Protein Alignment ste24c and ZMPSTE24

DIOPT Version :10

• Sequence 1: NP_001027433.1
• Gene: ste24c / 3772676
• FlyBaseID: FBgn0050462
• Length: 456
• Species: Drosophila melanogaster
• Sequence 2: NP_005848.2
• Gene: ZMPSTE24 / 10269
• HGNCID: 12877
• Length: 475
• Species: Homo sapiens
• Alignment Length: 443
• Identity: 139/443 - (31%)
• Similarity: 233/443 - (52%)
• Gaps: 38/443 - (8%)

  Fly    28 IWEMILTKRQQLVCLNAIMVPEELRGIIPPEIYHRARIYELHKTELQIWKYLIDLIITLCELILG 92
            :||..|.:||:.:......||.||..|:..|.:.::|:|:|.|:....|..|.........|:.|
Human    32 LWETFLAQRQRRIYKTTTHVPPELGQIMDSETFEKSRLYQLDKSTFSFWSGLYSETEGTLILLFG 96

  Fly    93 FYPFLWSLSAKTLQKI---TSQEIWITLIFVFYLTIYICIRFLPVLIYDKCLLELRYGMSGK-FP 153
            ..|:||.||.:.....   ...||..:|:|:...|::..:..||..:|:..::|.::|.:.: ..
Human    97 GIPYLWRLSGRFCGYAGFGPEYEITQSLVFLLLATLFSALTGLPWSLYNTFVIEEKHGFNQQTLG 161

  Fly   154 WYLYCCIGAMSILLSQLVLFPLAAAIVFSVKFIGYYFFLWFWLFWATFTLLLVFFLPYCCIPCIG 218
            :::...|  ...:::|.:|.|:::.:::.:|..|.|||::.|||....:|:||........|...
Human   162 FFMKDAI--KKFVVTQCILLPVSSLLLYIIKIGGDYFFIYAWLFTLVVSLVLVTIYADYIAPLFD 224

  Fly   219 RQVVLPEGTALYMEVKRVCDVVGFPMKRVFIIK-TRTMQYSNAYFYGSCCLKRIVIFDTLL---- 278
            :...|||| .|..|::.:...:.||:.:|:::: ::...:|||||||....||||:|||||
Human   225 KFTPLPEG-KLKEEIEVMAKSIDFPLTKVYVVEGSKRSSHSNAYFYGFFKNKRIVLFDTLLEEYS 288

  Fly   279 -LNK------GKEP-NEIHPYEVG-------------RGLTNIQVAGVVCHELGHWKHGHFYKAT 322
             |||      |.|| ||    |.|             :|..|.:|..|:.|||||||.||..|..
Human   289 VLNKDIQEDSGMEPRNE----EEGNSEEIKAKVKNKKQGCKNEEVLAVLGHELGHWKLGHTVKNI 349

  Fly   323 IIMKIHFFITMGLFGLFFHSPQLYMAVGFEPGVMPIIVGFIIVLKFALTPYLTLANVLMLWNLRR 387
            ||.:::.|:...||.:.....:|:.|.||... .|.::|.:|:.:|..:||..:.:..:....||
Human   350 IISQMNSFLCFFLFAVLIGRKELFAAFGFYDS-QPTLIGLLIIFQFIFSPYNEVLSFCLTVLSRR 413

  Fly   388 FEYAADKFAHRMGYSIQLRMALVKIYADHMSFPVYDQCYARWHHTHPTILQRL 440
            ||:.||.||.::|.:..|..||:|:..|::.|||.|..::.||::||.:|:||
Human   414 FEFQADAFAKKLGKAKDLYSALIKLNKDNLGFPVSDWLFSMWHYSHPPLLERL 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ste24c	NP_001027433.1	M48A_Zmpste24p_like	28..445	CDD:320702	139/443 (31%)
ZMPSTE24	NP_005848.2	M48A_Zmpste24p_like	22..470	CDD:320702	139/443 (31%)