.:|.:.||..:|:
Mouse   515 AQGRLYPSLANIQEVSANIAIKLAEYLYANKMAFRYPEPEDKARYVRERIWRSNYVSLLPDVYDW 579

  Fly   582 PVEPPTPKPKTKPK 595
            |....||...|:.|
Mouse   580 PESSLTPPQITEEK 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Menl-2	NP_001027424.2	PLN03129	8..573	CDD:215594	231/575 (40%)
		malic	102..283	CDD:278802	91/180 (51%)
		NADB_Rossmann	293..567	CDD:304358	105/286 (37%)
Me2	XP_006525559.1	PLN03129	35..573	CDD:215594	225/546 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849530
Domainoid	1	1.000	46	1.000	Domainoid score	I12052
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60768
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.610