DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ste24c and ste24b

DIOPT Version :9

Sequence 1:	NP_001027433.1	Gene:	ste24c / 3772676	FlyBaseID:	FBgn0050462	Length:	456	Species:	Drosophila melanogaster
Sequence 2:	NP_611174.1	Gene:	ste24b / 36907	FlyBaseID:	FBgn0034175	Length:	447	Species:	Drosophila melanogaster

Alignment Length:	444	Identity:	173/444 - (38%)
Similarity:	272/444 - (61%)	Gaps:	13/444 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FYDTWPKVDPIIVLVVLCLIVLVDRIWEMILTKRQQLVCLNAIMVPEELRGIIPPEIYHRARIYE 67
            |:|     ||:.:|.::...:::|.:|.:.|..|...|......||..:...:|.|:|.:.|:|:
  Fly     5 FWD-----DPLAILYIIIAFLVLDNLWGVYLMLRDIQVAYKTQQVPNVISPYLPQELYDKMRVYK 64

  Fly    68 LHKTELQIWKYLID-LIITLCELILGFYPFLWSLSAK-TLQKITSQEIWITLIFVFYLTIYICIR 130
            :||....|...|:. :|:.:.||..|||.:|:.::.| .|.|....|..:::|||..|::|..::
  Fly    65 IHKGWFTIVNTLLSAVILGIMELYFGFYAWLYGVAGKCALSKWMEHEACVSVIFVLLLSVYFWLK 129

  Fly   131 FLPVLIYDKCLLELRYGMSGKFPWYLYCCIGAMSILLSQLVLFPLAAAIVFSVKFIGYYFFLWFW 195
            .:|.:||:.|.:: ......|.||:...|...:.:::..::...:..|:|:....:|.|..|..:
  Fly   130 SVPAMIYESCCIK-SLQPRPKPPWWSRICHFVVDLVVGAMITTLVVVALVYMFIGLGPYAPLGLY 193

  Fly   196 LFWATFTLLLVFFLPYCCIPCIGRQVVLPEGTALYMEVKRVCDVVGFPMKRVFIIKTRTMQY-SN 259
            |.....|::::..:|:...|.:|:.|.| |.:.|..:::.:...|||||.:|.||:...... ||
  Fly   194 LQSLILTMIVLLLIPFMIHPFVGQSVPL-ENSNLRTQLEYLTRQVGFPMSQVRIIRVHDPNTGSN 257

  Fly   260 AYFYGSCCLKRIVIFDTLLLNKGK-EPNEIHPYEVGRGLTNIQVAGVVCHELGHWKHGHFYKATI 323
            |:|||.|||||||||||||||:|| :.:.:...|:||||.:.||..||.||||||::||||||.:
  Fly   258 AFFYGCCCLKRIVIFDTLLLNRGKSDLSHLTAEELGRGLADPQVVAVVAHELGHWRNGHFYKAIM 322

  Fly   324 IMKIHFFITMGLFG-LFFHSPQLYMAVGFEPGVMPIIVGFIIVLKFALTPYLTLANVLMLWNLRR 387
            ..::|..:|:.||. ||.|.| :|.||||.||:.|.::|.:|:..|.||||:||||..||...|.
  Fly   323 AFQVHLILTILLFAFLFSHGP-IYQAVGFPPGLQPTVIGCLIIFGFVLTPYMTLANFSMLSMTRC 386

  Fly   388 FEYAADKFAHRMGYSIQLRMALVKIYADHMSFPVYDQCYARWHHTHPTILQRLA 441
            |||.||:||:::||..:||.||:|:|||:::|||.|.||:.|:|||||:|.||:
  Fly   387 FEYQADRFAYQLGYGGELRQALLKLYADNLAFPVSDPCYSSWNHTHPTMLDRLS 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ste24c	NP_001027433.1	Peptidase_M48_N	37..215	CDD:293100	44/179 (25%)
		HtpX	131..452	CDD:223575	136/314 (43%)
		Peptidase_M48	229..441	CDD:299867	114/214 (53%)
ste24b	NP_611174.1	Peptidase_M48_N	35..214	CDD:293100	44/179 (25%)
		HtpX	167..444	CDD:223575	128/276 (46%)
		Peptidase_M48	220..444	CDD:279743	117/223 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450185
Domainoid	1	1.000	187	1.000	Domainoid score	I974
eggNOG	1	0.900	-	-		E1_COG0501
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61664
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002450
OrthoInspector	1	1.000	-	-		otm46568
orthoMCL	1	0.900	-	-		OOG6_104985
Panther	1	1.100	-	-	P	PTHR10120
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.750