DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bbx and cic

DIOPT Version :9

Sequence 1:	NP_001027087.1	Gene:	bbx / 3772670	FlyBaseID:	FBgn0024251	Length:	769	Species:	Drosophila melanogaster
Sequence 2:	NP_001262755.1	Gene:	cic / 53560	FlyBaseID:	FBgn0262582	Length:	2150	Species:	Drosophila melanogaster

Alignment Length:	1113	Identity:	203/1113 - (18%)
Similarity:	345/1113 - (30%)	Gaps:	407/1113 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 QQVAQVTPTGAAIK----------LHFAYNNNSNN--SSSSNISNSNYSGLKTSETKMRNNKNYT 63
            ||..|..|....:.          |:.|.||:|||  |||:|.:|||:.....|.|.:......|
  Fly   812 QQQQQQQPVAVPLDSKWKTTPSPVLYNANNNSSNNNTSSSNNNNNSNWEVGSNSNTHVAATAAAT 876

  Fly    64 GRA-----------LKIV-------------------------EKIPGASGVIATTSGNQGARSL 92
            ...           :.:|                         ..:|..|.  ..|||:..:.:.
  Fly   877 STVGAQPLPPQTTPVSLVMHAPPPQQQPLQQQHHHHQPPPPPPASLPAPSA--PPTSGSSSSHNS 939

  Fly    93 EGYSPAAASYVSGLSRDFLISRELSQRSGEFLTAAAKMVSQMG----------ASELR------- 140
            .|::.:.....|        |::..|:..:....|...|...|          |::|.
  Fly   940 VGHATSVIRISS--------SQQQHQQQQQHQQQAHPHVVVSGGQTFHPVIVDATQLSVPLPPTT 996

  Fly   141 ---WLPISRTKDKPSSAGEAEAKTLVREG--------------ESQGSPGKVAKSALGD------ 182
               ..|.:.|....|.|..::.|.|.:.|              .|:.||..|..:....
  Fly   997 VSFHQPNTPTSTAASVASMSQDKMLAKNGYNAPWFKLLPHMTPMSKASPAPVTPTLTTSASSYNV 1061

  Fly   183 ------------PQPQRTEDQENAFRRIEDVHNY------------AKLQDCSSD---------- 213
                        .|.|:.:.|:.:..::...||.            .|..:||.:
  Fly  1062 VMMQQQQQHQQLQQQQQLQQQQQSPPQMPLNHNNNHLIVSAPLSSPGKPLNCSMNDAKVAAAAAA 1126

  Fly   214 ----TDDEDDEEEDLDEEEDDE-------------EEAEIQVQLPVQQEVTRIRREAAEEHVDVD 261
                ...:..::|:.|::.||:             ::....::||......|...|..::.....
  Fly  1127 AAVANQRQKQQQEEPDDQLDDDVFETTTPGISANSKKQTAAMRLPTHNSNIRKLEECHDDGAAGA 1191

  Fly   262 VVTVPQQEQDQYSHQVEPRQLQQDE-----TADNTRPEHHARRPMNAFLIFCKRHRGIVKERYKT 321
            ..|...:.:.|....::.:|.||.:     ||.........|||||||:||.|:||.:|.:::..
  Fly  1192 PATSAAKRRSQSLSALQQQQQQQQQAGAAGTAAGQPANKKIRRPMNAFMIFSKKHRKMVHKKHPN 1256

  Fly   322 LENRAITKILGDWWAALDEQEKHCFTDLAQQNKDAFFNANPNFKWYKLPAPPLRTLATRPSNASA 386
            .:||.::||||:||.||..::|..:.:||...|||.|..:|.:||.........|....|...::
  Fly  1257 QDNRTVSKILGEWWYALKPEQKAQYHELASSVKDAHFKLHPEWKWCSKDRRKSSTSTATPGGKAS 1321

