DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ste24c and Zmpste24

DIOPT Version :9

Sequence 1:	NP_001027433.1	Gene:	ste24c / 3772676	FlyBaseID:	FBgn0050462	Length:	456	Species:	Drosophila melanogaster
Sequence 2:	NP_001101444.1	Gene:	Zmpste24 / 313564	RGDID:	1305570	Length:	475	Species:	Rattus norvegicus

Alignment Length:	440	Identity:	132/440 - (30%)
Similarity:	231/440 - (52%)	Gaps:	32/440 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 IWEMILTKRQQLVCLNAIMVPEELRGIIPPEIYHRARIYELHKTELQIWKYLIDLIITLCELILG 92
            :||..|.:||:.:......||.||..|:..:.:.::|:|:|.|:....|..|...:.....|:.|
  Rat    32 LWETFLAQRQRRIYKTTTHVPPELEQIMDSDTFEKSRLYQLDKSTFSFWSGLYSEVEGTFILLFG 96

  Fly    93 FYPFLWSLSAKTLQKI---TSQEIWITLIFVFYLTIYICIRFLPVLIYDKCLLELRYGMSGK-FP 153
            ..|:||.||.:.....   ...||..:|:|:...|::..:..||..:|:..::|.::|.:.: ..
  Rat    97 GIPYLWRLSGRFCSSAGFGPEYEIIQSLVFLLLATLFSALTGLPWSLYNTFVIEEKHGFNHQTLE 161

  Fly   154 WYLYCCIGAMSILLSQLVLFPLAAAIVFSVKFIGYYFFLWFWLFWATFTLLLVFFLPYCCIPCIG 218
            :::...|  ...:::|.:|.|:::.:::.:|..|.|||::.|||....:|:||........|...
  Rat   162 FFMKDAI--KKFIVTQCILLPVSSLLLYIIKIGGDYFFIYAWLFTLVVSLVLVTIYADYIAPLFD 224

  Fly   219 RQVVLPEGTALYMEVKRVCDVVGFPMKRVFIIK-TRTMQYSNAYFYGSCCLKRIVIFDTLLLNKG 282
            :...|||| .|..|::.:...:.||:.:|:::: ::...:|||||||....||||:||| ||.:.
  Rat   225 KFTPLPEG-KLKQEIEVMAKSIDFPLTKVYVVEGSKRSSHSNAYFYGFFKNKRIVLFDT-LLEEY 287

  Fly   283 KEPNEIHPYEVG----------------------RGLTNIQVAGVVCHELGHWKHGHFYKATIIM 325
            ..||:.:..|.|                      :|..|.:|..|:.|||||||.||..|..||.
  Rat   288 SVPNKDNQEEPGLEPRNEGEGDSEEVKSKVKNKKQGCKNEEVLAVLGHELGHWKLGHTVKNIIIS 352

  Fly   326 KIHFFITMGLFGLFFHSPQLYMAVGFEPGVMPIIVGFIIVLKFALTPYLTLANVLMLWNLRRFEY 390
            :::.|:...||.:.....:|:.|.||... .|.::|.:|:.:|..:||..:.:..:....||||:
  Rat   353 QMNSFLCFFLFAVLIGRRELFAAFGFYDS-QPTLIGLLIIFQFIFSPYNEVLSFCLTVLSRRFEF 416

  Fly   391 AADKFAHRMGYSIQLRMALVKIYADHMSFPVYDQCYARWHHTHPTILQRL 440
            .||.||.::|.:..|..||:|:..|::.|||.|..::.||::||.:|:||
  Rat   417 QADAFAKKLGKAKDLYSALIKLNKDNLGFPVSDWLFSTWHYSHPPLLERL 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ste24c	NP_001027433.1	Peptidase_M48_N	37..215	CDD:293100	44/181 (24%)
		HtpX	131..452	CDD:223575	104/334 (31%)
		Peptidase_M48	229..441	CDD:299867	79/235 (34%)
Zmpste24	NP_001101444.1	Peptidase_M48_N	41..225	CDD:293100	45/185 (24%)
		HtpX	124..474	CDD:223575	107/348 (31%)
		Peptidase_M48	228..471	CDD:279743	83/242 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341845
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0501
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61664
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002450
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10120
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.810