DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ste24c and ste24a

DIOPT Version :9

Sequence 1:	NP_001027433.1	Gene:	ste24c / 3772676	FlyBaseID:	FBgn0050462	Length:	456	Species:	Drosophila melanogaster
Sequence 2:	NP_611175.1	Gene:	ste24a / 36908	FlyBaseID:	FBgn0034176	Length:	451	Species:	Drosophila melanogaster

Alignment Length:	454	Identity:	167/454 - (36%)
Similarity:	266/454 - (58%)	Gaps:	17/454 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VDPIIVLVVLCLIVLVDRIWEMILTKRQQLVCLNAIMVPEELRGIIPPEIYHRARIYELHKTELQ 74
            :|...||:.:..:|:::...|:.::.||..|...|:.||.||:..:..:.:|:||.|.|.:.:..
  Fly     4 LDADTVLLSILFLVVIENALEIYISLRQVKVYQTALKVPAELKSHMGEDTFHKARKYGLDQEKFG 68

  Fly    75 IWKYLIDLIITLC-ELILGFYPFLWSLSAKTLQKI---TSQEIWITLIFVFYLTIYICIRFLPVL 135
            |:|.::..:..|| ||.:|....||.||.:.:.|:   :..||.::.:||....:....:.||..
  Fly    69 IFKAVVMDVALLCMELYIGLIAVLWQLSVQVVDKLQWDSKNEIIVSCVFVLISNVLSTFKGLPFK 133

  Fly   136 IYDKCLLELRYGMSGK----FPWYLYCCIGAMSILLSQLVLFPLAAAIVFSVKFIGYYFFLWFWL 196
            ||...:||..:|.:.:    |.|     ......|::|:::.|:.|||:|.|:..|..||:|.|:
  Fly   134 IYKIFVLEETHGFNKQTARFFAW-----DQLKGFLVTQVLMIPITAAIIFIVQRGGDNFFIWLWI 193

  Fly   197 FWATFTLLLVFFLPYCCIPCIGRQVVLPEGTALYMEVKRVCDVVGFPMKRVFIIK-TRTMQYSNA 260
            |....:|:|:...|....|...:...|.:| ||...::.:...:.||:.::|::: ::...:|||
  Fly   194 FTGVISLVLLTLYPIFIAPLFDKYTPLEKG-ALRQSIEDLAASLKFPLTKLFVVEGSKRSSHSNA 257

  Fly   261 YFYGSCCLKRIVIFDTLLLNKGK-EPNEIHPYEVGRGLTNIQVAGVVCHELGHWKHGHFYKATII 324
            ||||....||||:|||||||||| :.:|:...|.|:|.|:.:|..|:.|||||||.||..|..||
  Fly   258 YFYGLWNSKRIVLFDTLLLNKGKPDDSELSEEEKGKGCTDEEVLAVLGHELGHWKLGHVTKNIII 322

  Fly   325 MKIHFFITMGLFGLFFHSPQLYMAVGFEPGVMPIIVGFIIVLKFALTPYLTLANVLMLWNLRRFE 389
            |::|.|:...:||..|..|..|:|:||:||..||:||.:||..:.|.||..|.|..|....||||
  Fly   323 MQVHLFLMFLVFGNVFKYPPFYVAMGFQPGTRPILVGLLIVFTYVLAPYNALMNFAMTILSRRFE 387

  Fly   390 YAADKFAHRMGYSIQLRMALVKIYADHMSFPVYDQCYARWHHTHPTILQRLAYQQKL-DVKAMN 452
            |.||:||.::|::.||..||:|:..|::.|||||..|:.|:|:|||:||||...::| :.|.:|
  Fly   388 YQADEFAFKLGFAEQLGQALIKLNVDNLGFPVYDWLYSTWNHSHPTLLQRLNRLKELKEEKKLN 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ste24c	NP_001027433.1	Peptidase_M48_N	37..215	CDD:293100	54/185 (29%)
		HtpX	131..452	CDD:223575	132/327 (40%)
		Peptidase_M48	229..441	CDD:299867	99/213 (46%)
ste24a	NP_611175.1	Peptidase_M48_N	31..216	CDD:293100	55/189 (29%)
		HtpX	153..440	CDD:223575	123/292 (42%)
		Peptidase_M48	219..439	CDD:279743	102/220 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450189
Domainoid	1	1.000	187	1.000	Domainoid score	I974
eggNOG	1	0.900	-	-		E1_COG0501
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002450
OrthoInspector	1	1.000	-	-		otm46568
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10120
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.840