  Fly   387 G--------------------------------------------------LLIPSEDQPQQQVP 401
            |                                                  |.|.:.:....:.|
  Fly  1322 GAAGTGDAKQRLVSVDGSDSLEHDMCPSTPGGSGSCGGQGISSDLQGDIIPLTIDNYNSTCDEAP 1386

  Fly   402 TSLQVQWAERGEMPRAML---RPNYFKLADETQMGELSSLLQVQVQEK-----------DFALQQ 452
            |::.::....|::.:..|   ......:.:|.|..:....:.:..:|:           |:..||
  Fly  1387 TTISMKGNGNGKLMKNELPSDEDEQMLVVEEEQQQQTVKKIDLHCRERVNDSDMDDTPFDYRKQQ 1451

  Fly   453 ------------------------------------------------------VLSETSQFLSA 463
                                                                  .:|..:|:.|.
  Fly  1452 PEANQRSAEEHSTSGANGQAINAPPLSGGEREITLKPKAIKAHPVLESNMLPYTQMSIYTQYTSP 1516

  Fly   464 HMPAGNT----------------NGNGNK----RSLQDNNSSNSSEEEAASGSSPNKKVKSSRSC 508
            ..|.|.|                .|:|.|    .|||.:......::|.   .||.|....|.|.
  Fly  1517 KNPIGVTPFQPTGGAFKSMPISPKGSGGKPEDAGSLQAHIKQEDIKQEP---PSPYKLNNGSGSA 1578

  Fly   509 K--GKIYQELVNSGQLAAI-----------AKKS-------------------KARLP--PAGNM 539
            .  |.:.....|||.:.||           ::|.                   :|.:|  |||..
  Fly  1579 SGGGVVSAPPPNSGSVGAIFNFNVPTATALSQKQFHYPMHHPHRSPTDLRAAHQACVPSSPAGMG 1643

  Fly   540 GGNFVDIPLDAGPNTPPVSPPER-QGSSPDSMQ-----------------------KHIR----- 575
            .|:..:|.      |||.|.|.: .|..|.|.:                       :|::
  Fly  1644 LGHAANIA------TPPASAPAQIMGGGPASQKMFFAMTHPYTLLQRSHQPGTPSLEHLQLDAFA 1702

  Fly   576 --SVSESSSSGFFDLEEKIKELPALSLDAY--------------LQRKRSTKKKKKF--SGTKKQ 622
              ..:..:.:|...|...:...|.:.|..|              .:...||.|...:  |...::
  Fly  1703 PGGYTLRNHNGLSSLPPPVSAQPTMLLHGYPPSHGVEPPARSPSYKSMPSTPKSATYLMSAPPER 1767

  Fly   623 RNSNSTSGASATSNVAAADAAAKGAVPLSSEQHVRI-KQQQLQAVGSQRRKARKESITRRDVS-- 684
            ......||.::    |||....:..:....:|.:.. ...||.....||||...:|.:..:||
  Fly  1768 GMDGGMSGCAS----AAASGGDESDIDADGQQFILAPTPAQLGRAPLQRRKNLSQSKSESNVSFG 1828

  Fly   685 -----AIEQEVASIL--PLTINGSY----YFNQSGAPKAVNAPVTSSSASP------PLSSNSSS 732
                 :..|.::..|  |..:..|.    :.|.|....|:..| |||:.:|      ||:..:||
  Fly  1829 ANLGASNGQHISRKLHSPTMMESSSPIIGHVNSSNLSSALPTP-TSSTTTPNSDEQLPLTPTTSS 1892

  Fly   733 SSSSLSSQ 740
            |:|:|:.|
  Fly  1893 SNSNLNQQ 1900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bbx	NP_001027087.1	SOX-TCF_HMG-box	296..367	CDD:238684	32/70 (46%)
cic	NP_001262755.1	DUF4819	349..431	CDD:292708
cic	NP_001262755.1	SOX-TCF_HMG-box	1231..1302	CDD:238684	32/70 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45435006
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2746
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13059
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.930