DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bbx and cica

DIOPT Version :9

Sequence 1:	NP_001027087.1	Gene:	bbx / 3772670	FlyBaseID:	FBgn0024251	Length:	769	Species:	Drosophila melanogaster
Sequence 2:	XP_003200581.2	Gene:	cica / 560266	ZFINID:	ZDB-GENE-060503-700	Length:	2440	Species:	Danio rerio

Alignment Length:	901	Identity:	197/901 - (21%)
Similarity:	292/901 - (32%)	Gaps:	297/901 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 INGLSVGG----------------GQQVAQVTPTGAAIKLHFAYNNNSNNSSSSNISNSNYS--- 47
            |||.:..|                .|.:|.|.|         .|..:| ||::.|:|.||.:
Zfish  1055 INGATTNGAVLLRNPAPTLVLVTSSQSLAPVAP---------GYPTHS-NSTALNVSTSNATTGP 1109

  Fly    48 --GLKTSETKMRNNKNYTGRAL-KIVEKIPGASGVIATTSGNQGARSLEGYSPAAASYVSGLSRD 109
              .:..|..|.:..|:..|.|| :.|...|..:.::...        |...||..|.     .:|
Zfish  1110 ALAISGSGGKDQERKSDAGSALPQPVACHPSPTALLPLI--------LPAESPHPAP-----RKD 1161

  Fly   110 FLISRELSQRSGEFLTAAAKMVSQMGASELRW---LPISRTKDKPSSAGEAEAKTLVREG-ESQG 170
            .::.     |.|...|    .|.........|   :|...|.....|...|:.:|||.:. |.:.
Zfish  1162 IIMG-----RPGTVWT----NVEPRSVPVFAWHSLVPFLETSQTKMSTQPADGQTLVNQSKEPRC 1217

  Fly   171 SPGKVAKSALGDPQPQRTEDQENAFRRIEDVHNYAKLQDCSSDTDDEDDEEEDLDEEEDDEEEAE 235
            ....|::.....|.|:|                       .|.:......|:...|.|..:.|.|
Zfish  1218 GVALVSEGLTDHPTPER-----------------------GSPSCPPPSAEDPPVEREGGDSETE 1259

  Fly   236 IQVQLPVQQEVTRIRREAAEEHVDVDVVTVPQQEQDQYSHQVEP--RQLQQ----DETADNTRPE 294
                                  .|.|.:.:|....|. |..:.|  |:.|.    .:..|..|.:
Zfish  1260 ----------------------SDADDLFLPGVVPDS-SPSLNPVKRRTQSLSALPKDGDKKREK 1301

  Fly   295 HHARRPMNAFLIFCKRHRGIVKERYKTLENRAITKILGDWWAALDEQEKHCFTDLAQQNKDAFFN 359
            .|.|||||||:||.||||.:|.:|:...:||.::||||:||.||..:||..:.|||.|.|:|.|.
Zfish  1302 DHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFR 1366

  Fly   360 ANPNFKWYKLP-------------APPLR----TLATRPSNASAGL----LIPSEDQP------- 396
            |:|::||....             |...|    :.:|.|.:.|.|.    ..||...|
Zfish  1367 AHPDWKWCNKDRRKSLSEGRGTPGAKDARERSVSESTEPHSTSQGAEHKGAGPSWTSPPSDCHGR 1431

  Fly   397 ----QQQVPTSLQ---VQWAERGEMPRAM--------------LRPNYFKLADETQMGELSSLLQ 440
                |.|.|.:..   |...||.|..|.:              .||:....:||..|
Zfish  1432 SPAGQLQRPRAFSQSAVHTLERREKERELDSGSLFQARPLTRPRRPSEDVTSDEEHM-------- 1488

  Fly   441 VQVQE-KDFALQQVLSETSQFLSAHMPAGNTNGNGNKRSLQDNNSSNSSEEEAASGSSPNKKVKS 504
            |..:| .|..::...:|.|..|..            |..:.|::..|...:||.|..:....:.|
Zfish  1489 VICEEGDDDVIEDSFAEGSIDLKC------------KERVTDSDDENEHADEADSKRTFTPVLHS 1541

  Fly   505 SRSCKGKIYQELVNSGQ---LAAIAKKSKARL---------PPAGNMGGNFVDIPLDAGPNTPPV 557
            |.:     :....|..:   ...:|||.|..|         |..|..||....:|..|  |:..|
Zfish  1542 SLT-----FTPTANKHEDRHEENLAKKKKRGLGGAELDNGGPKEGEGGGGGGQVPFHA--NSASV 1599

  Fly   558 SPPERQGSSPDSMQKHIRSVSESSSSGFFDLEEKIKELPALSLDAYLQRKRSTKKKKKFSGTKKQ 622
            :              ||.|                    .|..|||  ..:.|.:......|...
Zfish  1600 T--------------HINS--------------------TLLHDAY--HSQGTVRMAPTIVTNVV 1628

  Fly   623 RNSNSTSGASATSNVAAADAAAKGAVPLSSEQHVRIKQQQLQAVGSQRRKARKESITRRDVSAIE 687
            |...||....|:..|..  ..|.|.:||..:..:.|........|.....:.|.|
Zfish  1629 RPITSTPVPIASKPVDG--GVAVGTLPLDGKPKLLIGTGGAGGGGYFPSSSPKPS---------- 1681

  Fly   688 QEVASILPLTINGSYYFNQ--------------SGAP--KAVNAP-----------VTSSSASPP 725
             ...|::...:.|..:.||              :|||  .||..|           :||.|...|
Zfish  1682 -GQGSLVTGLVLGGTFPNQPTVQLITPPHPTPCNGAPNNNAVPLPLLHHQFLPATSITSPSGGKP 1745

  Fly   726 L------------SSNSSSSSSSLSSQAAFDVTSSTSDLLILAEVAANRTELTKSN 769
            :            ::|.:|.|:..:.|.:          .:||...|..|.:|.:|
Zfish  1746 VTQVQYILPTLPAAANPNSPSTQQTQQPS----------SVLALPGATPTHVTLAN 1791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bbx	NP_001027087.1	SOX-TCF_HMG-box	296..367	CDD:238684	38/70 (54%)
cica	XP_003200581.2	DUF4819	345..451	CDD:292708
		SOX-TCF_HMG-box	1303..1374	CDD:238684	38/70 (54%)
		DUF1421	1673..1958	CDD:284607	26/140 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2746
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900